Gene description for CD2BP2
Gene name CD2 (cytoplasmic tail) binding protein 2
Gene symbol CD2BP2
Other names/aliases FWP010
LIN1
PPP1R59
Snu40
U5-52K
Species Homo sapiens
 Database cross references - CD2BP2
ExoCarta ExoCarta_10421
Entrez Gene 10421
HGNC 1656
MIM 604470
UniProt O95400  
 CD2BP2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD2BP2
Molecular Function
    ribonucleoprotein complex binding GO:0043021 IDA
    protein binding GO:0005515 IPI
Biological Process
    gene expression GO:0010467 TAS
    spliceosomal tri-snRNP complex assembly GO:0000244 NAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    negative regulation of phosphatase activity GO:0010923 IDA
    RNA splicing GO:0008380 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    nuclear speck GO:0016607 IDA
    U5 snRNP GO:0005682 IDA
    U4/U6 x U5 tri-snRNP complex GO:0046540 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified CD2BP2 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD2BP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF4A2 1974
Affinity Capture-MS Homo sapiens
2 CD2 914
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 CMBL 134147
Affinity Capture-MS Homo sapiens
4 P4HB 5034
Affinity Capture-MS Homo sapiens
5 PRPF6 24148
Affinity Capture-MS Homo sapiens
6 EFTUD2 9343
Affinity Capture-MS Homo sapiens
7 SNRPG 6637
Affinity Capture-MS Homo sapiens
8 SNRNP200 23020
Affinity Capture-MS Homo sapiens
9 DDX23 9416
Affinity Capture-MS Homo sapiens
10 NUDT21 11051
Affinity Capture-MS Homo sapiens
11 SNRPF 6636
Affinity Capture-MS Homo sapiens
12 KHK 3795
Affinity Capture-MS Homo sapiens
13 PRPF8 10594
Affinity Capture-MS Homo sapiens
14 RAD54B  
Affinity Capture-MS Homo sapiens
15 DCD 117159
Affinity Capture-MS Homo sapiens
16 PUF60 22827
Affinity Capture-MS Homo sapiens
17 PRPSAP1 5635
Affinity Capture-MS Homo sapiens
18 USP39 10713
Affinity Capture-MS Homo sapiens
19 SNRNP40 9410
Affinity Capture-MS Homo sapiens
20 EWSR1 2130
Affinity Capture-MS Homo sapiens
21 C5orf41  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CD2BP2 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway TAS Reactome





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