Gene description for OTUD5
Gene name OTU deubiquitinase 5
Gene symbol OTUD5
Other names/aliases DUBA
Species Homo sapiens
 Database cross references - OTUD5
ExoCarta ExoCarta_55593
Entrez Gene 55593
HGNC 25402
MIM 300713
UniProt Q96G74  
 OTUD5 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for OTUD5
Molecular Function
    ubiquitin-specific protease activity GO:0004843 IDA
Biological Process
    protein K63-linked deubiquitination GO:0070536 IDA
    response to lipopolysaccharide GO:0032496 IDA
    negative regulation of type I interferon production GO:0032480 TAS
    innate immune response GO:0045087 TAS
    protein K48-linked deubiquitination GO:0071108 IDA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified OTUD5 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for OTUD5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which OTUD5 is involved
PathwayEvidenceSource
Negative regulators of RIG-I/MDA5 signaling TAS Reactome





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