Gene description for CTPS2
Gene name CTP synthase 2
Gene symbol CTPS2
Other names/aliases -
Species Homo sapiens
 Database cross references - CTPS2
ExoCarta ExoCarta_56474
Entrez Gene 56474
HGNC 2520
MIM 300380
UniProt Q9NRF8  
 CTPS2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for CTPS2
Molecular Function
    CTP synthase activity GO:0003883 EXP
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
Biological Process
    glutamine metabolic process GO:0006541 IEA
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    nucleobase-containing small molecule interconversion GO:0015949 TAS
    small molecule metabolic process GO:0044281 TAS
    'de novo' CTP biosynthetic process GO:0044210 IEA
    pyrimidine nucleotide metabolic process GO:0006220 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified CTPS2 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTPS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPG21 51324
Two-hybrid Homo sapiens
2 CTPS2 56474
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CTPS2 is involved
PathwayEvidenceSource
Synthesis and interconversion of nucleotide di- and triphosphates TAS Reactome





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