Gene description for GOPC
Gene name golgi-associated PDZ and coiled-coil motif containing
Gene symbol GOPC
Other names/aliases CAL
FIG
GOPC1
PIST
dJ94G16.2
Species Homo sapiens
 Database cross references - GOPC
ExoCarta ExoCarta_57120
Vesiclepedia VP_57120
Entrez Gene 57120
HGNC 17643
MIM 606845
UniProt Q9HD26  
 GOPC identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GOPC
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    transmembrane transporter binding GO:0044325 IBA
    transmembrane transporter binding GO:0044325 IPI
    molecular sequestering activity GO:0140313 IMP
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 NAS
    Golgi to plasma membrane transport GO:0006893 NAS
    negative regulation of anion channel activity GO:0010360 IMP
    protein transport GO:0015031 IEA
    apical protein localization GO:0045176 NAS
    negative regulation of protein localization to cell surface GO:2000009 IBA
    negative regulation of protein localization to cell surface GO:2000009 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    postsynaptic density GO:0014069 IEA
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    trans-Golgi network transport vesicle GO:0030140 IBA
    trans-Golgi network transport vesicle GO:0030140 IDA
    trans-Golgi network transport vesicle GO:0030140 NAS
    dendrite GO:0030425 IEA
    Golgi-associated vesicle membrane GO:0030660 TAS
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified GOPC in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GOPC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBS 875
Co-fractionation Homo sapiens
2 TGOLN2 10618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MVP 9961
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 EIF4G3 8672
Co-fractionation Homo sapiens
5 CCDC151  
Affinity Capture-MS Homo sapiens
6 OCLN 100506658
Proximity Label-MS Homo sapiens
7 RHOQ 23433
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
8 KPNA1 3836
Two-hybrid Homo sapiens
9 CYYR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LAMP3  
Proximity Label-MS Homo sapiens
11 ATG9A 79065
Proximity Label-MS Homo sapiens
12 GJA1 2697
Proximity Label-MS Homo sapiens
13 PSMD11 5717
Co-fractionation Homo sapiens
14 TPD52L1 7164
Affinity Capture-MS Homo sapiens
15 NUP62 23636
Two-hybrid Homo sapiens
16 MARCH2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 LIMA1 51474
Affinity Capture-MS Homo sapiens
18 NUPL1 9818
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LDOC1L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CABLES1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 GJD3  
Proximity Label-MS Homo sapiens
22 LAMP2 3920
Proximity Label-MS Homo sapiens
23 ZSCAN1  
Two-hybrid Homo sapiens
24 DPYD 1806
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 SYDE2  
Affinity Capture-MS Homo sapiens
26 PARK7 11315
Two-hybrid Homo sapiens
27 CCDC102B  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
28 COX8A  
Proximity Label-MS Homo sapiens
29 CRAMP1L 57585
Affinity Capture-MS Homo sapiens
30 CD247 919
Affinity Capture-MS Homo sapiens
31 DNAJB6 10049
Proximity Label-MS Homo sapiens
32 CCDC43 124808
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ZNF488  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 NPM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 QPRT 23475
Affinity Capture-MS Homo sapiens
36 B3GAT1  
Proximity Label-MS Homo sapiens
37 TFAM 7019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 PPP2R5D 5528
Co-fractionation Homo sapiens
39 APBB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 GLIS2  
Affinity Capture-MS Homo sapiens
41 FAM174A 345757
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 RAB3B 5865
Proximity Label-MS Homo sapiens
43 FBXW7  
Affinity Capture-MS Homo sapiens
44 PROK1  
Affinity Capture-MS Homo sapiens
