Gene description for APOA1
Gene name apolipoprotein A-I
Gene symbol APOA1
Other names/aliases -
Species Homo sapiens
 Database cross references - APOA1
ExoCarta ExoCarta_335
Vesiclepedia VP_335
Entrez Gene 335
HGNC 600
MIM 107680
UniProt P02647  
 APOA1 identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Liver cancer cells 25265333    
Liver cancer cells 25265333    
Liver cancer cells 25265333    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Plasma 36624553    
Plasma 36624553    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 22723089    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Saliva 19199708    
Serum 36517516    
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for APOA1
Molecular Function
    amyloid-beta binding GO:0001540 IDA
    amyloid-beta binding GO:0001540 IPI
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    phospholipid binding GO:0005543 IBA
    phospholipid binding GO:0005543 IDA
    high-density lipoprotein particle binding GO:0008035 IEA
    cholesterol binding GO:0015485 IDA
    enzyme binding GO:0019899 IPI
    heat shock protein binding GO:0031072 IPI
    apolipoprotein receptor binding GO:0034190 IPI
    apolipoprotein A-I receptor binding GO:0034191 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 ISS
    chemorepellent activity GO:0045499 IDA
    receptor ligand activity GO:0048018 IDA
    phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IBA
    phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IDA
    high-density lipoprotein particle receptor binding GO:0070653 IPI
    cholesterol transfer activity GO:0120020 IDA
    cholesterol transfer activity GO:0120020 IMP
Biological Process
    endothelial cell proliferation GO:0001935 IEA
    negative regulation of cytokine production involved in immune response GO:0002719 IDA
    phosphatidylcholine biosynthetic process GO:0006656 IDA
    cholesterol biosynthetic process GO:0006695 IEA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    integrin-mediated signaling pathway GO:0007229 IDA
    cholesterol metabolic process GO:0008203 IBA
    cholesterol metabolic process GO:0008203 IMP
    glucocorticoid metabolic process GO:0008211 IEA
    negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 IDA
    positive regulation of cholesterol efflux GO:0010875 IDA
    negative regulation of very-low-density lipoprotein particle remodeling GO:0010903 IDA
    protein oxidation GO:0018158 IDA
    peptidyl-methionine modification GO:0018206 IDA
    lipid storage GO:0019915 IEA
    regulation of intestinal cholesterol absorption GO:0030300 IEA
    cholesterol transport GO:0030301 IDA
    adrenal gland development GO:0030325 IEA
    regulation of Cdc42 protein signal transduction GO:0032489 IDA
    negative regulation of interleukin-1 beta production GO:0032691 IDA
    cholesterol efflux GO:0033344 IBA
    cholesterol efflux GO:0033344 IDA
    cholesterol efflux GO:0033344 IMP
    phospholipid efflux GO:0033700 IBA
    phospholipid efflux GO:0033700 IDA
    negative regulation of heterotypic cell-cell adhesion GO:0034115 IDA
    high-density lipoprotein particle remodeling GO:0034375 IDA
    high-density lipoprotein particle assembly GO:0034380 IDA
    high-density lipoprotein particle clearance GO:0034384 IC
    positive regulation of Rho protein signal transduction GO:0035025 IDA
    lipoprotein biosynthetic process GO:0042158 IEA
    cholesterol homeostasis GO:0042632 IDA
    cholesterol homeostasis GO:0042632 IMP
    blood vessel endothelial cell migration GO:0043534 IEA
    reverse cholesterol transport GO:0043691 IMP
    negative regulation of inflammatory response GO:0050728 IDA
    positive regulation of phagocytosis GO:0050766 IDA
    protein stabilization GO:0050821 IDA
    negative chemotaxis GO:0050919 IDA
    vitamin transport GO:0051180 IMP
    positive regulation of hydrolase activity GO:0051345 IDA
    positive regulation of stress fiber assembly GO:0051496 IDA
    acylglycerol homeostasis GO:0055090 IBA
    phospholipid homeostasis GO:0055091 IDA
    negative regulation of cell adhesion molecule production GO:0060354 IDA
    negative regulation of response to cytokine stimulus GO:0060761 IDA
    triglyceride homeostasis GO:0070328 IDA
    ERK1 and ERK2 cascade GO:0070371 IDA
    cholesterol import GO:0070508 IMP
    cellular response to lipoprotein particle stimulus GO:0071402 IDA
    positive regulation of cholesterol metabolic process GO:0090205 IDA
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IDA
    positive regulation of phospholipid efflux GO:1902995 IDA
    positive regulation of CoA-transferase activity GO:1905920 IDA
Subcellular Localization
    extracellular region GO:0005576 HDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISS
