Gene description for SUPT6H
Gene name suppressor of Ty 6 homolog (S. cerevisiae)
Gene symbol SUPT6H
Other names/aliases SPT6
SPT6H
emb-5
Species Homo sapiens
 Database cross references - SUPT6H
ExoCarta ExoCarta_6830
Vesiclepedia VP_6830
Entrez Gene 6830
HGNC 11470
MIM 601333
UniProt Q7KZ85  
 SUPT6H identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for SUPT6H
Molecular Function
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    nucleosome binding GO:0031491 IBA
    histone binding GO:0042393 IBA
    histone binding GO:0042393 IDA
Biological Process
    blastocyst formation GO:0001825 IEA
    transcription elongation by RNA polymerase II GO:0006368 IBA
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
    regulation of mRNA export from nucleus GO:0010793 ISS
    positive regulation of transcription elongation by RNA polymerase II GO:0032968 IMP
    nucleosome organization GO:0034728 IBA
    regulation of isotype switching GO:0045191 ISS
    regulation of mRNA processing GO:0050684 ISS
    mRNA transport GO:0051028 IEA
    regulation of muscle cell differentiation GO:0051147 ISS
    transcription elongation-coupled chromatin remodeling GO:0140673 IMP
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    transcription elongation factor complex GO:0008023 IBA
 Experiment description of studies that identified SUPT6H in exosomes
1
Experiment ID 363
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
Biophysical techniques
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
DCLK1
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SUPT6H
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2B 5431
Affinity Capture-MS Homo sapiens
2 SNRPA 6626
Affinity Capture-MS Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 GMNN  
Affinity Capture-MS Homo sapiens
6 Hax1  
Affinity Capture-MS Mus musculus
7 MED17  
Affinity Capture-MS Homo sapiens
8 COIL  
Proximity Label-MS Homo sapiens
9 HSPA6 3310
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
10 TCEB3 6924
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
11 SRPK2 6733
Affinity Capture-MS Homo sapiens
12 RPA2 6118
Proximity Label-MS Homo sapiens
13 BRCA1 672
Affinity Capture-MS Homo sapiens
14 KIF20A 10112
Affinity Capture-MS Homo sapiens
15 CSNK2A1 1457
Biochemical Activity Homo sapiens
16 RIOK3 8780
Affinity Capture-MS Homo sapiens
17 SCAF4 57466
Affinity Capture-MS Homo sapiens
18 SNRPF 6636
Affinity Capture-MS Homo sapiens
19 POLR2H 5437
Affinity Capture-MS Homo sapiens
20 RNF40 9810
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 DEGS1  
Affinity Capture-MS Homo sapiens
22 TCEA1 6917
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
23 TMA16  
Affinity Capture-MS Homo sapiens
24 FBXW4 6468
Affinity Capture-MS Homo sapiens
25 PAAF1 80227
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 PARK2  
Affinity Capture-MS Homo sapiens
27 RUVBL1 8607
Affinity Capture-MS Homo sapiens
28 WDR48 57599
Affinity Capture-MS Homo sapiens
29 RNPS1 10921
Affinity Capture-MS Homo sapiens
30 TBC1D22A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 HIST1H3G 8355
Affinity Capture-MS Homo sapiens
32 PIGF  
Affinity Capture-MS Homo sapiens
33 FBXW7  
Synthetic Lethality Homo sapiens
34 PVRIG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PFDN4 5203
Affinity Capture-MS Homo sapiens
36 MDC1  
Affinity Capture-MS Homo sapiens
37 SNRPC 6631
Affinity Capture-MS Homo sapiens
38 SRP19 6728
Co-fractionation Homo sapiens