45 FBXO28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CLCN3 1182
Reconstituted Complex Homo sapiens
47 BRPF3  
Affinity Capture-MS Homo sapiens
48 PSMC2 5701
Co-fractionation Homo sapiens
49 FKBP11 51303
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 MANBAL 63905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 GOPC 57120
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
52 TCEB3B  
Affinity Capture-MS Homo sapiens
53 MUM1  
Two-hybrid Homo sapiens
54 ATG4D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RPL13AP17  
Two-hybrid Homo sapiens
56 METTL7A 25840
Proximity Label-MS Homo sapiens
57 RNF183  
Two-hybrid Homo sapiens
58 LCLAT1 253558
Two-hybrid Homo sapiens
59 TMEM136  
Affinity Capture-MS Homo sapiens
60 EBAG9 9166
Proximity Label-MS Homo sapiens
61 PSMC3 5702
Co-fractionation Homo sapiens
62 MARCKS 4082
Proximity Label-MS Homo sapiens
63 LAMTOR1 55004
Proximity Label-MS Homo sapiens
64 CLASP2 23122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 NUP155 9631
Proximity Label-MS Homo sapiens
66 VTN 7448
Two-hybrid Homo sapiens
67 TOLLIP 54472
Proximity Label-MS Homo sapiens
68 FAM96A  
Affinity Capture-MS Homo sapiens
69 RELA 5970
Two-hybrid Homo sapiens
70 UCN3  
Affinity Capture-MS Homo sapiens
71 BATF  
Two-hybrid Homo sapiens
72 RAB2A 5862
Proximity Label-MS Homo sapiens
73 PKN2 5586
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 CNTLN 54875
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 TRAM1 23471
Affinity Capture-MS Homo sapiens
76 HCK 3055
Two-hybrid Homo sapiens
77 CXADR 1525
Proximity Label-MS Homo sapiens
78 TBX22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 BTF3L4 91408
Co-fractionation Homo sapiens
80 IFNG 3458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 MCAM 4162
Proximity Label-MS Homo sapiens
82 SSTR5 6755
Reconstituted Complex Homo sapiens
83 CD300C  
Two-hybrid Homo sapiens
84 FAM9A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 DIRAS3  
Proximity Label-MS Homo sapiens
86 LRSAM1 90678
Co-fractionation Homo sapiens
87 AKIRIN1  
Two-hybrid Homo sapiens
88 CDKN3 1033
Affinity Capture-MS Homo sapiens
89 Grm5  
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
Reconstituted Complex Rattus norvegicus
90 ZNF564  
Two-hybrid Homo sapiens
91 MOV10 4343
Affinity Capture-RNA Homo sapiens
92 STX6 10228
Proximity Label-MS Homo sapiens
93 PML 5371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 ZNF581  
Two-hybrid Homo sapiens
95 FAM9B  
Two-hybrid Homo sapiens
96 GRID2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
97 ZBTB49 166793
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
98 CSPG5 10675
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
99 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
100 CERCAM 51148
Two-hybrid Homo sapiens
101 CLDN10  
Affinity Capture-MS Homo sapiens
102 FXYD1 5348
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 PID1 55022
Two-hybrid Homo sapiens
104 DLEU1  
Two-hybrid Homo sapiens
105 KIF1B 23095
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 GOLGA3 2802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 CXCR4 7852
Affinity Capture-MS Homo sapiens
108 HBS1L 10767
Affinity Capture-MS Homo sapiens
109 GRM5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 RAB5A 5868
Proximity Label-MS Homo sapiens
111 CENPF 1063
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 ZBTB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 RALBP1 10928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 IGHG3 3502
Two-hybrid Homo sapiens
115 CRYAB 1410
Affinity Capture-MS Homo sapiens
116 LAMP1 3916
Proximity Label-MS Homo sapiens
117 CCDC8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 CASC4 113201
Affinity Capture-MS Homo sapiens
119 DNAJC17  
Affinity Capture-MS Homo sapiens
120 CEBPG  
Affinity Capture-MS Homo sapiens
