Gene description for POLR2I
Gene name polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
Gene symbol POLR2I
Other names/aliases RPB9
hRPB14.5
Species Homo sapiens
 Database cross references - POLR2I
ExoCarta ExoCarta_5438
Vesiclepedia VP_5438
Entrez Gene 5438
HGNC 9196
MIM 180662
UniProt P36954  
 POLR2I identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for POLR2I
Molecular Function
    nucleic acid binding GO:0003676 IEA
    DNA-directed 5'-3' RNA polymerase activity GO:0003899 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II GO:0001193 IBA
    transcription-coupled nucleotide-excision repair GO:0006283 IBA
    transcription by RNA polymerase II GO:0006366 IDA
    transcription initiation at RNA polymerase II promoter GO:0006367 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    RNA polymerase II, core complex GO:0005665 IBA
    RNA polymerase II, core complex GO:0005665 IDA
    nucleolus GO:0005730 IEA
 Experiment description of studies that identified POLR2I in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for POLR2I
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 POLR2G 5436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 RNGTT 8732
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CD3EAP  
Affinity Capture-MS Homo sapiens
6 MED17  
Affinity Capture-MS Homo sapiens
7 MED20 9477
Affinity Capture-MS Homo sapiens
8 WWP1 11059
Affinity Capture-MS Homo sapiens
9 MED6  
Affinity Capture-MS Homo sapiens
10 Gtf2b  
Affinity Capture-MS Mus musculus
11 MED29  
Affinity Capture-MS Homo sapiens
12 BRCA1 672
Affinity Capture-MS Homo sapiens
13 MED13L 23389
Affinity Capture-MS Homo sapiens
14 FAM168A  
Affinity Capture-MS Homo sapiens
15 VHL  
Affinity Capture-MS Homo sapiens
16 SCAF4 57466
Affinity Capture-MS Homo sapiens
17 SNRPF 6636
Affinity Capture-MS Homo sapiens
18 CDK8 1024
Affinity Capture-MS Homo sapiens
19 URI1  
Affinity Capture-MS Homo sapiens
20 INTS9 55756
Affinity Capture-MS Homo sapiens
21 TCEB3 6924
Co-localization Homo sapiens
Co-localization Homo sapiens
22 LMO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MED13 9969
Affinity Capture-MS Homo sapiens
24 WDR48 57599
Affinity Capture-MS Homo sapiens
25 COPS5 10987
Co-fractionation Homo sapiens
26 SRC 6714
Co-localization Homo sapiens
Co-localization Homo sapiens
27 MED27  
Affinity Capture-MS Homo sapiens
28 CRCP  
Affinity Capture-MS Homo sapiens
29 MED22  
Affinity Capture-MS Homo sapiens
30 PSMB9 5698
Co-localization Homo sapiens
Co-localization Homo sapiens
31 POLR2C 5432
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
32 GPN1  
Affinity Capture-MS Homo sapiens
33 POLR1E  
Affinity Capture-MS Homo sapiens
34 POLR2M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 MYCN  
Affinity Capture-MS Homo sapiens
36 CCNC  
Affinity Capture-MS Homo sapiens
37 MSL3  
Affinity Capture-MS Homo sapiens
38 MED4 29079
Affinity Capture-MS Homo sapiens
39 GPN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 POLR2K  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
41 MED1 5469
Affinity Capture-MS Homo sapiens
42 INTS12  
Affinity Capture-MS Homo sapiens
43 CDKN2AIP  
Affinity Capture-MS Homo sapiens
44 CPNE2 221184
Affinity Capture-MS Homo sapiens
45 SCAF1  
Affinity Capture-MS Homo sapiens
46 MED7  
Affinity Capture-MS Homo sapiens
47 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
48 UXT 8409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CTDP1 9150
Affinity Capture-MS Homo sapiens
50 POLR3K  
Affinity Capture-MS Homo sapiens
51 ATP6V1G2  
Affinity Capture-MS Homo sapiens
52 SUPT5H 6829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 PFDN2 5202
Affinity Capture-MS Homo sapiens
54 MED26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 FBLN5 10516
Affinity Capture-MS Homo sapiens
56 MED31  
Affinity Capture-MS Homo sapiens
57 MED9  
Affinity Capture-MS Homo sapiens
58 POLR2B 5431
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 RECQL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 POLR3A 11128
Affinity Capture-MS Homo sapiens
61 POLR2H 5437
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 XPO1 7514
Affinity Capture-MS Homo sapiens
63 LMNB1 4001
Affinity Capture-MS Homo sapiens
64 EPAS1  
Affinity Capture-MS Homo sapiens
65 POLR2E 5434
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
66 ASB6 140459
Affinity Capture-MS Homo sapiens
67 RPRD2  
Affinity Capture-MS Homo sapiens
68 CDK19 23097
Affinity Capture-MS Homo sapiens
69 CUL3 8452
Affinity Capture-MS Homo sapiens
70 PCIF1 63935
Affinity Capture-MS Homo sapiens
71 RPRD1A  
Affinity Capture-MS Homo sapiens
72 POLR2D  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 POLR2A 5430
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 TBCD 6904
Two-hybrid Homo sapiens
75 SYDE1 85360
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
77 MED10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
79 MYC  
Dosage Lethality Homo sapiens
Affinity Capture-MS Homo sapiens
80 INTS3 65123
Affinity Capture-MS Homo sapiens
81 POLR1A  
Affinity Capture-MS Homo sapiens
82 RPAP3 79657
Affinity Capture-MS Homo sapiens
83 SIRT6  
Affinity Capture-MS Homo sapiens
84 NELFB 25920
Affinity Capture-MS Homo sapiens
85 CPSF3L 54973
Affinity Capture-MS Homo sapiens
86 MED14  
Affinity Capture-MS Homo sapiens
87 MED11  
Affinity Capture-MS Homo sapiens
