Gene description for NDUFV2
Gene name NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
Gene symbol NDUFV2
Other names/aliases CI-24k
Species Homo sapiens
 Database cross references - NDUFV2
ExoCarta ExoCarta_4729
Vesiclepedia VP_4729
Entrez Gene 4729
HGNC 7717
MIM 600532
UniProt P19404  
 NDUFV2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NDUFV2
Molecular Function
    NADH dehydrogenase activity GO:0003954 IBA
    protein binding GO:0005515 IPI
    NADH dehydrogenase (ubiquinone) activity GO:0008137 IDA
    NADH dehydrogenase (ubiquinone) activity GO:0008137 IMP
    NADH dehydrogenase (ubiquinone) activity GO:0008137 NAS
    electron transfer activity GO:0009055 NAS
    metal ion binding GO:0046872 IEA
    2 iron, 2 sulfur cluster binding GO:0051537 IEA
Biological Process
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 IBA
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 IDA
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 IMP
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
    nervous system development GO:0007399 IMP
    aerobic respiration GO:0009060 NAS
    proton motive force-driven mitochondrial ATP synthesis GO:0042776 NAS
    cardiac muscle tissue development GO:0048738 IMP
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    respiratory chain complex I GO:0045271 IBA
    respiratory chain complex I GO:0045271 IDA
    respiratory chain complex I GO:0045271 IMP
    respiratory chain complex I GO:0045271 NAS
 Experiment description of studies that identified NDUFV2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NDUFV2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP6V1B2 526
Co-fractionation Homo sapiens
2 SLIRP 81892
Proximity Label-MS Homo sapiens
3 C6orf203  
Proximity Label-MS Homo sapiens
4 NPC2 10577
Co-fractionation Homo sapiens
5 NDUFB8 4714
Affinity Capture-MS Homo sapiens
6 POR 5447
Co-fractionation Homo sapiens
7 CBX1 10951
Affinity Capture-MS Homo sapiens
8 DNAJA3 9093
Proximity Label-MS Homo sapiens
9 VAPA 9218
Affinity Capture-MS Homo sapiens
10 HINT2 84681
Proximity Label-MS Homo sapiens
11 TRUB2  
Proximity Label-MS Homo sapiens
12 MTG2  
Proximity Label-MS Homo sapiens
13 NGRN  
Proximity Label-MS Homo sapiens
14 CHCHD1  
Proximity Label-MS Homo sapiens
15 NDUFS7 374291
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
16 NDUFA4 4697
Affinity Capture-MS Homo sapiens
17 ASPH 444
Co-fractionation Homo sapiens
18 STK3 6788
Affinity Capture-MS Homo sapiens
19 DNAJC15  
Proximity Label-MS Homo sapiens
20 NDUFS2 4720
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 GFM2 84340
Proximity Label-MS Homo sapiens
22 CCDC90B  
Proximity Label-MS Homo sapiens
23 LRPPRC 10128
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
24 SEPT9 10801
Co-fractionation Homo sapiens
25 ND4 4538
Affinity Capture-MS Homo sapiens
26 NDUFS3 4722
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CRYZ 1429
Proximity Label-MS Homo sapiens
28 TFAM 7019
Proximity Label-MS Homo sapiens
29 PMPCA 23203
Proximity Label-MS Homo sapiens
30 SDHB 6390
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
31 NDUFA7 4701
Affinity Capture-MS Homo sapiens
32 C8orf82  
Proximity Label-MS Homo sapiens
33 ARMCX3 51566
Co-fractionation Homo sapiens
34 MRPS26 64949
Proximity Label-MS Homo sapiens
35 SURF1  
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
36 EXD2  
