Gene description for TSPYL4
Gene name TSPY-like 4
Gene symbol TSPYL4
Other names/aliases dJ486I3.2
Species Homo sapiens
 Database cross references - TSPYL4
ExoCarta ExoCarta_23270
Vesiclepedia VP_23270
Entrez Gene 23270
HGNC 21559
UniProt Q9UJ04  
 TSPYL4 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for TSPYL4
Molecular Function
    chromatin binding GO:0003682 IBA
    protein binding GO:0005515 IPI
    histone binding GO:0042393 IBA
Biological Process
    nucleosome assembly GO:0006334 IEA
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified TSPYL4 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TSPYL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CEP57  
Two-hybrid Homo sapiens
2 NAP1L4 4676
Affinity Capture-MS Homo sapiens
3 TRIM38 10475
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 TSPY2  
Affinity Capture-MS Homo sapiens
5 TFIP11  
Two-hybrid Homo sapiens
6 POLR2J3  
Affinity Capture-MS Homo sapiens
7 TH  
Two-hybrid Homo sapiens
8 NINL  
Two-hybrid Homo sapiens
9 NAP1L2  
Affinity Capture-MS Homo sapiens
10 C15orf59  
Affinity Capture-MS Homo sapiens
11 GOLGA6L9  
Two-hybrid Homo sapiens
12 NF2 4771
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DFFA 1676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 S100A2 6273
Affinity Capture-MS Homo sapiens
15 NAP1L3  
Two-hybrid Homo sapiens
16 P4HA2 8974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 H1F0 3005
Affinity Capture-MS Homo sapiens
18 TSPYL1 7259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DCAF8L2  
Affinity Capture-MS Homo sapiens
20 BOLA2 552900
Affinity Capture-MS Homo sapiens
21 CMBL 134147
Affinity Capture-MS Homo sapiens
22 PNMA1 9240
Two-hybrid Homo sapiens
23 SULF2 55959
Affinity Capture-MS Homo sapiens
24 IFT74 80173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 KLHDC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CCDC85B  
Two-hybrid Homo sapiens
27 NFKBIL1  
Affinity Capture-MS Homo sapiens
28 CDK5RAP3 80279
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 ZNF655  
Two-hybrid Homo sapiens
30 MIPOL1  
Affinity Capture-MS Homo sapiens
31 MAGEA4 4103
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
32 AKAP1 8165
Affinity Capture-MS Homo sapiens
33 NAP1L5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 PIPSL 266971
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TSPYL4 is involved
No pathways found





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