Gene description for UXT
Gene name ubiquitously-expressed, prefoldin-like chaperone
Gene symbol UXT
Other names/aliases ART-27
STAP1
Species Homo sapiens
 Database cross references - UXT
ExoCarta ExoCarta_8409
Vesiclepedia VP_8409
Entrez Gene 8409
HGNC 12641
MIM 300234
UniProt Q9UBK9  
 UXT identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UXT
Molecular Function
    chromatin binding GO:0003682 IDA
    RNA polymerase II transcription corepressor activity GO:0001106 IDA
    beta-tubulin binding GO:0048487 IDA
    actin filament binding GO:0051015 IDA
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 TAS
Biological Process
    microtubule cytoskeleton organization GO:0000226 IMP
    centrosome organization GO:0051297 IMP
    mitochondrion transport along microtubule GO:0047497 TAS
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
Subcellular Localization
    centrosome GO:0005813 IDA
    nucleus GO:0005634 IDA
    cytoskeleton GO:0005856 IDA
    cytoplasm GO:0005737 IDA
    gamma-tubulin complex GO:0000930 IDA
 Experiment description of studies that identified UXT in exosomes
1
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UXT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GLE1 2733
Two-hybrid Homo sapiens
2 LRPPRC 10128
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 AR 367
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 SKP2  
Affinity Capture-MS Homo sapiens
5 LSM1 27257
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 CITED2  
Two-hybrid Homo sapiens
7 CECR2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
8 BUB3 9184
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which UXT is involved
No pathways found





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