Proximity Label-MS Homo sapiens
37 LACTB 114294
Co-fractionation Homo sapiens
38 VDAC1 7416
Affinity Capture-MS Homo sapiens
39 NDUFV1 4723
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
40 NDUFV3 4731
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
41 CANX 821
Co-fractionation Homo sapiens
42 MECP2 4204
Affinity Capture-MS Homo sapiens
43 PMPCB 9512
Proximity Label-MS Homo sapiens
44 NDUFA11 126328
Affinity Capture-MS Homo sapiens
45 FASTKD2  
Proximity Label-MS Homo sapiens
46 NDUFA6  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
47 NDUFS1 4719
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
48 PCYOX1 51449
Co-fractionation Homo sapiens
49 NDUFS5 4725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SLC25A3 5250
Co-fractionation Homo sapiens
51 KIF14 9928
Affinity Capture-MS Homo sapiens
52 NOTCH2 4853
Co-fractionation Homo sapiens
53 NDUFA13 51079
Affinity Capture-MS Homo sapiens
54 MDH2 4191
Proximity Label-MS Homo sapiens
55 NNT 23530
Co-fractionation Homo sapiens
56 SDHA 6389
Co-fractionation Homo sapiens
57 P4HA1 5033
Co-fractionation Homo sapiens
58 NDUFS4 4724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 COX15 1355
Proximity Label-MS Homo sapiens
60 FASTKD5  
Proximity Label-MS Homo sapiens
61 NDUFB7 4713
Affinity Capture-MS Homo sapiens
62 ND5 4540
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 NDUFA8 4702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 TUFM 7284
Proximity Label-MS Homo sapiens
65 HSCB 150274
Proximity Label-MS Homo sapiens
66 SP110  
Two-hybrid Homo sapiens
67 VCP 7415
Co-fractionation Homo sapiens
68 ND1  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
69 HMOX2 3163
Co-fractionation Homo sapiens
70 FAM185A  
Affinity Capture-MS Homo sapiens
71 TPI1 7167
Co-fractionation Homo sapiens
72 CCDC109B 55013
Proximity Label-MS Homo sapiens
73 SYNCRIP 10492
Co-fractionation Homo sapiens
74 NDUFA2 4695
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
75 CYC1 1537
Co-fractionation Homo sapiens
76 UQCRC1 7384
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
77 MCU 90550
Proximity Label-MS Homo sapiens
78 MTFMT  
Proximity Label-MS Homo sapiens
79 MRPL11 65003
Proximity Label-MS Homo sapiens
80 MTRF1L  
Proximity Label-MS Homo sapiens
81 UQCRH 7388
Co-fractionation Homo sapiens
82 NDUFB9 4715
Affinity Capture-MS Homo sapiens
83 TMEM70  
Proximity Label-MS Homo sapiens
84 COX4I1 1327
Proximity Label-MS Homo sapiens
85 NDUFB5 4711
Affinity Capture-MS Homo sapiens
86 Rab5c 19345
Affinity Capture-MS Mus musculus
87 C15orf48  
Affinity Capture-MS Homo sapiens
88 Hsf1  
Affinity Capture-MS Mus musculus
89 OTC 5009
Proximity Label-MS Homo sapiens
90 CRMP1 1400
Two-hybrid Homo sapiens
91 TMED9 54732
Co-fractionation Homo sapiens
92 MRRF  
Proximity Label-MS Homo sapiens
93 MRPS12  
Proximity Label-MS Homo sapiens
94 MTIF2 4528
Proximity Label-MS Homo sapiens
95 NDUFB10 4716
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
96 PITRM1 10531
Co-fractionation Homo sapiens
97 LRRC59 55379
Co-fractionation Homo sapiens
98 NDUFA9 4704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 CLPP 8192
Proximity Label-MS Homo sapiens
100 MTIF3  
Proximity Label-MS Homo sapiens
101 NPTN 27020
Co-fractionation Homo sapiens
102 RASSF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 GOLT1B 51026
Affinity Capture-MS Homo sapiens
104 Rmdn3  