39 OBSL1 23363
Affinity Capture-MS Homo sapiens
40 DDOST 1650
Affinity Capture-MS Homo sapiens
41 EED  
Affinity Capture-MS Homo sapiens
42 ANAPC7 51434
Co-fractionation Homo sapiens
43 DDX23 9416
Proximity Label-MS Homo sapiens
44 POLR2C 5432
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
45 Ruvbl1 56505
Affinity Capture-MS Mus musculus
46 MECP2 4204
Affinity Capture-MS Homo sapiens
47 POLR2M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ERBB2 2064
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
49 HIST1H3H 8357
Affinity Capture-MS Homo sapiens
50 SLU7  
Affinity Capture-MS Homo sapiens
51 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 GPN3  
Affinity Capture-MS Homo sapiens
53 TSC2 7249
Reconstituted Complex Homo sapiens
54 POLR2K  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PPP1CA 5499
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 HAUS2  
Affinity Capture-MS Homo sapiens
57 SCAF1  
Affinity Capture-MS Homo sapiens
58 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
59 UXT 8409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 EMD 2010
Affinity Capture-MS Homo sapiens
61 CDKN1A  
Affinity Capture-MS Homo sapiens
62 WWP2 11060
Affinity Capture-MS Homo sapiens
63 HIST1H3C 8352
Affinity Capture-MS Homo sapiens
64 SUPT5H 6829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
65 HSP90B1 7184
Reconstituted Complex Homo sapiens
66 PSMD14 10213
Affinity Capture-MS Homo sapiens
67 Pfdn2  
Affinity Capture-MS Mus musculus
68 PFDN2 5202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 IWS1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
70 RPL31 6160
Proximity Label-MS Homo sapiens
71 RAD18  
Affinity Capture-MS Homo sapiens
72 PYCRL 65263
Affinity Capture-MS Homo sapiens
73 CTR9 9646
Affinity Capture-MS Homo sapiens
74 CEP76  
Affinity Capture-MS Homo sapiens
75 FAM168A  
Affinity Capture-MS Homo sapiens
76 Katna1  
Affinity Capture-MS Mus musculus
77 VCP 7415
Affinity Capture-MS Homo sapiens
78 CD3EAP  
Proximity Label-MS Homo sapiens
79 RECQL5  
Affinity Capture-MS Homo sapiens
80 TMPO 7112
Affinity Capture-MS Homo sapiens
81 CEP57  
Affinity Capture-MS Homo sapiens
82 S100P 6286
Affinity Capture-MS Homo sapiens
83 Gtf2e2  
Affinity Capture-MS Mus musculus
84 ATL3 25923
Affinity Capture-MS Homo sapiens
85 BAZ1B 9031
Affinity Capture-MS Homo sapiens
86 C9orf78 51759
Affinity Capture-MS Homo sapiens
87 BAG2 9532
Affinity Capture-MS Homo sapiens
88 SIRT7  
Affinity Capture-MS Homo sapiens
89 SNRPB 6628
Affinity Capture-MS Homo sapiens
90 POLR2E 5434
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 SIRPA 140885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
92 RPRD2  
Affinity Capture-MS Homo sapiens
93 PI15  
Affinity Capture-MS Homo sapiens
94 SGOL1  
Affinity Capture-MS Homo sapiens
95 DDB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 RPRD1A  
Affinity Capture-MS Homo sapiens
97 POLR2D  
Affinity Capture-MS Homo sapiens
98 FUS 2521
Affinity Capture-MS Homo sapiens
99 H3F3B 3021
Affinity Capture-MS Homo sapiens
100 PDCD11 22984
Co-fractionation Homo sapiens
101 POLR2A 5430
Far Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
102 CCDC71  
Affinity Capture-MS Homo sapiens
103 POLR3E 55718
Affinity Capture-MS Homo sapiens
104 VBP1 7411
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 STRAP 11171
Affinity Capture-MS Homo sapiens
106 HIST1H3B 8358
Affinity Capture-MS Homo sapiens
107 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