121 FAM90A1  
Two-hybrid Homo sapiens
122 METTL21B  
Affinity Capture-MS Homo sapiens
123 SPATA8  
Two-hybrid Homo sapiens
124 FOSL2  
Two-hybrid Homo sapiens
125 NXF1 10482
Affinity Capture-RNA Homo sapiens
126 JUN 3725
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
127 MRPL1  
Two-hybrid Homo sapiens
128 KCNE3  
Affinity Capture-MS Homo sapiens
129 ASIC3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
130 MORN4  
Two-hybrid Homo sapiens
131 SSNA1 8636
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 COPZ1 22818
Co-fractionation Homo sapiens
133 SLC25A18  
Two-hybrid Homo sapiens
134 FCHSD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 RAB9A 9367
Proximity Label-MS Homo sapiens
136 BAP1 8314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 PTPRB 5787
Proximity Label-MS Homo sapiens
138 MYOCD  
Two-hybrid Homo sapiens
139 JUNB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 ZNF587  
Two-hybrid Homo sapiens
141 EVI2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 STX4 6810
Proximity Label-MS Homo sapiens
143 SEMA4G  
Two-hybrid Homo sapiens
144 FFAR1  
Affinity Capture-MS Homo sapiens
145 CDKN2C  
Two-hybrid Homo sapiens
146 BATF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 DNAJC4  
Proximity Label-MS Homo sapiens
148 CDC25A  
Affinity Capture-MS Homo sapiens
149 SURF6  
Affinity Capture-MS Homo sapiens
150 SSTR3  
Affinity Capture-MS Homo sapiens
151 CCDC96  
Affinity Capture-MS Homo sapiens
152 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
153 RNF220  
Two-hybrid Homo sapiens
154 MYLK 4638
Two-hybrid Homo sapiens
155 TMEM9 252839
Affinity Capture-MS Homo sapiens
156 GRK6 2870
Affinity Capture-MS Homo sapiens
157 TGFBR2 7048
Two-hybrid Homo sapiens
158 MIS18BP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 CPSF6 11052
Affinity Capture-MS Homo sapiens
160 PCGF2 7703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 C5orf24 134553
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 ZNF264  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 CCDC102A 92922
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 PSMC4 5704
Co-fractionation Homo sapiens
165 ERLIN1 10613
Affinity Capture-MS Homo sapiens
166 DR1  
Co-fractionation Homo sapiens
167 NOL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 TRAT1 50852
Affinity Capture-MS Homo sapiens
169 CLDN3 1365
Affinity Capture-MS Homo sapiens
170 CDH23 64072
Affinity Capture-MS Homo sapiens
171 LY6G6F 259215
Affinity Capture-MS Homo sapiens
172 FYCO1 79443
Affinity Capture-MS Homo sapiens
173 MOG  
Affinity Capture-MS Homo sapiens
174 Stx6 60562
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
175 ELOVL5 60481
Proximity Label-MS Homo sapiens
176 STARD3 10948
Two-hybrid Homo sapiens
177 MLPH  
Affinity Capture-MS Homo sapiens
178 ERGIC2 51290
Proximity Label-MS Homo sapiens
179 DDIT3 1649
Affinity Capture-MS Homo sapiens
180 TCF4  
Affinity Capture-MS Homo sapiens
181 ADRA1D  
Affinity Capture-MS Homo sapiens
182 BECN1 8678
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
183 C17orf67  
Two-hybrid Homo sapiens
184 HSF1  
Co-fractionation Homo sapiens
185 RAB7A 7879
Proximity Label-MS Homo sapiens
186 NACC2  
Affinity Capture-MS Homo sapiens
187 RAB11A 8766
Proximity Label-MS Homo sapiens
188 CERS4  
Affinity Capture-MS Homo sapiens
189 EPHA2 1969
Proximity Label-MS Homo sapiens
190 CACNG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 RAB5C 5878
Proximity Label-MS Homo sapiens
192 C17orf80 55028
Proximity Label-MS Homo sapiens
193 CFTR 1080
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
194 VIM 7431
Two-hybrid Homo sapiens
195 CAV1 857
Proximity Label-MS Homo sapiens
196 C17orf59 54785
Proximity Label-MS Homo sapiens
197 ARIH1 25820
Co-fractionation Homo sapiens
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