Gene description for IGHG2
Gene name immunoglobulin heavy constant gamma 2 (G2m marker)
Gene symbol IGHG2
Other names/aliases -
Species Homo sapiens
 Database cross references - IGHG2
ExoCarta ExoCarta_3501
Vesiclepedia VP_3501
Entrez Gene 3501
HGNC 5526
MIM 147110
 IGHG2 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 19837982    
Mesenchymal stem cells Unpublished / Not applicable
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Urine 25452312    
 Gene ontology annotations for IGHG2
Molecular Function
    antigen binding GO:0003823 IBA
    protein binding GO:0005515 IPI
    immunoglobulin receptor binding GO:0034987 IBA
Biological Process
    adaptive immune response GO:0002250 NAS
    complement activation, classical pathway GO:0006958 IBA
    antibacterial humoral response GO:0019731 IBA
    B cell receptor signaling pathway GO:0050853 NAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 NAS
    plasma membrane GO:0005886 NAS
    immunoglobulin complex, circulating GO:0042571 IBA
    extracellular exosome GO:0070062 HDA
    IgG immunoglobulin complex GO:0071735 NAS
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified IGHG2 in exosomes
1
Experiment ID 494
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 21
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101|HSP70|CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
6
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
7
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 238
MISEV standards
EM
Biophysical techniques
TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25452312    
Organism Homo sapiens
Experiment description N-linked (N-) glycoproteomics of urimary exosomes
Authors "Saraswat M, Joenvaara S, Musante L, Peltoniemi H4, Holthofer H, Renkonen R."
Journal name Mol Cell Proteomics
Publication year 2014
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Filtration
Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for IGHG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 NRSN1  
Affinity Capture-MS Homo sapiens
3 ALB 213
Affinity Capture-MS Homo sapiens
4 PLSCR4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ARL2BP 23568
Affinity Capture-MS Homo sapiens
6 ZNF354C  
Affinity Capture-MS Homo sapiens
7 EBF2  
Affinity Capture-MS Homo sapiens
8 FNDC5  
Affinity Capture-MS Homo sapiens
9 HSPA5 3309
Affinity Capture-MS Homo sapiens
10 USP36  
Affinity Capture-MS Homo sapiens
11 EGFL8  
Affinity Capture-MS Homo sapiens
12 CA8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CCNA2 890
Affinity Capture-MS Homo sapiens
14 UGT1A10  
Affinity Capture-MS Homo sapiens
15 CIDEA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SFXN4  
Affinity Capture-MS Homo sapiens
17 CYP3A5  
Affinity Capture-MS Homo sapiens
18 PHF11 51131
Affinity Capture-MS Homo sapiens
19 MSL2  
Affinity Capture-MS Homo sapiens
20 FNDC1 84624
Affinity Capture-MS Homo sapiens
21 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 GPN1  
Affinity Capture-MS Homo sapiens
23 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ICE2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 C18orf21  
Affinity Capture-MS Homo sapiens
26 GAR1 54433
Affinity Capture-MS Homo sapiens
27 FCF1  
Affinity Capture-MS Homo sapiens
28 ZFPL1 7542
Affinity Capture-MS Homo sapiens
29 CCT2 10576
Affinity Capture-MS Homo sapiens
30 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GNG8  
Affinity Capture-MS Homo sapiens
33 ATF7IP 55729
Affinity Capture-MS Homo sapiens
34 RAD51AP1  
Affinity Capture-MS Homo sapiens
35 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
36 PARK2  
Affinity Capture-MS Homo sapiens
37 PLK2  
Affinity Capture-MS Homo sapiens
