Gene description for IFNG
Gene name	interferon, gamma
Gene symbol	IFNG
Other names/aliases	IFG IFI
Species	Homo sapiens
Database cross references - IFNG
ExoCarta	ExoCarta_3458
Entrez Gene	3458
HGNC	5438
MIM	147570
UniProt	P01579
IFNG identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for IFNG

Molecular Function     interferon-gamma receptor binding GO:0005133 IEA     cytokine activity GO:0005125 IBA Biological Process     defense response to bacterium GO:0042742 IEA     positive regulation of interleukin-23 production GO:0032747 IDA     CD8-positive, alpha-beta T cell differentiation involved in immune response GO:0002302 IEA     positive regulation of fructose 1,6-bisphosphate metabolic process GO:0060552 IDA     apoptotic process GO:0006915 IGI     positive regulation of nitric oxide biosynthetic process GO:0045429 IDA     positive regulation of interleukin-6 biosynthetic process GO:0045410 IEA     response to drug GO:0042493 IEA     cell surface receptor signaling pathway GO:0007166 TAS     positive regulation of MHC class II biosynthetic process GO:0045348 IEA     endoplasmic reticulum unfolded protein response GO:0030968 IEA     positive regulation of membrane protein ectodomain proteolysis GO:0051044 IDA     sensory perception of mechanical stimulus GO:0050954 IEA     movement of cell or subcellular component GO:0006928 TAS     protein import into nucleus, translocation GO:0000060 IDA     positive regulation of cell proliferation GO:0008284 ISS     positive regulation of interleukin-1 beta secretion GO:0050718 IEA     neutrophil chemotaxis GO:0030593 IEA     cellular response to lipopolysaccharide GO:0071222 IEA     cytokine-mediated signaling pathway GO:0019221 TAS     positive regulation of vitamin D biosynthetic process GO:0060557 IDA     positive regulation of epithelial cell migration GO:0010634 IDA     regulation of the force of heart contraction GO:0002026 IEA     positive regulation of interleukin-12 biosynthetic process GO:0045084 IEA     humoral immune response GO:0006959 IBA     response to virus GO:0009615 IDA     defense response to virus GO:0051607 IEA     positive regulation of interleukin-12 production GO:0032735 IDA     negative regulation of growth of symbiont in host GO:0044130 IEA     extrinsic apoptotic signaling pathway GO:0097191 IDA     antigen processing and presentation GO:0019882 IEA     positive regulation of tumor necrosis factor production GO:0032760 IEA     regulation of neuronal action potential GO:0098908 IEA     positive regulation of osteoclast differentiation GO:0045672 IDA     positive regulation of synaptic transmission, cholinergic GO:0032224 IEA     positive regulation of chemokine biosynthetic process GO:0045080 IEA     positive regulation of killing of cells of other organism GO:0051712 IDA     negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0072308 IEA     interferon-gamma-mediated signaling pathway GO:0060333 TAS     regulation of insulin secretion GO:0050796 IDA     defense response to protozoan GO:0042832 IEA     positive regulation of neuron differentiation GO:0045666 IEA     regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS     positive regulation of calcidiol 1-monooxygenase activity GO:0060559 IDA     negative regulation of myelination GO:0031642 IEA     positive regulation of isotype switching to IgG isotypes GO:0048304 IEA     positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 IDA     negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340 IEA     negative regulation of smooth muscle cell proliferation GO:0048662 IDA     regulation of hepatocyte proliferation GO:2000345 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 NAS     positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity GO:0060550 IDA     negative regulation of interleukin-17 production GO:0032700 IDA     negative regulation of epithelial cell differentiation GO:0030857 ISS     adaptive immune response GO:0002250 IBA     neutrophil apoptotic process GO:0001781 IEA     positive regulation of mesenchymal cell proliferation GO:0002053 IEA     positive regulation of tumor necrosis factor (ligand) superfamily member 11 production GO:2000309 IDA     positive regulation of T cell proliferation GO:0042102 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS     cell cycle arrest GO:0007050 IDA     positive regulation of smooth muscle cell apoptotic process GO:0034393 IDA     cellular response to interleukin-18 GO:0071351 IEA Subcellular Localization     extracellular space GO:0005615 IBA     external side of plasma membrane GO:0009897 IEA     intracellular GO:0005622 IDA     extracellular region GO:0005576 TAS