Gene description for Ddx17
Gene name DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
Gene symbol Ddx17
Other names/aliases 2610007K22Rik
A430025E01Rik
AI047725
C80929
Gm926
p72
Species Mus musculus
 Database cross references - Ddx17
ExoCarta ExoCarta_67040
Vesiclepedia VP_67040
Entrez Gene 67040
UniProt Q501J6  
 Ddx17 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ddx17
Molecular Function
    ATP-dependent RNA helicase activity GO:0004004 IBA
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 ISO
    helicase activity GO:0004386 IEA
    transcription coactivator activity GO:0003713 ISO
    hydrolase activity GO:0016787 IEA
    nucleic acid binding GO:0003676 IEA
    RNA binding GO:0003723 IEA
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    estrogen receptor binding GO:0030331 ISO
Biological Process
    post-embryonic development GO:0009791 IMP
    cardiovascular system development GO:0072358 IMP
    regulation of skeletal muscle cell differentiation GO:2001014 ISO
    RNA secondary structure unwinding GO:0010501 IBA
    positive regulation of transcription, DNA-templated GO:0045893 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 ISO
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    membrane GO:0016020 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Ddx17 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ddx17
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ddx17 is involved
No pathways found





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