Gene description for MMGT1
Gene name membrane magnesium transporter 1
Gene symbol MMGT1
Other names/aliases EMC5
TMEM32
Species Homo sapiens
 Database cross references - MMGT1
ExoCarta ExoCarta_93380
Entrez Gene 93380
HGNC 28100
UniProt Q8N4V1  
 MMGT1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MMGT1
Molecular Function
    magnesium ion transmembrane transporter activity GO:0015095 ISS
Biological Process
    transmembrane transport GO:0055085 TAS
    magnesium ion transport GO:0015693 ISS
Subcellular Localization
    integral component of membrane GO:0016021 IDA
    Golgi membrane GO:0000139 IEA
    Golgi apparatus GO:0005794 ISS
    early endosome membrane GO:0031901 IEA
    early endosome GO:0005769 ISS
    ER membrane protein complex GO:0072546 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified MMGT1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MMGT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MMGT1 is involved
PathwayEvidenceSource
Miscellaneous transport and binding events TAS Reactome





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