Affinity Capture-MS Mus musculus
105 TJP1 7082
Co-fractionation Homo sapiens
106 FOXG1  
Affinity Capture-MS Homo sapiens
107 NR3C1 2908
Proximity Label-MS Homo sapiens
108 COX6A1  
Co-fractionation Homo sapiens
109 DHX30 22907
Proximity Label-MS Homo sapiens
110 CORO1C 23603
Co-fractionation Homo sapiens
111 FN1 2335
Affinity Capture-MS Homo sapiens
112 C17orf80 55028
Proximity Label-MS Homo sapiens
113 C12orf65  
Proximity Label-MS Homo sapiens
114 TACO1  
Proximity Label-MS Homo sapiens
115 RPUSD4 84881
Proximity Label-MS Homo sapiens
116 NDUFB3 4709
Affinity Capture-MS Homo sapiens
117 EMC2 9694
Co-fractionation Homo sapiens
118 KAT5  
Two-hybrid Homo sapiens
119 ACAD9 28976
Proximity Label-MS Homo sapiens
120 VWA8 23078
Proximity Label-MS Homo sapiens
121 NDUFA3  
Affinity Capture-MS Homo sapiens
122 NDUFA10 4705
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
123 STK4 6789
Affinity Capture-MS Homo sapiens
124 COX2 4513
Co-fractionation Homo sapiens
125 NDUFA1 4694
Affinity Capture-MS Homo sapiens
126 HSPA9 3313
Proximity Label-MS Homo sapiens
127 PUS1 80324
Affinity Capture-MS Homo sapiens
128 NDUFC2 4718
Affinity Capture-MS Homo sapiens
129 METTL15  
Proximity Label-MS Homo sapiens
130 MCUR1 63933
Proximity Label-MS Homo sapiens
131 MTRF1  
Proximity Label-MS Homo sapiens
132 MTERF3  
Proximity Label-MS Homo sapiens
133 DNAJC28  
Proximity Label-MS Homo sapiens
134 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
135 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
136 TSFM 10102
Proximity Label-MS Homo sapiens
137 AUH 549
Proximity Label-MS Homo sapiens
138 TBRG4 9238
Proximity Label-MS Homo sapiens
139 DNAJC19 131118
Proximity Label-MS Homo sapiens
140 NDUFAF2  
Affinity Capture-MS Homo sapiens
141 ICT1 3396
Proximity Label-MS Homo sapiens
142 DNAJC30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 LONP1 9361
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
144 FOXB1  
Affinity Capture-MS Homo sapiens
145 BCKDHA 593
Co-fractionation Homo sapiens
146 CCNC  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
147 NDUFA12 55967
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 PDHB 5162
Co-fractionation Homo sapiens
149 NDUFB1 4707
Affinity Capture-MS Homo sapiens
150 C21orf33  
Proximity Label-MS Homo sapiens
151 SVIL 6840
Co-fractionation Homo sapiens
152 SSBP1 6742
Proximity Label-MS Homo sapiens
153 MMGT1 93380
Affinity Capture-MS Homo sapiens
154 SUCLG2 8801
Co-fractionation Homo sapiens
155 FASTKD3  
Proximity Label-MS Homo sapiens
156 NDUFS8 4728
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
157 GFM1 85476
Proximity Label-MS Homo sapiens
158 AARS2  
Proximity Label-MS Homo sapiens
159 TEFM  
Proximity Label-MS Homo sapiens
160 RAB7A 7879
Affinity Capture-MS Homo sapiens
161 RPUSD3  
Proximity Label-MS Homo sapiens
162 GRSF1 2926
Proximity Label-MS Homo sapiens
163 C1QBP 708
Proximity Label-MS Homo sapiens
164 NDUFB6 4712
Affinity Capture-MS Homo sapiens
165 NDUFB11 54539
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 GOLM1 51280
Two-hybrid Homo sapiens
167 METTL17  
Proximity Label-MS Homo sapiens
168 NVL  
Affinity Capture-MS Homo sapiens
169 NDUFS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 DDX28  
Proximity Label-MS Homo sapiens
171 NDUFB4 4710
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
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