Gene description for Cdc5l
Gene name cell division cycle 5-like (S. pombe)
Gene symbol Cdc5l
Other names/aliases 1200002I02Rik
AA408004
PCDC5RP
Species Mus musculus
 Database cross references - Cdc5l
ExoCarta ExoCarta_71702
Entrez Gene 71702
UniProt Q6A068  
 Cdc5l identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cdc5l
Molecular Function
    chromatin binding GO:0003682 IEA
    protein domain specific binding GO:0019904 ISO
    RNA binding GO:0003723 IEA
    WD40-repeat domain binding GO:0071987 ISO
    DNA binding GO:0003677 IEA
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    DNA repair GO:0006281 IEA
    signal transduction involved in DNA damage checkpoint GO:0072422 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    mRNA processing GO:0006397 IEA
    cellular response to DNA damage stimulus GO:0006974 IEA
    transcription, DNA-templated GO:0006351 IEA
    cell cycle GO:0007049 IEA
    RNA splicing GO:0008380 IEA
Subcellular Localization
    nucleolus GO:0005730 ISO
    spliceosomal complex GO:0005681 IEA
    DNA replication factor A complex GO:0005662 ISO
    nuclear speck GO:0016607 ISO
    nucleus GO:0005634 ISO
    catalytic step 2 spliceosome GO:0071013 ISO
    nucleoplasm GO:0005654 ISO
    Prp19 complex GO:0000974 ISO
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Cdc5l in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cdc5l
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cdc5l is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway IEA Reactome





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