Gene description for EXOSC10
Gene name exosome component 10
Gene symbol EXOSC10
Other names/aliases PM-Scl
PM/Scl-100
PMSCL
PMSCL2
RRP6
Rrp6p
p2
p3
p4
Species Homo sapiens
 Database cross references - EXOSC10
ExoCarta ExoCarta_5394
Vesiclepedia VP_5394
Entrez Gene 5394
HGNC 9138
MIM 605960
UniProt Q01780  
 EXOSC10 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EXOSC10
Molecular Function
    nucleotide binding GO:0000166 IEA
    3'-5'-RNA exonuclease activity GO:0000175 IBA
    3'-5'-RNA exonuclease activity GO:0000175 IMP
    3'-5'-RNA exonuclease activity GO:0000175 TAS
    RNA binding GO:0003723 HDA
    single-stranded RNA binding GO:0003727 IBA
    RNA exonuclease activity GO:0004532 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    telomerase RNA binding GO:0070034 IPI
Biological Process
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 IEA
    maturation of 5.8S rRNA GO:0000460 IMP
    exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000467 IBA
    nuclear-transcribed mRNA catabolic process GO:0000956 IMP
    DNA repair GO:0006281 IEA
    rRNA processing GO:0006364 TAS
    RNA processing GO:0006396 IDA
    RNA catabolic process GO:0006401 IDA
    negative regulation of telomere maintenance via telomerase GO:0032211 IMP
    ribosomal small subunit biogenesis GO:0042274 IDA
    nuclear mRNA surveillance GO:0071028 IMP
    CUT catabolic process GO:0071034 IMP
    nuclear polyadenylation-dependent rRNA catabolic process GO:0071035 IBA
    nuclear polyadenylation-dependent rRNA catabolic process GO:0071035 IMP
    nuclear polyadenylation-dependent snoRNA catabolic process GO:0071036 IBA
    nuclear polyadenylation-dependent snRNA catabolic process GO:0071037 IBA
    TRAMP-dependent tRNA surveillance pathway GO:0071038 IBA
    nuclear polyadenylation-dependent CUT catabolic process GO:0071039 IBA
    nuclear polyadenylation-dependent antisense transcript catabolic process GO:0071040 IBA
    histone mRNA catabolic process GO:0071044 IBA
    histone mRNA catabolic process GO:0071044 IMP
    poly(A)-dependent snoRNA 3'-end processing GO:0071051 IBA
    regulation of telomerase RNA localization to Cajal body GO:1904872 IMP
    positive regulation of mRNA cis splicing, via spliceosome GO:1905746 IEA
Subcellular Localization
    nuclear exosome (RNase complex) GO:0000176 IBA
    nuclear exosome (RNase complex) GO:0000176 IDA
    nuclear exosome (RNase complex) GO:0000176 NAS
    cytoplasmic exosome (RNase complex) GO:0000177 NAS
    exosome (RNase complex) GO:0000178 IDA
    euchromatin GO:0000791 IMP
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    membrane GO:0016020 HDA
    small-subunit processome GO:0032040 IDA
    nucleolar exosome (RNase complex) GO:0101019 NAS
 Experiment description of studies that identified EXOSC10 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EXOSC10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 EXOSC7 23016
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 DIS3 22894
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
5 KPNA1 3836
Cross-Linking-MS (XL-MS) Homo sapiens
6 TARDBP 23435
Two-hybrid Homo sapiens
7 RPA2 6118
Affinity Capture-MS Homo sapiens
8 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
9 RPL15 6138
Affinity Capture-MS Homo sapiens
10 USP16  
Two-hybrid Homo sapiens
11 SSB 6741
Co-fractionation Homo sapiens
12 XRN2 22803
Two-hybrid Homo sapiens
13 CAND1 55832
Affinity Capture-MS Homo sapiens
14 HNRNPR 10236
Co-fractionation Homo sapiens
15 EIF4E2  
Affinity Capture-MS Homo sapiens
16 SOX2  
Affinity Capture-MS Homo sapiens
17 USP36  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
18 PARK2  
Affinity Capture-MS Homo sapiens
19 FERMT3 83706
Two-hybrid Homo sapiens
20 EXOSC2 23404
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 C1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FBXW7  
Affinity Capture-MS Homo sapiens
23 SCRIB 23513
Two-hybrid Homo sapiens
24 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ANOS1 3730
Affinity Capture-MS Homo sapiens
26 POU5F1  
Affinity Capture-MS Homo sapiens
27 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 EXOSC4 54512
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
29 SLX4  
Affinity Capture-MS Homo sapiens
30 EXOSC6 118460
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
31 MECP2 4204
Affinity Capture-MS Homo sapiens
32 SKIV2L 6499
Two-hybrid Homo sapiens
33 MPHOSPH6 10200
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 RBM8A 9939