38 FUNDC2 65991
Affinity Capture-MS Homo sapiens
39 CERS3  
Affinity Capture-MS Homo sapiens
40 RNF115  
Affinity Capture-MS Homo sapiens
41 SRRT 51593
Affinity Capture-MS Homo sapiens
42 GRAMD4 23151
Affinity Capture-MS Homo sapiens
43 PMAIP1  
Affinity Capture-MS Homo sapiens
44 IGHG1 3500
Affinity Capture-MS Homo sapiens
45 SARAF  
Affinity Capture-MS Homo sapiens
46 PIGT 51604
Affinity Capture-MS Homo sapiens
47 SSUH2  
Affinity Capture-MS Homo sapiens
48 YWHAQ 10971
Affinity Capture-MS Homo sapiens
49 ALDH3A1 218
Affinity Capture-MS Homo sapiens
50 AKR1A1 10327
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 HCN1  
Affinity Capture-MS Homo sapiens
52 UPK1A 11045
Affinity Capture-MS Homo sapiens
53 STAMBP 10617
Affinity Capture-MS Homo sapiens
54 DKK2  
Affinity Capture-MS Homo sapiens
55 UPP1 7378
Affinity Capture-MS Homo sapiens
56 ACD  
Affinity Capture-MS Homo sapiens
57 STK3 6788
Affinity Capture-MS Homo sapiens
58 RHBDD1 84236
Affinity Capture-MS Homo sapiens
59 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
60 METTL14  
Affinity Capture-MS Homo sapiens
61 AGPAT1 10554
Affinity Capture-MS Homo sapiens
62 ATF6  
Affinity Capture-MS Homo sapiens
63 ASCC1 51008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 TBC1D22B  
Affinity Capture-MS Homo sapiens
65 ITLN2  
Affinity Capture-MS Homo sapiens
66 IGKC 3514
Cross-Linking-MS (XL-MS) Homo sapiens
67 HSD17B10 3028
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 MORF4L1  
Affinity Capture-MS Homo sapiens
69 SUSD3 203328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 MAPK6  
Affinity Capture-MS Homo sapiens
71 FRMD1  
Affinity Capture-MS Homo sapiens
72 SAV1  
Affinity Capture-MS Homo sapiens
73 TIGAR 57103
Affinity Capture-MS Homo sapiens
74 DDRGK1 65992
Affinity Capture-MS Homo sapiens
75 STK4 6789
Affinity Capture-MS Homo sapiens
76 IGHV4-31 28396
Affinity Capture-MS Homo sapiens
77 STX17 55014
Affinity Capture-MS Homo sapiens
78 RIPPLY3  
Affinity Capture-MS Homo sapiens
79 UBE2U  
Affinity Capture-MS Homo sapiens
80 AHSA1 10598
Affinity Capture-MS Homo sapiens
81 CCBL1 883
Affinity Capture-MS Homo sapiens
82 CIR1  
Affinity Capture-MS Homo sapiens
83 KIAA0907  
Affinity Capture-MS Homo sapiens
84 FAM175B 23172
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 SLC25A6 293
Affinity Capture-MS Homo sapiens
86 TP53 7157
Affinity Capture-MS Homo sapiens
87 SCGB1D1  
Affinity Capture-MS Homo sapiens
88 RBM24 221662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 GDPD1 284161
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 EMC4 51234
Affinity Capture-MS Homo sapiens
91 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 SSBP2  
Affinity Capture-MS Homo sapiens
93 PTDSS1 9791
Affinity Capture-MS Homo sapiens
94 PDE6D 5147
Affinity Capture-MS Homo sapiens
95 UFL1 23376
Affinity Capture-MS Homo sapiens
96 MBNL1 4154
Affinity Capture-MS Homo sapiens
97 KLK10 5655
Affinity Capture-MS Homo sapiens
98 PINK1  
Affinity Capture-MS Homo sapiens
99 GOT1 2805
Affinity Capture-MS Homo sapiens
100 METTL3  
Affinity Capture-MS Homo sapiens
101 IGHG3 3502
Affinity Capture-MS Homo sapiens
102 SERBP1 26135
Affinity Capture-MS Homo sapiens
103 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 SMIM8  
Affinity Capture-MS Homo sapiens
105 OR2A4 79541
Affinity Capture-MS Homo sapiens
106 VRK3 51231
Affinity Capture-MS Homo sapiens
107 MATN2 4147
Affinity Capture-MS Homo sapiens
108 CCR1  
Affinity Capture-MS Homo sapiens
109 ARMC10 83787
Affinity Capture-MS Homo sapiens
110 P2RX6  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IGHG2 is involved
No pathways found





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