Gene description for INTS9
Gene name integrator complex subunit 9
Gene symbol INTS9
Other names/aliases CPSF2L
INT9
RC74
Species Homo sapiens
 Database cross references - INTS9
ExoCarta ExoCarta_55756
Vesiclepedia VP_55756
Entrez Gene 55756
HGNC 25592
MIM 611352
UniProt Q9NV88  
 INTS9 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for INTS9
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    snRNA processing GO:0016180 IDA
    snRNA processing GO:0016180 NAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IMP
    regulation of transcription elongation by RNA polymerase II GO:0034243 NAS
    snRNA 3'-end processing GO:0034472 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    integrator complex GO:0032039 IBA
    integrator complex GO:0032039 IDA
    integrator complex GO:0032039 NAS
 Experiment description of studies that identified INTS9 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for INTS9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2B 5431
Affinity Capture-MS Homo sapiens
2 INTS4  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
3 CALML3 810
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
7 POLR2F  
Affinity Capture-MS Homo sapiens
8 KPNA1 3836
Affinity Capture-MS Homo sapiens
9 TBC1D2 55357
Co-fractionation Homo sapiens
10 POLR2J  
Affinity Capture-MS Homo sapiens
11 POLR2H 5437
Affinity Capture-MS Homo sapiens
12 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
13 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 POLR2K  
Affinity Capture-MS Homo sapiens
15 POLR2E 5434
Affinity Capture-MS Homo sapiens
16 MEN1 4221
Affinity Capture-MS Homo sapiens
17 INTS10  
Affinity Capture-MS Homo sapiens
18 VWA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 C7orf76  
Affinity Capture-MS Homo sapiens
20 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
21 NABP2  
Affinity Capture-MS Homo sapiens
22 SHFM1 7979
Affinity Capture-MS Homo sapiens
23 KPNA2 3838
Affinity Capture-MS Homo sapiens
24 WDR73  
Affinity Capture-MS Homo sapiens
25 INTS1 26173
Affinity Capture-MS Homo sapiens
26 ACADVL 37
Co-fractionation Homo sapiens
27 SUPT5H 6829
Affinity Capture-MS Homo sapiens
28 TRIP10 9322
Co-fractionation Homo sapiens
29 SPANXN4  
Affinity Capture-MS Homo sapiens
30 BRAT1 221927
Affinity Capture-MS Homo sapiens
31 GRN 2896
Affinity Capture-MS Homo sapiens
32 TOP1 7150
Affinity Capture-MS Homo sapiens
33 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 RPA3 6119
Proximity Label-MS Homo sapiens
35 TXNIP 10628
Two-hybrid Homo sapiens
36 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
37 CIT 11113
Affinity Capture-MS Homo sapiens
38 POLR2I 5438
Affinity Capture-MS Homo sapiens
39 AP1B1 162
Co-fractionation Homo sapiens
40 Ints4  
Affinity Capture-MS Mus musculus
41 INTS3 65123
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 KRAS 3845
Negative Genetic Homo sapiens
43 NDUFA3  
Affinity Capture-MS Homo sapiens
44 SSRP1 6749
Affinity Capture-MS Homo sapiens
45 NELFB 25920
Affinity Capture-MS Homo sapiens
46 CPSF3L 54973
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 INTS5 80789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
48 GAPDH 2597
Affinity Capture-MS Homo sapiens
49 PPP2CB 5516
Affinity Capture-MS Homo sapiens
50 BRD4 23476
Affinity Capture-MS Homo sapiens
51 INTS6 26512
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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