Gene description for TLE1
Gene name transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Gene symbol TLE1
Other names/aliases ESG
ESG1
GRG1
Species Homo sapiens
 Database cross references - TLE1
ExoCarta ExoCarta_7088
Vesiclepedia VP_7088
Entrez Gene 7088
HGNC 11837
MIM 600189
UniProt Q04724  
 TLE1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TLE1
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    DNA-binding transcription factor binding GO:0140297 IPI
Biological Process
    signal transduction GO:0007165 TAS
    animal organ morphogenesis GO:0009887 TAS
    positive regulation of gene expression GO:0010628 IMP
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of Wnt signaling pathway GO:0030178 IDA
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    negative regulation of anoikis GO:2000811 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IMP
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IBA
    cytosol GO:0005829 IMP
    beta-catenin-TCF complex GO:1990907 IDA
 Experiment description of studies that identified TLE1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TLE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Proximity Label-MS Homo sapiens
2 ZFP64  
Two-hybrid Homo sapiens
3 ISX  
Proximity Label-MS Homo sapiens
4 SNRPG 6637
Two-hybrid Homo sapiens
5 IRF4  
Proximity Label-MS Homo sapiens
6 TK1 7083
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 NFIB  
Proximity Label-MS Homo sapiens
8 AES 166
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
9 GADD45A  
Two-hybrid Homo sapiens
10 RPA2 6118
Two-hybrid Homo sapiens
11 Hes1  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
12 GATA2  
Proximity Label-MS Homo sapiens
13 EN1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PLSCR4  
Affinity Capture-MS Homo sapiens
15 SIX6  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
16 PAX2  
Proximity Label-MS Homo sapiens
17 MFAP4 4239
Affinity Capture-MS Homo sapiens
18 TLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 KDM6A  
Two-hybrid Homo sapiens
20 TBX1  
Affinity Capture-MS Homo sapiens
21 ATN1  
Two-hybrid Homo sapiens
22 SOX10  
Proximity Label-MS Homo sapiens
23 SOX2  
Proximity Label-MS Homo sapiens
24 PCBP3 54039
Affinity Capture-MS Homo sapiens
25 MYOD1  
Proximity Label-MS Homo sapiens
26 CDKN1A  
Two-hybrid Homo sapiens
27 GRB7 2886
Two-hybrid Homo sapiens
28 IL6ST 3572
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
29 PARK2  
Affinity Capture-MS Homo sapiens
30 Foxg1  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
31 FBXL14  
Affinity Capture-MS Homo sapiens
32 ARL3 403
Two-hybrid Homo sapiens
33 FOXA3  
Two-hybrid Homo sapiens
34 ESRRG  
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
35 HES6  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
36 HEY1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
37 NUP35 129401
Proximity Label-MS Homo sapiens
38 NPM1 4869
Co-fractionation Homo sapiens
39 ETV4  
Proximity Label-MS Homo sapiens
40 GCM1  
Proximity Label-MS Homo sapiens
41 LEF1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
42 ARMC8 25852
Affinity Capture-MS Homo sapiens
43 SRP14 6727
Affinity Capture-MS Homo sapiens
44 TEAD1  
Proximity Label-MS Homo sapiens
45 RCC1 1104
Two-hybrid Homo sapiens
46 FEV  
Proximity Label-MS Homo sapiens
47 LHX4  
Proximity Label-MS Homo sapiens
48 MPHOSPH6 10200
Two-hybrid Homo sapiens
49 CSNK2B 1460
Two-hybrid Homo sapiens
50 STARD7 56910
Affinity Capture-MS Homo sapiens
51 GFI1B  
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
52 GSK3B 2932
Two-hybrid Homo sapiens
53 SERPINB9 5272
Two-hybrid Homo sapiens
54 RUNX1  
Two-hybrid Homo sapiens
Far Western Homo sapiens
55 PFN1 5216
Two-hybrid Homo sapiens
56 ATF2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 ANXA7 310
Two-hybrid Homo sapiens
58 FOXA1  
Two-hybrid Homo sapiens
59 PRDM1  
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
60 CELF3  
Two-hybrid Homo sapiens
61 TLX3  
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
62 CUL4B 8450
Affinity Capture-MS Homo sapiens
63 QPRT 23475
Affinity Capture-MS Homo sapiens
64 MSX2  
Two-hybrid Homo sapiens
65 TBR1  
Proximity Label-MS Homo sapiens
66 NOD2 64127
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
67 PSMD11 5717
Two-hybrid Homo sapiens
68 NFIX 4784
Proximity Label-MS Homo sapiens
69 SSX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 DAZAP2  
Two-hybrid Homo sapiens
71 LHX1  
Proximity Label-MS Homo sapiens
72 RAP1B 5908
Two-hybrid Homo sapiens
73 NFIA 4774
Proximity Label-MS Homo sapiens
74 RIPPLY2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 FUBP1 8880
Two-hybrid Homo sapiens
76 GATA3  
Proximity Label-MS Homo sapiens
77 NCL 4691
Co-fractionation Homo sapiens
78 LHX3  
Proximity Label-MS Homo sapiens
79 LHX8  
Proximity Label-MS Homo sapiens
80 PARP1 142
Co-fractionation Homo sapiens
81 PCDHA4 56144
Two-hybrid Homo sapiens
82 PAX8  
Proximity Label-MS Homo sapiens
83 UBTF 7343