    early endosome GO:0005769 TAS
    endoplasmic reticulum lumen GO:0005788 TAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    endocytic vesicle GO:0030139 IDA
    cytoplasmic vesicle GO:0031410 IDA
    very-low-density lipoprotein particle GO:0034361 IBA
    very-low-density lipoprotein particle GO:0034361 IDA
    low-density lipoprotein particle GO:0034362 IBA
    high-density lipoprotein particle GO:0034364 IBA
    high-density lipoprotein particle GO:0034364 IDA
    high-density lipoprotein particle GO:0034364 TAS
    spherical high-density lipoprotein particle GO:0034366 IDA
    secretory granule lumen GO:0034774 TAS
    chylomicron GO:0042627 IBA
    collagen-containing extracellular matrix GO:0062023 HDA
    extracellular exosome GO:0070062 HDA
    endocytic vesicle lumen GO:0071682 TAS
    blood microparticle GO:0072562 HDA
    extracellular vesicle GO:1903561 HDA
    extracellular vesicle GO:1903561 IBA
 Experiment description of studies that identified APOA1 in sEVs
1
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
6
Experiment ID 285
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
7
Experiment ID 286
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
8
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
9
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
10
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
11
Experiment ID 266
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Wild type
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 267
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 268
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx-null HBV replicon plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 254
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
22
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
23
Experiment ID 606
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|HSP90|TSG101|GAPDH
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Western blotting
PubMed ID 36624553    
Organism Homo sapiens
Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles
Authors "Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. "
Journal name Proteomics
Publication year 2023
Sample Plasma
Sample name Plasma - Ion exchange adsorption 12.5 mg
Isolation/purification methods Filtration
Size exclusion chromatography
Ion exchange adsorption
Centrifugation
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 606
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|HSP90|TSG101|GAPDH
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36624553    
Organism Homo sapiens
Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles
Authors "Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. "
Journal name Proteomics
Publication year 2023
Sample Plasma
Sample name Plasma - Ion exchange adsorption 12.5 mg
Isolation/purification methods Filtration
Size exclusion chromatography
Ion exchange adsorption
Centrifugation
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
25
Experiment ID 607
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|HSP90|TSG101|GAPDH
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Western blotting
PubMed ID 36624553    
Organism Homo sapiens
Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles
Authors "Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. "
Journal name Proteomics
Publication year 2023
Sample Plasma
Sample name Plasma - Ion exchange adsorption 25 mg
Isolation/purification methods Filtration
Size exclusion chromatography
Ion exchange adsorption
Centrifugation
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
26
Experiment ID 607
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|HSP90|TSG101|GAPDH
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36624553    
Organism Homo sapiens
Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles
Authors "Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. "
Journal name Proteomics
Publication year 2023
Sample Plasma
Sample name Plasma - Ion exchange adsorption 25 mg
Isolation/purification methods Filtration
Size exclusion chromatography
Ion exchange adsorption
Centrifugation
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
27
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
29
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
31
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
32
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
35
Experiment ID 457
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|TSG101
Enriched markers
✔
CALR
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 36517516    
Organism Homo sapiens
Experiment description Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes
Authors "Zhao D, Wu K, Sharma S, Xing F, Wu SY, Tyagi A, Deshpande R, Singh R, Wabitsch M, Mo YY, Watabe K."