108 CEP250 11190
Affinity Capture-MS Homo sapiens
109 CTCFL  
Affinity Capture-MS Homo sapiens
110 RNF145  
Affinity Capture-MS Homo sapiens
111 GNB2 2783
Affinity Capture-MS Homo sapiens
112 EGFR 1956
Reconstituted Complex Homo sapiens
Negative Genetic Homo sapiens
113 TOP1 7150
Affinity Capture-MS Homo sapiens
114 HSPA1A 3303
Affinity Capture-MS Homo sapiens
115 RPAP3 79657
Affinity Capture-MS Homo sapiens
116 POLR1A  
Affinity Capture-MS Homo sapiens
117 WSB2 55884
Affinity Capture-MS Homo sapiens
118 BMI1  
Affinity Capture-MS Homo sapiens
119 HSPA4 3308
Co-fractionation Homo sapiens
120 HSPD1 3329
Reconstituted Complex Homo sapiens
121 AKT1 207
Reconstituted Complex Homo sapiens
122 HSPA9 3313
Reconstituted Complex Homo sapiens
123 NFATC2  
Affinity Capture-MS Homo sapiens
124 SLC39A1 27173
Affinity Capture-MS Homo sapiens
125 FTSJ3 117246
Affinity Capture-MS Homo sapiens
126 OST4  
Affinity Capture-MS Homo sapiens
127 H2AFX 3014
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 HIST1H3J 8356
Affinity Capture-MS Homo sapiens
129 ZRANB1 54764
Affinity Capture-MS Homo sapiens
130 EXOSC10 5394
Co-fractionation Homo sapiens
131 SLC35G1  
Affinity Capture-MS Homo sapiens
132 CPSF6 11052
Affinity Capture-MS Homo sapiens
133 Ruvbl2 20174
Affinity Capture-MS Mus musculus
134 GAB1  
Reconstituted Complex Homo sapiens
135 POLR2F  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 SIRT6  
Affinity Capture-MS Homo sapiens
137 PARP1 142
Proximity Label-MS Homo sapiens
138 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 TP53 7157
Affinity Capture-MS Homo sapiens
140 TUBG1 7283
Affinity Capture-MS Homo sapiens
141 RUVBL2 10856
Affinity Capture-MS Homo sapiens
142 POLR2L 5441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 PIN1 5300
Affinity Capture-MS Homo sapiens
144 PHRF1  
Affinity Capture-MS Homo sapiens
145 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
146 RPAP2  
Affinity Capture-MS Homo sapiens
147 LMO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 S100A10 6281
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
149 RNF20 56254
Affinity Capture-Western Homo sapiens
150 SUPT4H1  
Co-fractionation Homo sapiens
151 PDIA4 9601
Cross-Linking-MS (XL-MS) Homo sapiens
152 DDX58 23586
Affinity Capture-RNA Homo sapiens
153 ESR1  
Affinity Capture-Western Homo sapiens
154 DHX40  
Proximity Label-MS Homo sapiens
155 SKAP1 8631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 NUP50 10762
Proximity Label-MS Homo sapiens
157 NCL 4691
Co-fractionation Homo sapiens
158 Rprd1b  
Affinity Capture-MS Mus musculus
159 TTC29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 CIT 11113
Affinity Capture-MS Homo sapiens
161 EP300 2033
Affinity Capture-MS Homo sapiens
162 RPRD1B 58490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 STK11 6794
Affinity Capture-MS Homo sapiens
164 PIH1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 STT3B 201595
Affinity Capture-MS Homo sapiens
166 CUL7 9820
Affinity Capture-MS Homo sapiens
167 KRAS 3845
Negative Genetic Homo sapiens
168 SRP9 6726
Affinity Capture-MS Homo sapiens
169 KRTAP13-3  
Affinity Capture-MS Homo sapiens
170 SSRP1 6749
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 RPA3 6119
Proximity Label-MS Homo sapiens
172 KIAA0408  
Affinity Capture-MS Homo sapiens
173 DCAF5  
Affinity Capture-MS Homo sapiens
174 ZBTB44  
Affinity Capture-MS Homo sapiens
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