Gene description for HMOX2
Gene name heme oxygenase 2
Gene symbol HMOX2
Other names/aliases HO-2
Species Homo sapiens
 Database cross references - HMOX2
ExoCarta ExoCarta_3163
Entrez Gene 3163
HGNC 5014
MIM 141251
UniProt P30519  
 HMOX2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for HMOX2
Molecular Function
    heme oxygenase (decyclizing) activity GO:0004392 IDA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
Biological Process
    porphyrin-containing compound metabolic process GO:0006778 TAS
    cellular iron ion homeostasis GO:0006879 TAS
    small molecule metabolic process GO:0044281 TAS
    heme catabolic process GO:0042167 TAS
    heme oxidation GO:0006788 IEA
    transmembrane transport GO:0055085 TAS
    response to hypoxia GO:0001666 IDA
Subcellular Localization
    membrane GO:0016020 IDA
    plasma membrane GO:0005886 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified HMOX2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HMOX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 HAP1  
Two-hybrid Homo sapiens
3 GPRASP1  
Two-hybrid Homo sapiens
4 MED31  
Two-hybrid Homo sapiens
5 GIT1 28964
Two-hybrid Homo sapiens
6 EEF1G 1937
Two-hybrid Homo sapiens
7 KIAA1377  
Two-hybrid Homo sapiens
8 COPS6 10980
Two-hybrid Homo sapiens
9 SETDB1  
Two-hybrid Homo sapiens
10 RIF1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HMOX2 is involved
PathwayEvidenceSource
Heme degradation TAS Reactome
Iron uptake and transport TAS Reactome





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