Gene description for GOPC
Gene name golgi-associated PDZ and coiled-coil motif containing
Gene symbol GOPC
Other names/aliases CAL
FIG
GOPC1
PIST
dJ94G16.2
Species Homo sapiens
 Database cross references - GOPC
ExoCarta ExoCarta_57120
Vesiclepedia VP_57120
Entrez Gene 57120
HGNC 17643
MIM 606845
UniProt Q9HD26  
 GOPC identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GOPC
Molecular Function
    frizzled binding GO:0005109 IEA
    protein C-terminus binding GO:0008022 IEA
    protein binding GO:0005515 IPI
    ion channel binding GO:0044325 IPI
    protein homodimerization activity GO:0042803 IEA
Biological Process
    protein homooligomerization GO:0051260 IPI
    Golgi to plasma membrane transport GO:0006893 NAS
    regulation of catalytic activity GO:0050790 IEA
    ER to Golgi vesicle-mediated transport GO:0006888 NAS
    spermatid nucleus differentiation GO:0007289 IEA
    cytoplasmic sequestering of CFTR protein GO:0043004 NAS
    small GTPase mediated signal transduction GO:0007264 TAS
    apical protein localization GO:0045176 NAS
    protein transport GO:0015031 IEA
Subcellular Localization
    trans-Golgi network transport vesicle GO:0030140 NAS
    protein complex GO:0043234 IDA
    cell junction GO:0030054 IEA
    plasma membrane GO:0005886 TAS
    Golgi apparatus GO:0005794 IDA
    postsynaptic density GO:0014069 IEA
    postsynaptic membrane GO:0045211 IEA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IDA
    dendrite GO:0030425 IEA
    Golgi-associated vesicle membrane GO:0030660 TAS
    lysosomal membrane GO:0005765 TAS
 Experiment description of studies that identified GOPC in exosomes
1
Experiment ID 489
ISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
ISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
ISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
ISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
ISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GOPC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VIM 7431
Two-hybrid Homo sapiens
2 STX6 10228
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
3 CDC42 998
Reconstituted Complex Homo sapiens
4 CFTR  
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 ACCN3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
6 BECN1 8678
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 GRID2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 FZD8 8325
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
9 CSPG5 10675
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
10 RHOQ 23433
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
11 GOPC 57120
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
12 CLCN3 1182
Invitro Homo sapiens
13 FZD5 7855
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GOPC is involved
PathwayEvidenceSource
RHO GTPases regulate CFTR trafficking TAS Reactome





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