Gene description for ST6GALNAC6
Gene name ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Gene symbol ST6GALNAC6
Other names/aliases SIAT7-F
SIAT7F
ST6GALNACVI
Species Homo sapiens
 Database cross references - ST6GALNAC6
ExoCarta ExoCarta_30815
Entrez Gene 30815
HGNC 23364
MIM 610135
UniProt Q969X2  
 ST6GALNAC6 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ST6GALNAC6
Molecular Function
    sialyltransferase activity GO:0008373 ISS
    alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity GO:0001665 ISS
Biological Process
    dolichol-linked oligosaccharide biosynthetic process GO:0006488 TAS
    post-translational protein modification GO:0043687 TAS
    glycosylceramide metabolic process GO:0006677 IDA
    ganglioside biosynthetic process GO:0001574 ISS
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    cellular protein metabolic process GO:0044267 TAS
    glycoprotein metabolic process GO:0009100 IDA
    sialylation GO:0097503 ISS
    cell-cell recognition GO:0009988 IC
    oligosaccharide biosynthetic process GO:0009312 ISS
    glycosphingolipid metabolic process GO:0006687 IDA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    plasma membrane GO:0005886 NAS
    Golgi membrane GO:0000139 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified ST6GALNAC6 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ST6GALNAC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ST6GALNAC6 is involved
PathwayEvidenceSource
Sialic acid metabolism TAS Reactome





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