Gene description for Tardbp
Gene name TAR DNA binding protein
Gene symbol Tardbp
Other names/aliases 1190002A23Rik
C85084
TDP-43
Tdp43
Species Mus musculus
 Database cross references - Tardbp
ExoCarta ExoCarta_230908
Vesiclepedia VP_230908
Entrez Gene 230908
UniProt Q921F2  
 Tardbp identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tardbp
Molecular Function
    RNA binding GO:0003723 ISO
    mRNA 3'-UTR binding GO:0003730 ISO
    nucleic acid binding GO:0003676 IEA
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001205 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
    double-stranded DNA binding GO:0003690 ISO
    nucleotide binding GO:0000166 IEA
    identical protein binding GO:0042802 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    negative regulation by host of viral transcription GO:0043922 ISO
    nuclear fragmentation involved in apoptotic nuclear change GO:0030264 ISO
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 ISO
    nuclear inner membrane organization GO:0071765 ISO
    3'-UTR-mediated mRNA stabilization GO:0070935 ISO
    negative regulation of protein phosphorylation GO:0001933 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of gene expression GO:0010629 ISO
    regulation of cell cycle GO:0051726 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
    transcription from RNA polymerase II promoter GO:0006366 IDA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Tardbp in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tardbp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tardbp is involved
No pathways found





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