Affinity Capture-Western Homo sapiens
84 BCL2L1 598
Two-hybrid Homo sapiens
85 MYH10 4628
Co-fractionation Homo sapiens
86 UTY  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
87 T  
Proximity Label-MS Homo sapiens
88 POLB 5423
Two-hybrid Homo sapiens
89 VENTX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
90 SAT1  
Two-hybrid Homo sapiens
91 Morf4l1 21761
Affinity Capture-Western Mus musculus
92 SOX17  
Proximity Label-MS Homo sapiens
93 KLF4  
Proximity Label-MS Homo sapiens
94 FOXA2  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
95 SIX2  
Affinity Capture-MS Homo sapiens
96 VSX1  
Proximity Label-MS Homo sapiens
97 DLEU1  
Two-hybrid Homo sapiens
98 TLX2  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
99 PAX6  
Proximity Label-MS Homo sapiens
100 NKX2-5  
Two-hybrid Homo sapiens
101 POLE2  
Two-hybrid Homo sapiens
102 TLE2  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 SOX6  
Proximity Label-MS Homo sapiens
104 BARHL1  
Two-hybrid Homo sapiens
105 RELA 5970
Affinity Capture-Western Homo sapiens
106 ELK3  
Proximity Label-MS Homo sapiens
107 CTNNB1 1499
Reconstituted Complex Homo sapiens
108 TBX20 57057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 FOXI1  
Proximity Label-MS Homo sapiens
110 FOXG1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
111 FXYD6  
Two-hybrid Homo sapiens
112 FOXL1  
Proximity Label-MS Homo sapiens
113 HOXA1 3198
Affinity Capture-MS Homo sapiens
114 EIF2S2 8894
Two-hybrid Homo sapiens
115 SS18  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
116 SOX15  
Proximity Label-MS Homo sapiens
117 HNF4A  
Proximity Label-MS Homo sapiens
118 HES4  
Affinity Capture-MS Homo sapiens
119 SIX3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
120 HLA-DQA1 3117
Two-hybrid Homo sapiens
121 FOS 2353
Proximity Label-MS Homo sapiens
122 Tmsb4x  
Two-hybrid Mus musculus
123 ARL4D  
Two-hybrid Homo sapiens
124 RUNX2  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
125 HSPA1A 3303
Affinity Capture-MS Homo sapiens
126 HSPA4 3308
Co-fractionation Homo sapiens
127 SOX5 6660
Proximity Label-MS Homo sapiens
128 PEX2  
Two-hybrid Homo sapiens
129 FOXQ1  
Proximity Label-MS Homo sapiens
130 EN2  
Affinity Capture-MS Homo sapiens
131 HLX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 SOX9  
Proximity Label-MS Homo sapiens
133 NFIC 4782
Proximity Label-MS Homo sapiens
134 RIPPLY3  
Affinity Capture-MS Homo sapiens
135 CDKN2C  
Two-hybrid Homo sapiens
136 HESX1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
137 SATB1 6304
Affinity Capture-MS Homo sapiens
138 FGL1  
Affinity Capture-MS Homo sapiens
139 TLX1  
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
140 HSPE1 3336
Two-hybrid Homo sapiens
141 NUDT21 11051
Two-hybrid Homo sapiens
142 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
143 FASN 2194
Positive Genetic Homo sapiens
144 SMN1 6606
Two-hybrid Homo sapiens
145 HHEX  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
146 PROP1  
Affinity Capture-Western Homo sapiens
147 ELF5  
Proximity Label-MS Homo sapiens
148 PAFAH1B3 5050
Two-hybrid Homo sapiens
149 HMGB1 3146
Reconstituted Complex Homo sapiens
150 ERH 2079
Two-hybrid Homo sapiens
151 GSTM4 2948
Two-hybrid Homo sapiens
152 FOXB1  
Affinity Capture-MS Homo sapiens
153 CCL18  
Two-hybrid Homo sapiens
154 TNNI2 7136
Affinity Capture-MS Homo sapiens
155 TLE1 7088
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
156 RUNX3  
Two-hybrid Homo sapiens
Far Western Homo sapiens
157 BID  
Two-hybrid Homo sapiens
158 HDAC1 3065
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
159 PAX9  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
160 SIRT1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
161 CDK1 983
Biochemical Activity Homo sapiens
162 TLE4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 ESR1  
Affinity Capture-MS Homo sapiens
164 KLF5  
Proximity Label-MS Homo sapiens
165 BTBD2  
Two-hybrid Homo sapiens
166 PAX7  
Proximity Label-MS Homo sapiens
167 TCF4  
Reconstituted Complex Homo sapiens
168 TSC22D1 8848
Two-hybrid Homo sapiens
169 EZH2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
170 RIPPLY1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 RNF10  
Two-hybrid Homo sapiens
172 IFT43  
Affinity Capture-MS Homo sapiens
173 TCF3  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
174 HES1 3280
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
175 ERG  
Proximity Label-MS Homo sapiens
176 HNF1B  
Proximity Label-MS Homo sapiens
177 SOX7  
Proximity Label-MS Homo sapiens
178 APH1A 51107
Two-hybrid Homo sapiens
179 AR 367
Proximity Label-MS Homo sapiens
180 LHX2  
Proximity Label-MS Homo sapiens
181 SP7  
Proximity Label-MS Homo sapiens
182 KIAA0408  
Two-hybrid Homo sapiens
183 KLF3  
Proximity Label-MS Homo sapiens
184 CRCT1  
Two-hybrid Homo sapiens
185 MAEA 10296
Affinity Capture-MS Homo sapiens
186 IRF8  
Proximity Label-MS Homo sapiens
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