Gene description for IGHG3
Gene name immunoglobulin heavy constant gamma 3 (G3m marker)
Gene symbol IGHG3
Other names/aliases IgG3
Species Homo sapiens
 Database cross references - IGHG3
ExoCarta ExoCarta_3502
Vesiclepedia VP_3502
Entrez Gene 3502
HGNC 5527
MIM 147120
 IGHG3 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
Mesenchymal stem cells Unpublished / Not applicable
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for IGHG3
Molecular Function
    antigen binding GO:0003823 IBA
    immunoglobulin receptor binding GO:0034987 IBA
Biological Process
    adaptive immune response GO:0002250 NAS
    complement activation, classical pathway GO:0006958 IBA
    antibacterial humoral response GO:0019731 IBA
    B cell receptor signaling pathway GO:0050853 NAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 NAS
    plasma membrane GO:0005886 NAS
    immunoglobulin complex, circulating GO:0042571 IBA
    extracellular exosome GO:0070062 HDA
    IgG immunoglobulin complex GO:0071735 NAS
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified IGHG3 in exosomes
1
Experiment ID 21
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101|HSP70|CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
3
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IGHG3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CIR1  
Affinity Capture-MS Homo sapiens
2 GNG8  
Affinity Capture-MS Homo sapiens
3 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RHBDD1 84236
Affinity Capture-MS Homo sapiens
5 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
6 PHF11 51131
Affinity Capture-MS Homo sapiens
7 SLC25A6 293
Affinity Capture-MS Homo sapiens
8 C18orf21  
Affinity Capture-MS Homo sapiens
9 FANCD2  
Affinity Capture-MS Homo sapiens
10 AGPAT1 10554
Affinity Capture-MS Homo sapiens
11 Pten  
Affinity Capture-MS Mus musculus
12 NRSN1  
Affinity Capture-MS Homo sapiens
13 PRMT1 3276
Affinity Capture-MS Homo sapiens
14 MBD4  
Affinity Capture-MS Homo sapiens
15 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CCR1  
Affinity Capture-MS Homo sapiens
17 RAD51AP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 EGFR 1956
Affinity Capture-MS Homo sapiens
19 IGHG2 3501
Affinity Capture-MS Homo sapiens
20 HSPA5 3309
Affinity Capture-MS Homo sapiens
21 FHOD1 29109
Affinity Capture-MS Homo sapiens
22 OR2L13  
Affinity Capture-MS Homo sapiens
23 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
24 CERS3  
Affinity Capture-MS Homo sapiens
25 SLC6A1  
Affinity Capture-MS Homo sapiens
26 CHRDL2 25884
Affinity Capture-MS Homo sapiens
27 RNF115  
Affinity Capture-MS Homo sapiens
28 P2RX6  
Affinity Capture-MS Homo sapiens
29 S100A4 6275
Affinity Capture-MS Homo sapiens
30 KLK10 5655
Affinity Capture-MS Homo sapiens
31 SKA1  
Affinity Capture-MS Homo sapiens
32 MCM2 4171
Affinity Capture-MS Homo sapiens
33 PIGT 51604
Affinity Capture-MS Homo sapiens
34 PINK1  
Affinity Capture-MS Homo sapiens
35 CA8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 GOT1 2805
Affinity Capture-MS Homo sapiens
37 Cnot2  
Affinity Capture-MS Mus musculus
38 ALDH3A1 218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 OR2A4 79541
Affinity Capture-MS Homo sapiens
40 HCN1  
Affinity Capture-MS Homo sapiens
41 MATN2 4147
Affinity Capture-MS Homo sapiens
42 IGHV4-31 28396
Affinity Capture-MS Homo sapiens
43 BAG1 573
Affinity Capture-MS Homo sapiens
44 GJB5  
Affinity Capture-MS Homo sapiens
45 UBE2U  
Affinity Capture-MS Homo sapiens
46 GOPC 57120
Two-hybrid Homo sapiens
47 IGHG1 3500
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IGHG3 is involved
No pathways found





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