Journal name Nat Commun
Publication year 2022
Sample Serum
Sample name Breast cancer patients - African American
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
36
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
37
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for APOA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MIS12  
Affinity Capture-MS Homo sapiens
2 SMPDL3A 10924
Affinity Capture-MS Homo sapiens
3 KLHL28  
Affinity Capture-MS Homo sapiens
4 HBB 3043
Affinity Capture-MS Homo sapiens
5 STATH  
Affinity Capture-MS Homo sapiens
6 KRT1 3848
Affinity Capture-MS Homo sapiens
7 CMTM5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 ABCA13  
Reconstituted Complex Homo sapiens
9 GJA1 2697
Affinity Capture-MS Homo sapiens
10 TTR 7276
Affinity Capture-MS Homo sapiens
11 Papss1  
Affinity Capture-MS Mus musculus
12 ALB 213
Affinity Capture-MS Homo sapiens
13 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ABCA1 19
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
15 SETX  
Affinity Capture-MS Homo sapiens
16 ITIH2 3698
Cross-Linking-MS (XL-MS) Homo sapiens
17 TFPI 7035
Cross-Linking-MS (XL-MS) Homo sapiens
18 KRT73 319101
Cross-Linking-MS (XL-MS) Homo sapiens
19 HYPK 25764
Affinity Capture-MS Homo sapiens
20 SOX2  
Affinity Capture-MS Homo sapiens
21 FNDC5  
Affinity Capture-MS Homo sapiens
22 APOD 347
Cross-Linking-MS (XL-MS) Homo sapiens
23 HPX 3263
Affinity Capture-MS Homo sapiens
24 APOC1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
25 HP 3240
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
26 CLEC4G  
Two-hybrid Homo sapiens
27 FGA 2243
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
28 ABCA6 23460
Affinity Capture-MS Homo sapiens
29 NDRG1 10397
Two-hybrid Homo sapiens
FRET Homo sapiens
30 APOC3 345
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
31 TLN1 7094
Cross-Linking-MS (XL-MS) Homo sapiens
32 EGFL8  
Affinity Capture-MS Homo sapiens
33 VKORC1 79001
Two-hybrid Homo sapiens
34 OR13C3  
Affinity Capture-MS Homo sapiens
35 GPLD1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
36 SFXN4  
Affinity Capture-MS Homo sapiens
37 SCARB1 949
Reconstituted Complex Homo sapiens
38 UCHL5 51377
Affinity Capture-MS Homo sapiens
39 PHF11 51131
Affinity Capture-MS Homo sapiens
40 VCAM1 7412
Affinity Capture-MS Homo sapiens
41 FNDC1 84624
Affinity Capture-MS Homo sapiens
42 PDE1A  
Two-hybrid Homo sapiens
43 MYH6 4624
Cross-Linking-MS (XL-MS) Homo sapiens
44 SPEF2 79925
Affinity Capture-MS Homo sapiens
45 SERPINA1 5265
Affinity Capture-MS Homo sapiens
46 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PCYOX1 51449
Cross-Linking-MS (XL-MS) Homo sapiens
48 APOC2 344
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
49 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 GNG8  
Affinity Capture-MS Homo sapiens
52 C1QC 714
Affinity Capture-MS Homo sapiens
53 FBLN1 2192
Two-hybrid Homo sapiens
54 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
55 WHSC1 7468
Affinity Capture-MS Homo sapiens
56 CLU 1191
Affinity Capture-MS Homo sapiens
57 ROBO3  
Affinity Capture-MS Homo sapiens
58 A2M 2
Cross-Linking-MS (XL-MS) Homo sapiens
59 GOLGA8A 23015
Affinity Capture-MS Homo sapiens
60 AHNAK 79026
Cross-Linking-MS (XL-MS) Homo sapiens
61 TMEM43 79188
Affinity Capture-MS Homo sapiens
62 C1QA 712
Affinity Capture-MS Homo sapiens
63 VCP 7415
Affinity Capture-Western Homo sapiens
64 CFAP54  
Cross-Linking-MS (XL-MS) Homo sapiens
