Gene description for Mtdh
Gene name metadherin
Gene symbol Mtdh
Other names/aliases 2610103J23Rik
3D3
3D3/Lyric
AEG-1
AV353288
D8Bwg1112e
Lyric
Species Mus musculus
 Database cross references - Mtdh
ExoCarta ExoCarta_67154
Vesiclepedia VP_67154
Entrez Gene 67154
UniProt Q80WJ7  
 Mtdh identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Mtdh
Molecular Function
    transcription coregulator activity GO:0003712 IBA
    transcription coactivator activity GO:0003713 IEA
    transcription coactivator activity GO:0003713 ISO
    double-stranded RNA binding GO:0003725 ISO
    protein binding GO:0005515 IPI
    NF-kappaB binding GO:0051059 IBA
    NF-kappaB binding GO:0051059 ISO
    NF-kappaB binding GO:0051059 ISS
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of autophagy GO:0010508 IEA
    positive regulation of autophagy GO:0010508 ISO
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    lipopolysaccharide-mediated signaling pathway GO:0031663 ISO
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    positive regulation of angiogenesis GO:0045766 IEA
    positive regulation of angiogenesis GO:0045766 ISO
    positive regulation of DNA-templated transcription GO:0045893 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
Subcellular Localization
    fibrillar center GO:0001650 IEA
    fibrillar center GO:0001650 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IDA
    bicellular tight junction GO:0005923 IEA
    bicellular tight junction GO:0005923 ISO
    apical plasma membrane GO:0016324 ISO
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
    nuclear membrane GO:0031965 IEA
    intercellular canaliculus GO:0046581 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified Mtdh in sEVs
1
Experiment ID 264
MISEV standards
Biophysical techniques
CD63|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mtdh
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tardbp 230908
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
2 Zbtb7b  
Affinity Capture-MS Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Mtdh is involved
No pathways found





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