Gene description for ERH
Gene name enhancer of rudimentary homolog (Drosophila)
Gene symbol ERH
Other names/aliases DROER
Species Homo sapiens
 Database cross references - ERH
ExoCarta ExoCarta_2079
Entrez Gene 2079
HGNC 3447
MIM 601191
UniProt P84090  
 ERH identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ERH
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    cell cycle GO:0007049 IEA
    osteoblast differentiation GO:0001649 IEA
    pyrimidine nucleoside metabolic process GO:0006213 TAS
    positive regulation of Notch signaling pathway GO:0045747 IEA
    pyrimidine nucleotide biosynthetic process GO:0006221 IEA
    nucleobase-containing compound metabolic process GO:0006139 TAS
Subcellular Localization
    membrane GO:0016020 IEA
    midbody GO:0030496 IDA
 Experiment description of studies that identified ERH in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ERH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DKFZP564O0523  
Two-hybrid Homo sapiens
2 MED31  
Two-hybrid Homo sapiens
3 ZNF9  
Affinity Capture-MS Homo sapiens
4 TP53  
Two-hybrid Homo sapiens
5 ILK 3611
Affinity Capture-MS Homo sapiens
6 ACP6  
Affinity Capture-MS Homo sapiens
7 MGC15730  
Two-hybrid Homo sapiens
8 GC20  
Affinity Capture-MS Homo sapiens
9 BIN3  
Affinity Capture-MS Homo sapiens
10 UNC119  
Two-hybrid Homo sapiens
11 SH3GL2  
Two-hybrid Homo sapiens
12 TLE1  
Two-hybrid Homo sapiens
13 HSPA8 3312
Two-hybrid Homo sapiens
14 COPS6 10980
Two-hybrid Homo sapiens
15 SETDB1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ERH is involved
No pathways found

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