65 APOA2 336
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
66 KRT9 3857
Affinity Capture-MS Homo sapiens
67 U2AF2 11338
Affinity Capture-MS Homo sapiens
68 TOMM20 9804
Two-hybrid Homo sapiens
69 APOL1 8542
Co-purification Homo sapiens
70 PRR4 11272
Affinity Capture-MS Homo sapiens
71 GDPD1 284161
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 ITGB2 3689
Cross-Linking-MS (XL-MS) Homo sapiens
73 TNFRSF10C  
Two-hybrid Homo sapiens
74 LCN1 3933
Affinity Capture-MS Homo sapiens
75 ATP4A 495
Affinity Capture-MS Homo sapiens
76 RRP1B 23076
Affinity Capture-MS Homo sapiens
77 BRAP  
Two-hybrid Homo sapiens
78 DDX39B 7919
Affinity Capture-MS Homo sapiens
79 SAFB2 9667
Affinity Capture-MS Homo sapiens
80 SERPINA3 12
Cross-Linking-MS (XL-MS) Homo sapiens
81 IGKC 3514
Affinity Capture-MS Homo sapiens
82 HBA1 3039
Affinity Capture-MS Homo sapiens
83 KIAA0754  
Affinity Capture-MS Homo sapiens
84 FAM83C  
Affinity Capture-MS Homo sapiens
85 APOF 319
Co-purification Homo sapiens
86 SARAF  
Affinity Capture-MS Homo sapiens
87 KRT3 3850
Cross-Linking-MS (XL-MS) Homo sapiens
88 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
89 FANCD2  
Affinity Capture-MS Homo sapiens
90 HMGCLL1  
Affinity Capture-MS Homo sapiens
91 AGPAT1 10554
Affinity Capture-MS Homo sapiens
92 ITLN2  
Affinity Capture-MS Homo sapiens
93 APOB 338
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
94 QDPR 5860
Affinity Capture-MS Homo sapiens
95 CIR1  
Affinity Capture-MS Homo sapiens
96 NR3C1 2908
Affinity Capture-MS Homo sapiens
97 CP 1356
Affinity Capture-MS Homo sapiens
98 UPF3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 TNS3 64759
Affinity Capture-MS Homo sapiens
100 FN1 2335
Affinity Capture-MS Homo sapiens
101 MAP7D1 55700
Two-hybrid Homo sapiens
102 MAPK6  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 ZNF558  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 C6 729
Cross-Linking-MS (XL-MS) Homo sapiens
105 GOT1L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 NLRP1  
Affinity Capture-MS Homo sapiens
107 AKT2 208
Two-hybrid Homo sapiens
108 CD40LG 959
Affinity Capture-Western Homo sapiens
109 FAM169A  
Affinity Capture-MS Homo sapiens
110 MYH7 4625
Cross-Linking-MS (XL-MS) Homo sapiens
111 MSN 4478
Cross-Linking-MS (XL-MS) Homo sapiens
112 Lep  
Reconstituted Complex Mus musculus
113 STX17 55014
Affinity Capture-MS Homo sapiens
114 KRT16 3868
Affinity Capture-MS Homo sapiens
115 UBE2U  
Affinity Capture-MS Homo sapiens
116 APP 351
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
117 ORM1 5004
Affinity Capture-MS Homo sapiens
118 APOA1BP 128240
Affinity Capture-Western Homo sapiens
119 SNCA 6622
Affinity Capture-MS Homo sapiens
120 CTSL 1514
Affinity Capture-MS Homo sapiens
121 PDE4B  
Affinity Capture-MS Homo sapiens
122 SCGB1D1  
Affinity Capture-MS Homo sapiens
123 CNN1 1264
Cross-Linking-MS (XL-MS) Homo sapiens
124 MOCOS  
Affinity Capture-MS Homo sapiens
125 SPP1 6696
Two-hybrid Homo sapiens
126 LECT1  
Affinity Capture-MS Homo sapiens
127 SAA1 6288
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
128 LGALS3 3958
Affinity Capture-MS Homo sapiens
129 Cep135  
Affinity Capture-MS Mus musculus
130 LCAT 3931
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
131 ERVK-10  
Affinity Capture-MS Homo sapiens
132 KRT71 112802
Cross-Linking-MS (XL-MS) Homo sapiens
133 PLTP 5360
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
