Gene description for LCAT
Gene name lecithin-cholesterol acyltransferase
Gene symbol LCAT
Other names/aliases -
Species Homo sapiens
 Database cross references - LCAT
ExoCarta ExoCarta_3931
Entrez Gene 3931
HGNC 6522
MIM 606967
UniProt P04180  
 LCAT identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for LCAT
Molecular Function
    phosphatidylcholine-sterol O-acyltransferase activity GO:0004607 NAS
    apolipoprotein A-I binding GO:0034186 IPI
    protein binding GO:0005515 IPI
Biological Process
    phosphatidylcholine biosynthetic process GO:0006656 IDA
    very-low-density lipoprotein particle remodeling GO:0034372 IDA
    regulation of high-density lipoprotein particle assembly GO:0090107 IEA
    phospholipid metabolic process GO:0006644 IDA
    lipoprotein metabolic process GO:0042157 TAS
    cholesterol metabolic process GO:0008203 IDA
    high-density lipoprotein particle remodeling GO:0034375 IDA
    cholesterol homeostasis GO:0042632 IDA
    small molecule metabolic process GO:0044281 TAS
    lipoprotein biosynthetic process GO:0042158 IEA
    cholesterol transport GO:0030301 IDA
    reverse cholesterol transport GO:0043691 IDA
    cholesterol esterification GO:0034435 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    high-density lipoprotein particle GO:0034364 IDA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified LCAT in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LCAT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 A2M 2
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 APOA1 335
Invivo Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LCAT is involved
HDL-mediated lipid transport TAS Reactome

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