Gene description for Mtdh
Gene name metadherin
Gene symbol Mtdh
Other names/aliases 2610103J23Rik
3D3
3D3/Lyric
AEG-1
AV353288
D8Bwg1112e
Lyric
Species Mus musculus
 Database cross references - Mtdh
ExoCarta ExoCarta_67154
Entrez Gene 67154
UniProt Q80WJ7  
 Mtdh identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Mtdh
Molecular Function
    RNA polymerase II transcription factor binding GO:0001085 ISO
    NF-kappaB binding GO:0051059 ISO
    poly(A) RNA binding GO:0044822 ISO
    transcription coactivator activity GO:0003713 ISO
    protein binding GO:0005515 IPI
    double-stranded RNA binding GO:0003725 ISO
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO
    positive regulation of protein kinase B signaling GO:0051897 ISO
    lipopolysaccharide-mediated signaling pathway GO:0031663 ISO
    positive regulation of autophagy GO:0010508 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    cell junction GO:0030054 IEA
    apical plasma membrane GO:0016324 ISO
    nuclear body GO:0016604 ISO
    endoplasmic reticulum GO:0005783 ISO
    integral component of membrane GO:0016021 IEA
    nucleolus GO:0005730 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    endoplasmic reticulum membrane GO:0005789 IDA
    bicellular tight junction GO:0005923 ISO
    intercellular canaliculus GO:0046581 ISO
 Experiment description of studies that identified Mtdh in exosomes
1
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mtdh
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mtdh is involved
No pathways found





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