Gene description for GRN
Gene name granulin
Gene symbol GRN
Other names/aliases CLN11
GEP
GP88
PCDGF
PEPI
PGRN
Species Homo sapiens
 Database cross references - GRN
ExoCarta ExoCarta_2896
Entrez Gene 2896
HGNC 4601
MIM 138945
UniProt P28799  
 GRN identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
 Gene ontology annotations for GRN
Molecular Function
    growth factor activity GO:0008083 TAS
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    cytokine activity GO:0005125 IEA
Biological Process
    signal transduction GO:0007165 NAS
    embryo implantation GO:0007566 IEA
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    blastocyst hatching GO:0001835 IEA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IEA
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified GRN in exosomes
1
Experiment ID 136
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|HSP90|RAB5
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name PC3 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
2
Experiment ID 137
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|HSP90|RAB6
EV Cytosolic markers
✔
CD10
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name PC3 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for GRN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLPI 6590
Affinity Capture-Western Homo sapiens
2 HK3  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 FLJ36766  
Two-hybrid Homo sapiens
4 TAT  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 TOP3B  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 SMAD9  
Affinity Capture-MS Homo sapiens
7 DLK1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
8 CDK9 1025
Affinity Capture-Western Homo sapiens
9 HOXA1  
Two-hybrid Homo sapiens
10 CCNT1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which GRN is involved
No pathways found





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