Gene description for AQR
Gene name aquarius intron-binding spliceosomal factor
Gene symbol AQR
Other names/aliases IBP160
fSAP164
Species Homo sapiens
 Database cross references - AQR
ExoCarta ExoCarta_9716
Vesiclepedia VP_9716
Entrez Gene 9716
HGNC 29513
MIM 610548
UniProt O60306  
 AQR identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for AQR
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 HDA
    single-stranded RNA binding GO:0003727 IDA
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    3'-5' RNA helicase activity GO:0034458 IDA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IC
    mRNA splicing, via spliceosome GO:0000398 IDA
    chromatin remodeling GO:0006338 IEA
    chromatin looping GO:0140588 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    membrane GO:0016020 HDA
    U2-type catalytic step 2 spliceosome GO:0071007 IDA
    catalytic step 2 spliceosome GO:0071013 IBA
    catalytic step 2 spliceosome GO:0071013 IDA
 Experiment description of studies that identified AQR in exosomes
1
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AQR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB2 6629
Affinity Capture-MS Homo sapiens
2 RALY 22913
Affinity Capture-MS Homo sapiens
3 NUPL2 11097
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 RALYL 138046
Affinity Capture-MS Homo sapiens
6 HNRNPC 3183
Affinity Capture-MS Homo sapiens
7 PQBP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 SNRPG 6637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LGR4 55366
Affinity Capture-MS Homo sapiens
10 SNRPE 6635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 Prpf8 192159
Affinity Capture-MS Mus musculus
12 RBM22 55696
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 PPIE 10450
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ACTC1 70
Proximity Label-MS Homo sapiens
15 DHX8 1659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 Ccdc12  
Affinity Capture-MS Mus musculus
17 C9orf78 51759
Affinity Capture-MS Homo sapiens
18 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
19 DVL3 1857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 AAR2 25980
Affinity Capture-MS Homo sapiens
21 CCDC94  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SYF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ILF2 3608
Affinity Capture-MS Homo sapiens
25 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
26 USB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 RNPS1 10921
Affinity Capture-MS Homo sapiens
28 CRNKL1 51340
Co-fractionation Homo sapiens
29 Snw1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
30 ISY1 57461
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 EIF4A3 9775
Affinity Capture-MS Homo sapiens
32 WDR83  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
33 Isy1 57905
Affinity Capture-MS Mus musculus
34 PRC1 9055
Affinity Capture-MS Homo sapiens
35 OBSL1 23363
Affinity Capture-MS Homo sapiens
36 SF3A2 8175
Co-fractionation Homo sapiens
37 SNRPD3 6634
Affinity Capture-MS Homo sapiens
38 CCDC130  
Affinity Capture-MS Homo sapiens
39 MECP2 4204
Affinity Capture-MS Homo sapiens
40 MYCN  
Affinity Capture-MS Homo sapiens
41 PRPF8 10594
Proximity Label-MS Homo sapiens
42 PPIL1 51645
Affinity Capture-MS Homo sapiens
43 RBM4 5936
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 SRSF3 6428
Affinity Capture-MS Homo sapiens
45 Crnkl1  
Affinity Capture-MS Mus musculus
46 BLM 641
Synthetic Growth Defect Homo sapiens
47 PNN 5411
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SRSF6 6431
Affinity Capture-MS Homo sapiens
49 SNRPB 6628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CCDC12  
Affinity Capture-MS Homo sapiens
51 NTRK1 4914
Affinity Capture-MS Homo sapiens
52 NPDC1  
Affinity Capture-MS Homo sapiens
53 KIAA1143  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SNRPN 6638
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 HECTD1 25831
Affinity Capture-MS Homo sapiens
56 MAGOH 4116
Affinity Capture-MS Homo sapiens
57 DDX39B 7919
Affinity Capture-MS Homo sapiens
58 USP28 57646
Affinity Capture-MS Homo sapiens
59 KDF1  
Affinity Capture-MS Homo sapiens
60 PPP4R1 9989
Co-fractionation Homo sapiens
61 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 RBM39 9584
Affinity Capture-MS Homo sapiens
63 UBE2H 7328
Affinity Capture-MS Homo sapiens
64 C11orf57  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 LMNB1 4001
Affinity Capture-MS Homo sapiens
66 SIRT7  
Affinity Capture-MS Homo sapiens
67 CD2BP2 10421
Affinity Capture-MS Homo sapiens
68 PLRG1 5356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
70 XAB2 56949
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
71 DNAJC17  
Affinity Capture-MS Homo sapiens
72 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
73 TSSC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ZC3H11A  
Affinity Capture-MS Homo sapiens
75 SUZ12  
Affinity Capture-MS Homo sapiens
76 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
77 NXF1 10482
Affinity Capture-RNA Homo sapiens
78 SF3A1 10291
Affinity Capture-MS Homo sapiens
79 EFTUD2 9343
Affinity Capture-MS Homo sapiens
80 MAPK6  
Affinity Capture-MS Homo sapiens
81 PRPF19 27339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 RPA3 6119
Proximity Label-MS Homo sapiens
83 ZC3H18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 DNAJC9 23234
Proximity Label-MS Homo sapiens
85 PABPC5 140886
Affinity Capture-MS Homo sapiens
86 METTL21B  
Affinity Capture-MS Homo sapiens
87 SIRT6  
Affinity Capture-MS Homo sapiens
88 RNF2  
Affinity Capture-MS Homo sapiens
89 BMI1  
Affinity Capture-MS Homo sapiens
90 RBBP4 5928
Co-fractionation Homo sapiens
91 ISY1-RAB43 100534599
Co-fractionation Homo sapiens
92 NKAP 79576
Affinity Capture-MS Homo sapiens
93 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
94 EAPP  
Affinity Capture-MS Homo sapiens
95 BCAS2 10286
Affinity Capture-MS Homo sapiens
96 PARP1 142
Proximity Label-MS Homo sapiens
97 WDR77 79084
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
98 CPSF6 11052
Affinity Capture-MS Homo sapiens
99 Cdc5l 71702
Affinity Capture-MS Mus musculus
100 SSRP1 6749
Affinity Capture-MS Homo sapiens
101 MEN1 4221
Affinity Capture-MS Homo sapiens
102 SNRPA 6626
Affinity Capture-MS Homo sapiens
103 CHD4 1108
Affinity Capture-MS Homo sapiens
104 SHMT2 6472
Affinity Capture-RNA Homo sapiens
105 SNRNP40 9410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 SNIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 RTCB 51493
Affinity Capture-MS Homo sapiens
108 SRSF7 6432
Affinity Capture-MS Homo sapiens
109 ZCCHC10  
Affinity Capture-MS Homo sapiens
110 SNW1 22938
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 KRAS 3845
Negative Genetic Homo sapiens
112 CD44 960
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 SNRPA1 6627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 PRMT1 3276
Affinity Capture-MS Homo sapiens
115 ZNF830  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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