Gene description for Tmed2
Gene name transmembrane emp24 domain trafficking protein 2
Gene symbol Tmed2
Other names/aliases 1110032D12Rik
1810020N21Rik
Rnp24
Sid394
p24beta1
Species Mus musculus
 Database cross references - Tmed2
ExoCarta ExoCarta_56334
Entrez Gene 56334
UniProt Q9R0Q3  
 Tmed2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tmed2
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    somite rostral/caudal axis specification GO:0032525 IMP
    embryonic placenta development GO:0001892 IMP
    intracellular protein transport GO:0006886 ISO
    protein targeting to plasma membrane GO:0072661 ISO
    somitogenesis GO:0001756 IMP
    heart looping GO:0001947 IMP
    negative regulation of GTPase activity GO:0034260 ISO
    post-anal tail morphogenesis GO:0036342 IMP
    multicellular organism growth GO:0035264 IMP
    Golgi organization GO:0007030 ISO
    positive regulation of gene expression GO:0010628 IMP
    neural tube closure GO:0001843 IMP
    in utero embryonic development GO:0001701 IMP
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 ISO
    COPI-coated vesicle GO:0030137 ISO
    integral component of membrane GO:0016021 ISO
    Golgi apparatus GO:0005794 ISO
    zymogen granule membrane GO:0042589 ISO
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO
 Experiment description of studies that identified Tmed2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tmed2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmed2 is involved
PathwayEvidenceSource
Pre-NOTCH Processing in Golgi IEA Reactome





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