134 PDE6D 5147
Affinity Capture-MS Homo sapiens
135 TF 7018
Affinity Capture-MS Homo sapiens
136 JAK3 3718
Two-hybrid Homo sapiens
137 PTPN5  
Affinity Capture-MS Homo sapiens
138 MBNL1 4154
Affinity Capture-MS Homo sapiens
139 FBLN7  
Affinity Capture-MS Homo sapiens
140 KLK10 5655
Affinity Capture-MS Homo sapiens
141 DNTT 1791
Affinity Capture-MS Homo sapiens
142 FLNA 2316
Cross-Linking-MS (XL-MS) Homo sapiens
143 GOT1 2805
Affinity Capture-MS Homo sapiens
144 SAA2 6289
Cross-Linking-MS (XL-MS) Homo sapiens
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
145 ZNRD1  
Two-hybrid Homo sapiens
146 CUL7 9820
Affinity Capture-MS Homo sapiens
147 DTWD1  
Affinity Capture-MS Homo sapiens
148 IGKV2-40  
Affinity Capture-MS Homo sapiens
149 SAA4 6291
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
150 MATN2 4147
Affinity Capture-MS Homo sapiens
151 CCR1  
Affinity Capture-MS Homo sapiens
152 TXNDC2  
Affinity Capture-MS Homo sapiens
153 P2RX6  
Affinity Capture-MS Homo sapiens
154 LBP 3929
Affinity Capture-Western Homo sapiens
155 SERTAD3  
Affinity Capture-MS Homo sapiens
156 APOA1 335
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
157 PLXDC1  
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which APOA1 is involved
PathwayEvidenceSource
ABC transporter disorders TAS Reactome
ABC transporters in lipid homeostasis TAS Reactome
ABC-family proteins mediated transport TAS Reactome
Amyloid fiber formation TAS Reactome
Binding and Uptake of Ligands by Scavenger Receptors IEA Reactome
Binding and Uptake of Ligands by Scavenger Receptors TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Chylomicron assembly TAS Reactome
Chylomicron remodeling TAS Reactome
Defective ABCA1 causes TGD TAS Reactome
Disease TAS Reactome
Disorders of transmembrane transporters TAS Reactome
HDL assembly TAS Reactome
HDL clearance TAS Reactome
HDL remodeling TAS Reactome
Heme signaling TAS Reactome
Hemostasis TAS Reactome
Metabolism TAS Reactome
Metabolism IEA Reactome
Metabolism of fat-soluble vitamins TAS Reactome
Metabolism of fat-soluble vitamins IEA Reactome
Metabolism of lipids TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of vitamins and cofactors TAS Reactome
Metabolism of vitamins and cofactors IEA Reactome
Plasma lipoprotein assembly TAS Reactome
Plasma lipoprotein assembly, remodeling, and clearance TAS Reactome
Plasma lipoprotein clearance TAS Reactome
Plasma lipoprotein remodeling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet degranulation TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein phosphorylation TAS Reactome
PPARA activates gene expression TAS Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TAS Reactome
Regulation of lipid metabolism by PPARalpha TAS Reactome
Response to elevated platelet cytosolic Ca2+ TAS Reactome
Retinoid metabolism and transport TAS Reactome
Retinoid metabolism and transport IEA Reactome
Scavenging by Class A Receptors TAS Reactome
Scavenging by Class A Receptors IEA Reactome
Scavenging by Class B Receptors IEA Reactome
Scavenging by Class B Receptors TAS Reactome
Scavenging of heme from plasma TAS Reactome
Sensory Perception TAS Reactome
Sensory Perception IEA Reactome
Transport of small molecules TAS Reactome
Vesicle-mediated transport IEA Reactome
Vesicle-mediated transport TAS Reactome
Visual phototransduction TAS Reactome
Visual phototransduction IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here