88 POLR3E 55718
Affinity Capture-MS Homo sapiens
89 MED19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 CPSF6 11052
Co-fractionation Homo sapiens
91 POLR2F  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 RBM45  
Affinity Capture-MS Homo sapiens
93 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 POLR1B 84172
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
95 POLR2L 5441
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 PHRF1  
Affinity Capture-MS Homo sapiens
97 WDR92 116143
Affinity Capture-MS Homo sapiens
98 POLR3H  
Affinity Capture-MS Homo sapiens
99 CUL5 8065
Affinity Capture-MS Homo sapiens
100 SNRPA 6626
Affinity Capture-MS Homo sapiens
101 MED8  
Affinity Capture-MS Homo sapiens
102 RPAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 INTS8  
Affinity Capture-MS Homo sapiens
104 NELFA  
Affinity Capture-MS Homo sapiens
105 GTF2B 2959
Affinity Capture-MS Homo sapiens
106 ESR1  
Co-localization Homo sapiens
Co-localization Homo sapiens
107 MED30  
Affinity Capture-MS Homo sapiens
108 WWP2 11060
Affinity Capture-MS Homo sapiens
109 MED18  
Affinity Capture-MS Homo sapiens
110 MED21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 MED12  
Affinity Capture-MS Homo sapiens
112 Rprd1b  
Affinity Capture-MS Mus musculus
113 POLR1C 9533
Affinity Capture-MS Homo sapiens
114 POLR3D  
Affinity Capture-MS Homo sapiens
115 POLR3B 55703
Affinity Capture-MS Homo sapiens
116 RPRD1B 58490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 PIH1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 ZNRD1  
Affinity Capture-MS Homo sapiens
119 KRAS 3845
Negative Genetic Homo sapiens
120 POLR1D 51082
Affinity Capture-MS Homo sapiens
121 CCT8L2  
Affinity Capture-MS Homo sapiens
122 PDRG1  
Affinity Capture-MS Homo sapiens
123 MED28  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which POLR2I is involved
PathwayEvidenceSource
Abortive elongation of HIV-1 transcript in the absence of Tat IEA Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Cell Cycle TAS Reactome
Chromosome Maintenance TAS Reactome
Developmental Biology IEA Reactome
Disease IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers IEA Reactome
DNA Repair TAS Reactome
Dual incision in TC-NER TAS Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
FGFR2 alternative splicing TAS Reactome
FGFR2 mutant receptor activation IEA Reactome
Formation of HIV elongation complex in the absence of HIV Tat IEA Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat TAS Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat IEA Reactome
Formation of RNA Pol II elongation complex TAS Reactome
Formation of TC-NER Pre-Incision Complex TAS Reactome
Formation of the Early Elongation Complex TAS Reactome
Formation of the HIV-1 Early Elongation Complex IEA Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene Silencing by RNA IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
HIV elongation arrest and recovery IEA Reactome
HIV Infection IEA Reactome
HIV Infection TAS Reactome
HIV Life Cycle IEA Reactome
HIV Life Cycle TAS Reactome
HIV Transcription Elongation TAS Reactome
HIV Transcription Elongation IEA Reactome
HIV Transcription Initiation IEA Reactome
Infectious disease IEA Reactome
Infectious disease TAS Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
Late Phase of HIV Life Cycle IEA Reactome
Late Phase of HIV Life Cycle TAS Reactome
Metabolism of RNA TAS Reactome
MicroRNA (miRNA) biogenesis TAS Reactome
mRNA Capping TAS Reactome
mRNA Splicing TAS Reactome
mRNA Splicing - Major Pathway TAS Reactome
mRNA Splicing - Minor Pathway TAS Reactome
Nucleotide Excision Repair TAS Reactome
Pausing and recovery of HIV elongation IEA Reactome
Pausing and recovery of Tat-mediated HIV elongation IEA Reactome
PIWI-interacting RNA (piRNA) biogenesis IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection IEA Reactome
RNA Polymerase II HIV Promoter Escape IEA Reactome
RNA Polymerase II Pre-transcription Events TAS Reactome
RNA Polymerase II Promoter Escape TAS Reactome
RNA polymerase II transcribes snRNA genes TAS Reactome
RNA polymerase II transcribes snRNA genes IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RNA Polymerase II Transcription Elongation TAS Reactome
RNA Polymerase II Transcription Initiation TAS Reactome
RNA Polymerase II Transcription Initiation And Promoter Clearance TAS Reactome
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TAS Reactome
Signal Transduction TAS Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease IEA Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR2 IIIa TM IEA Reactome
Signaling by FGFR2 in disease IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Tat-mediated elongation of the HIV-1 transcript TAS Reactome
Tat-mediated elongation of the HIV-1 transcript IEA Reactome
Tat-mediated HIV elongation arrest and recovery IEA Reactome
Telomere Maintenance TAS Reactome
TP53 Regulates Transcription of DNA Repair Genes TAS Reactome
Transcription of the HIV genome IEA Reactome
Transcription of the HIV genome TAS Reactome
Transcription-Coupled Nucleotide Excision Repair (TC-NER) TAS Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Viral Infection Pathways IEA Reactome
Viral Infection Pathways TAS Reactome
Viral Messenger RNA Synthesis TAS Reactome





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