Gene description for SULF2
Gene name sulfatase 2
Gene symbol SULF2
Other names/aliases HSULF-2
Species Homo sapiens
 Database cross references - SULF2
ExoCarta ExoCarta_55959
Entrez Gene 55959
HGNC 20392
MIM 610013
UniProt Q8IWU5  
 SULF2 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for SULF2
Molecular Function
    arylsulfatase activity GO:0004065 IMP
    calcium ion binding GO:0005509 IEA
    N-acetylglucosamine-6-sulfatase activity GO:0008449 IMP
Biological Process
    positive regulation of vascular endothelial growth factor production GO:0010575 ISS
    bone development GO:0060348 ISS
    heparan sulfate proteoglycan metabolic process GO:0030201 NAS
    innervation GO:0060384 ISS
    glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 ISS
    negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 ISS
    esophagus smooth muscle contraction GO:0014846 ISS
    kidney development GO:0001822 ISS
    glomerular filtration GO:0003094 ISS
    cartilage development GO:0051216 ISS
    embryonic skeletal system development GO:0048706 ISS
    chondrocyte development GO:0002063 ISS
    positive regulation of Wnt signaling pathway GO:0030177 IDA
    glomerular basement membrane development GO:0032836 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    Golgi stack GO:0005795 IEA
    cell surface GO:0009986 IDA
    plasma membrane GO:0005886 ISS
    extracellular space GO:0005615 NAS
 Experiment description of studies that identified SULF2 in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SULF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SULF2 is involved
No pathways found





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