Gene description for EXOSC10
Gene name exosome component 10
Gene symbol EXOSC10
Other names/aliases PM-Scl
PM/Scl-100
PMSCL
PMSCL2
RRP6
Rrp6p
p2
p3
p4
Species Homo sapiens
 Database cross references - EXOSC10
ExoCarta ExoCarta_5394
Vesiclepedia VP_5394
Entrez Gene 5394
HGNC 9138
MIM 605960
UniProt Q01780  
 EXOSC10 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EXOSC10
Molecular Function
    nucleotide binding GO:0000166 IEA
    exoribonuclease activity GO:0004532 IDA
    poly(A) RNA binding GO:0044822 IDA
    3'-5' exonuclease activity GO:0008408 IEA
    protein binding GO:0005515 IPI
Biological Process
    dosage compensation by inactivation of X chromosome GO:0009048 IEA
    CUT catabolic process GO:0071034 IMP
    nuclear-transcribed mRNA catabolic process GO:0000956 IMP
    nuclear mRNA surveillance GO:0071028 IMP
    nuclear polyadenylation-dependent rRNA catabolic process GO:0071035 IMP
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 IMP
    maturation of 5.8S rRNA GO:0000460 IMP
    RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503 IDA
    nuclear retention of unspliced pre-mRNA at the site of transcription GO:0071048 IMP
    histone mRNA catabolic process GO:0071044 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    transcriptionally active chromatin GO:0035327 IMP
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IDA
    exosome (RNase complex) GO:0000178 IDA
    nuclear exosome (RNase complex) GO:0000176 IEA
 Experiment description of studies that identified EXOSC10 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EXOSC10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TARDBP 23435
Two-hybrid Homo sapiens
2 PTGES2 80142
Two-hybrid Homo sapiens
3 CIB1 10519
Two-hybrid Homo sapiens
4 SCRIB 23513
Two-hybrid Homo sapiens
5 RPE  
Two-hybrid Homo sapiens
6 MPP6 51678
Two-hybrid Homo sapiens
7 USP16  
Two-hybrid Homo sapiens
8 UPF2 26019
Affinity Capture-Western Homo sapiens
9 UPF1 5976
Affinity Capture-Western Homo sapiens
10 UPF3A  
Affinity Capture-Western Homo sapiens
11 XRN2 22803
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which EXOSC10 is involved
No pathways found





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