Gene description for TRIM38
Gene name tripartite motif containing 38
Gene symbol TRIM38
Other names/aliases RNF15
RORET
Species Homo sapiens
 Database cross references - TRIM38
ExoCarta ExoCarta_10475
Entrez Gene 10475
HGNC 10059
UniProt O00635  
 TRIM38 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TRIM38
Molecular Function
    signal transducer activity GO:0004871 IMP
    ligase activity GO:0016874 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    protein K48-linked ubiquitination GO:0070936 IEA
    positive regulation of viral genome replication GO:0045070 IEA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    positive regulation of viral entry into host cell GO:0046598 IDA
    regulation of interferon-beta production GO:0032648 IEA
    cytokine-mediated signaling pathway GO:0019221 TAS
    negative regulation of defense response to virus GO:0050687 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    cellular_component GO:0005575 ND
 Experiment description of studies that identified TRIM38 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRIM38
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRIM38 is involved
PathwayEvidenceSource
Interferon gamma signaling TAS Reactome





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