Affinity Capture-MS Homo sapiens
35 KIF14 9928
Affinity Capture-MS Homo sapiens
36 EXOSC9 5393
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 LSM2 57819
Two-hybrid Homo sapiens
38 PTGES2 80142
Two-hybrid Homo sapiens
39 DIS3L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 NOMO1 23420
Two-hybrid Homo sapiens
41 UTP14A 10813
Co-fractionation Homo sapiens
42 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
43 USP21  
Two-hybrid Homo sapiens
44 RPL4 6124
Affinity Capture-MS Homo sapiens
45 DRG1 4733
Affinity Capture-MS Homo sapiens
46 XRN1 54464
Two-hybrid Homo sapiens
47 RBM7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RPE  
Two-hybrid Homo sapiens
49 RPL5 6125
Affinity Capture-MS Homo sapiens
50 RPL18A 6142
Affinity Capture-MS Homo sapiens
51 NTRK1 4914
Affinity Capture-MS Homo sapiens
52 RPL31 6160
Proximity Label-MS Homo sapiens
53 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 DXO  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
55 EXOSC5 56915
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 SUMO2 6613
Reconstituted Complex Homo sapiens
57 NCL 4691
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
58 CIB1 10519
Two-hybrid Homo sapiens
59 RPS6 6194
Proximity Label-MS Homo sapiens
60 HECTD1 25831
Affinity Capture-MS Homo sapiens
61 MAGEB2 4113
Affinity Capture-MS Homo sapiens
62 SUPT6H 6830
Co-fractionation Homo sapiens
63 CEBPA  
Protein-peptide Homo sapiens
64 Exosc1  
Affinity Capture-MS Mus musculus
65 CD3EAP  
Proximity Label-MS Homo sapiens
66 ZCCHC8 55596
Affinity Capture-MS Homo sapiens
67 CHPF 79586
Two-hybrid Homo sapiens
68 SFPQ 6421
Affinity Capture-MS Homo sapiens
69 NOMO2 283820
Two-hybrid Homo sapiens
70 LSM8 51691
Two-hybrid Homo sapiens
71 HBS1L 10767
Affinity Capture-MS Homo sapiens
72 B9D1 27077
Two-hybrid Homo sapiens
73 C9orf78 51759
Affinity Capture-MS Homo sapiens
74 RC3H2  
Affinity Capture-MS Homo sapiens
75 SIRT7  
Affinity Capture-MS Homo sapiens
76 CUL3 8452
Affinity Capture-MS Homo sapiens
77 Rrbp1  
Affinity Capture-MS Mus musculus
78 TOX4  
Two-hybrid Homo sapiens
79 UPF3A  
Affinity Capture-Western Homo sapiens
80 NXF1 10482
Affinity Capture-RNA Homo sapiens
81 PSPC1 55269
Affinity Capture-MS Homo sapiens
82 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
83 ZC3H18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 DNAJC9 23234
Proximity Label-MS Homo sapiens
85 EXOSC3 51010
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
86 FOXRED1  
Two-hybrid Homo sapiens
87 SKIV2L2 23517
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
88 DDRGK1 65992
Affinity Capture-MS Homo sapiens
89 RNF185  
Affinity Capture-MS Homo sapiens
90 NANOG  
Affinity Capture-MS Homo sapiens
91 UPF2 26019
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
92 C9orf72  
Affinity Capture-MS Homo sapiens
93 RPS16 6217
Affinity Capture-MS Homo sapiens
94 IMMT 10989
Two-hybrid Homo sapiens
95 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
96 GIGYF2 26058
Affinity Capture-MS Homo sapiens
97 SIRT6  
Affinity Capture-MS Homo sapiens
98 MPP6 51678
Two-hybrid Homo sapiens
99 HDGF 3068
Affinity Capture-MS Homo sapiens
100 TP53 7157
Affinity Capture-MS Homo sapiens
101 RUVBL2 10856
Two-hybrid Homo sapiens
102 MNDA 4332
Affinity Capture-MS Homo sapiens
103 RPA1 6117
Affinity Capture-MS Homo sapiens
104 ALDH1B1 219
Two-hybrid Homo sapiens
105 THOP1 7064
Affinity Capture-MS Homo sapiens
106 SMURF1 57154
Affinity Capture-MS Homo sapiens
107 LCAT 3931
Two-hybrid Homo sapiens
108 NIFK 84365
Proximity Label-MS Homo sapiens
109 ESR1  
Affinity Capture-MS Homo sapiens
110 UFL1 23376
Affinity Capture-MS Homo sapiens
111 RPS24 6229
Proximity Label-MS Homo sapiens
112 MOV10 4343
Affinity Capture-RNA Homo sapiens
113 EIF3M 10480
Two-hybrid Homo sapiens
114 UPF1 5976
Affinity Capture-Western Homo sapiens
115 CIT 11113
Affinity Capture-MS Homo sapiens
116 SNW1 22938
Affinity Capture-MS Homo sapiens
117 KRAS 3845
Negative Genetic Homo sapiens
118 HNRNPU 3192
Affinity Capture-MS Homo sapiens
119 GNB2L1 10399
Affinity Capture-MS Homo sapiens
120 AR 367
Proximity Label-MS Homo sapiens
121 RC3H1 149041
Affinity Capture-MS Homo sapiens
122 SSRP1 6749
Two-hybrid Homo sapiens
123 PRMT1 3276
Affinity Capture-MS Homo sapiens
124 EXOSC1 51013
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 EXOSC8  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
126 CDC5L 988
Affinity Capture-MS Homo sapiens
127 PARN  
Co-fractionation Homo sapiens
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