Gene description for STIM2
Gene name stromal interaction molecule 2
Gene symbol STIM2
Other names/aliases -
Species Homo sapiens
 Database cross references - STIM2
ExoCarta ExoCarta_57620
Vesiclepedia VP_57620
Entrez Gene 57620
HGNC 19205
MIM 610841
UniProt Q9P246  
 STIM2 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for STIM2
Molecular Function
    calcium channel regulator activity GO:0005246 IBA
    calcium channel regulator activity GO:0005246 IMP
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    store-operated calcium channel activity GO:0015279 IDA
Biological Process
    store-operated calcium entry GO:0002115 IBA
    intracellular calcium ion homeostasis GO:0006874 IBA
    intracellular calcium ion homeostasis GO:0006874 IMP
    activation of store-operated calcium channel activity GO:0032237 IDA
    activation of store-operated calcium channel activity GO:0032237 IMP
    positive regulation of calcium ion transport GO:0051928 IDA
    positive regulation of calcium ion transport GO:0051928 IMP
    calcium ion transmembrane transport GO:0070588 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified STIM2 in exosomes
1
Experiment ID 494
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for STIM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMOX1 3162
Affinity Capture-MS Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 DPH2 1802
Affinity Capture-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 GJA1 2697
Proximity Label-MS Homo sapiens
6 YWHAE 7531
Affinity Capture-MS Homo sapiens
7 ECEL1  
Affinity Capture-MS Homo sapiens
8 GJD3  
Proximity Label-MS Homo sapiens
9 DNAJC25 548645
Proximity Label-MS Homo sapiens
10 CALM1 801
Reconstituted Complex Homo sapiens
11 PTPN1 5770
Proximity Label-MS Homo sapiens
12 PRPF40A 55660
Two-hybrid Homo sapiens
13 STX4 6810
Proximity Label-MS Homo sapiens
14 B3GAT1  
Proximity Label-MS Homo sapiens
15 RAB3B 5865
Proximity Label-MS Homo sapiens
16 HEXB 3074
Co-fractionation Homo sapiens
17 YWHAG 7532
Affinity Capture-MS Homo sapiens
18 SSR1 6745
Proximity Label-MS Homo sapiens
19 PIGH  
Affinity Capture-MS Homo sapiens
20 STX6 10228
Proximity Label-MS Homo sapiens
21 SLC25A46 91137
Proximity Label-MS Homo sapiens
22 NAGK 55577
Affinity Capture-MS Homo sapiens
23 RAB35 11021
Proximity Label-MS Homo sapiens
24 TMEM106A  
Affinity Capture-MS Homo sapiens
25 DPH1  
Affinity Capture-MS Homo sapiens
26 MARCKS 4082
Proximity Label-MS Homo sapiens
27 KIF14 9928
Affinity Capture-MS Homo sapiens
28 YWHAB 7529
Affinity Capture-MS Homo sapiens
29 NUP155 9631
Proximity Label-MS Homo sapiens
30 KIAA1715 80856
Proximity Label-MS Homo sapiens
31 PXMP2  
Proximity Label-MS Homo sapiens
32 BAG5 9529
Affinity Capture-MS Homo sapiens
33 PANX1 24145
Proximity Label-MS Homo sapiens
34 EMD 2010
Proximity Label-MS Homo sapiens
35 CXADR 1525
Proximity Label-MS Homo sapiens
36 PRKAG1 5571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 MCAM 4162
Proximity Label-MS Homo sapiens
38 CCDC107  
Affinity Capture-MS Homo sapiens
39 DTX2 113878
Proximity Label-MS Homo sapiens
40 DNAJC16  
Proximity Label-MS Homo sapiens
41 RPN1 6184
Proximity Label-MS Homo sapiens
42 SUMF1 285362
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PRKAB1 5564
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ELOVL5 60481
Proximity Label-MS Homo sapiens
45 SEC61B 10952
Proximity Label-MS Homo sapiens
46 RMDN3 55177
Proximity Label-MS Homo sapiens
47 BRINP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 REEP5 7905
Proximity Label-MS Homo sapiens
49 SEC63 11231
Proximity Label-MS Homo sapiens
50 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
51 RPN2 6185
Proximity Label-MS Homo sapiens
52 LRRC59 55379
Proximity Label-MS Homo sapiens
53 LMNB1 4001
Proximity Label-MS Homo sapiens
54 ZDHHC12  
Affinity Capture-MS Homo sapiens
55 HMOX2 3163
Affinity Capture-MS Homo sapiens
56 PRKAA2 5563
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 BCAP31 10134
Proximity Label-MS Homo sapiens
58 HSD3B7 80270
Proximity Label-MS Homo sapiens
59 YWHAZ 7534
Affinity Capture-MS Homo sapiens
60 STIM1 6786
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 FKBP8 23770
Proximity Label-MS Homo sapiens
62 HEXA 3073
Co-fractionation Homo sapiens
63 MAPRE3  
Proximity Label-MS Homo sapiens
64 ATP2A1 487
Proximity Label-MS Homo sapiens
65 RAB9A 9367
Proximity Label-MS Homo sapiens
66 MSRB3 253827
Affinity Capture-MS Homo sapiens
67 RHOB 388
Proximity Label-MS Homo sapiens
68 CYP2C9  
Proximity Label-MS Homo sapiens
69 PRKAB2 5565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 NADK2 133686
Affinity Capture-MS Homo sapiens
71 PRKAA1 5562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CRLF2 64109
Affinity Capture-MS Homo sapiens
73 RNF43  
Proximity Label-MS Homo sapiens
74 CD1A 909
Affinity Capture-MS Homo sapiens
75 LMAN1 3998
Proximity Label-MS Homo sapiens
76 PRKAG2 51422
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 ITPR3 3710
Affinity Capture-MS Homo sapiens
78 TMLHE 55217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 SFTPC  
Affinity Capture-MS Homo sapiens
80 ERGIC2 51290
Proximity Label-MS Homo sapiens
81 PARS2 25973
Affinity Capture-MS Homo sapiens
82 SEC62 7095
Proximity Label-MS Homo sapiens
83 RAB7A 7879
Proximity Label-MS Homo sapiens
84 LIPA 3988
Affinity Capture-MS Homo sapiens
85 HNRNPF 3185
Cross-Linking-MS (XL-MS) Homo sapiens
86 EPHA2 1969
Proximity Label-MS Homo sapiens
87 CISD2 493856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 DNAJC1 64215
Proximity Label-MS Homo sapiens
89 KRAS 3845
Proximity Label-MS Homo sapiens
90 CKAP4 10970
Proximity Label-MS Homo sapiens
91 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which STIM2 is involved
No pathways found





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