Gene description for SUMF1
Gene name sulfatase modifying factor 1
Gene symbol SUMF1
Other names/aliases AAPA3037
FGE
UNQ3037
Species Homo sapiens
 Database cross references - SUMF1
ExoCarta ExoCarta_285362
Vesiclepedia VP_285362
Entrez Gene 285362
HGNC 20376
MIM 607939
UniProt Q8NBK3  
 SUMF1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SUMF1
Molecular Function
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 TAS
    identical protein binding GO:0042802 IPI
    formylglycine-generating oxidase activity GO:0120147 IBA
    formylglycine-generating oxidase activity GO:0120147 IDA
    cupric ion binding GO:1903135 IDA
Biological Process
    protein oxidation GO:0018158 IDA
    post-translational protein modification GO:0043687 IDA
    post-translational protein modification GO:0043687 TAS
    glycosphingolipid catabolic process GO:0046479 TAS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    membrane GO:0016020 IEA
 Experiment description of studies that identified SUMF1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SUMF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 ARSA 410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ARSE 415
Affinity Capture-MS Homo sapiens
4 BTNL2  
Affinity Capture-MS Homo sapiens
5 NAAA  
Affinity Capture-MS Homo sapiens
6 KLK15  
Affinity Capture-MS Homo sapiens
7 ECEL1  
Affinity Capture-MS Homo sapiens
8 B3GNT3 10331
Affinity Capture-MS Homo sapiens
9 SGSH 6448
Affinity Capture-MS Homo sapiens
10 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PTGES2 80142
Affinity Capture-MS Homo sapiens
12 CTRC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 COL4A6 1288
Co-fractionation Homo sapiens
14 PRSS2 5645
Affinity Capture-MS Homo sapiens
15 PRG2  
Affinity Capture-MS Homo sapiens
16 PI15  
Affinity Capture-MS Homo sapiens
17 STS 412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 FUCA1 2517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 LYPD4  
Affinity Capture-MS Homo sapiens
20 NCR3  
Affinity Capture-MS Homo sapiens
21 IL5RA  
Affinity Capture-MS Homo sapiens
22 KLK2  
Affinity Capture-MS Homo sapiens
23 KLK1 3816
Affinity Capture-MS Homo sapiens
24 ERP44 23071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 OMD 4958
Affinity Capture-MS Homo sapiens
26 TNFSF13 8741
Affinity Capture-MS Homo sapiens
27 IDS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SULF2 55959
Affinity Capture-MS Homo sapiens
29 PNLIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CRLF1 9244
Affinity Capture-MS Homo sapiens
31 FBXO2 26232
Affinity Capture-MS Homo sapiens
32 GGH 8836
Affinity Capture-MS Homo sapiens
33 GNS 2799
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 STIM2 57620
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 CST11  
Affinity Capture-MS Homo sapiens
36 EDN3  
Affinity Capture-MS Homo sapiens
37 NXPH3  
Affinity Capture-MS Homo sapiens
38 GALNS 2588
Affinity Capture-MS Homo sapiens
39 ARSG 22901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ARSK  
Affinity Capture-MS Homo sapiens
41 IFNA21  
Affinity Capture-MS Homo sapiens
42 ARSF 416
Affinity Capture-MS Homo sapiens
43 SUN2 25777
Affinity Capture-MS Homo sapiens
44 MSRA 4482
Affinity Capture-MS Homo sapiens
45 LIPG 9388
Affinity Capture-MS Homo sapiens
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