Gene description for TBX20
Gene name T-box 20
Gene symbol TBX20
Other names/aliases ASD4
Species Homo sapiens
 Database cross references - TBX20
ExoCarta ExoCarta_57057
Vesiclepedia VP_57057
Entrez Gene 57057
HGNC 11598
MIM 606061
UniProt Q9UMR3  
 TBX20 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TBX20
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    RNA polymerase II activating transcription factor binding GO:0001102 ISS
    RNA polymerase II transcription factor binding GO:0001085 ISS
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II transcription coactivator activity GO:0001105 IDA
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    foramen ovale closure GO:0035922 IMP
    endocardial cushion formation GO:0003272 ISS
    transcription, DNA-templated GO:0006351 IEA
    embryonic heart tube elongation GO:0036306 IEA
    cell proliferation GO:0008283 IEA
    cardiac muscle tissue morphogenesis GO:0055008 ISS
    pulmonary vein morphogenesis GO:0060577 IMP
    positive regulation of cardiac muscle cell proliferation GO:0060045 ISS
    embryonic heart tube morphogenesis GO:0003143 ISS
    visceral motor neuron differentiation GO:0021524 ISS
    aortic valve morphogenesis GO:0003180 IMP
    pulmonary valve formation GO:0003193 ISS
    pericardium morphogenesis GO:0003344 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    patterning of blood vessels GO:0001569 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    neuron migration GO:0001764 IEA
    tricuspid valve development GO:0003175 ISS
    heart looping GO:0001947 ISS
    endoderm formation GO:0001706 ISS
    muscle contraction GO:0006936 IEA
    dorsal/ventral pattern formation GO:0009953 ISS
    blood circulation GO:0008015 IEA
    negative regulation of SMAD protein complex assembly GO:0010991 IEA
    cardiac chamber formation GO:0003207 ISS
    outflow tract septum morphogenesis GO:0003148 IMP
    cardiac right ventricle morphogenesis GO:0003215 ISS
    endocardial cushion morphogenesis GO:0003203 ISS
    lateral mesoderm formation GO:0048370 ISS
    cardiac septum development GO:0003279 ISS
    atrial septum morphogenesis GO:0060413 IMP
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified TBX20 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TBX20
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TBX20 is involved
No pathways found





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