Gene description for GOSR1
Gene name golgi SNAP receptor complex member 1
Gene symbol GOSR1
Other names/aliases GOLIM2
GOS-28
GOS28
GOS28/P28
GS28
P28
Species Homo sapiens
 Database cross references - GOSR1
ExoCarta ExoCarta_9527
Vesiclepedia VP_9527
Entrez Gene 9527
HGNC 4430
MIM 604026
UniProt O95249  
 GOSR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for GOSR1
Molecular Function
    SNAP receptor activity GO:0005484 IBA
    SNAP receptor activity GO:0005484 IDA
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    intra-Golgi vesicle-mediated transport GO:0006891 TAS
    vesicle fusion GO:0006906 IBA
    protein transport GO:0015031 IEA
    retrograde transport, endosome to Golgi GO:0042147 IDA
    inter-Golgi cisterna vesicle-mediated transport GO:0048219 IBA
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IDA
    Golgi medial cisterna GO:0005797 IBA
    cis-Golgi network GO:0005801 IEA
    cytosol GO:0005829 IEA
    membrane GO:0016020 HDA
    transport vesicle GO:0030133 TAS
    SNARE complex GO:0031201 IBA
    SNARE complex GO:0031201 TAS
 Experiment description of studies that identified GOSR1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GOSR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATAD1 84896
Affinity Capture-Western Homo sapiens
2 SEC22B 9554
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 Tmed2 56334
Affinity Capture-MS Mus musculus
5 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PCDHGA6 56109
Affinity Capture-MS Homo sapiens
7 VAPA 9218
Affinity Capture-MS Homo sapiens
8 NAPA 8775
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SRPRB 58477
Affinity Capture-MS Homo sapiens
10 DYNC1I2 1781
Proximity Label-MS Homo sapiens
11 BSCL2  
Affinity Capture-MS Homo sapiens
12 NBAS 51594
Affinity Capture-MS Homo sapiens
13 LAMP2 3920
Proximity Label-MS Homo sapiens
14 GOSR2 9570
Affinity Capture-MS Homo sapiens
15 PTPN1 5770
Affinity Capture-MS Homo sapiens
16 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 APP 351
Reconstituted Complex Homo sapiens
18 TMEM200A 114801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 APEX1 328
Affinity Capture-RNA Homo sapiens
20 B3GAT1  
Proximity Label-MS Homo sapiens
21 USO1 8615
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
22 CTLA4  
Affinity Capture-MS Homo sapiens
23 STX8 9482
Affinity Capture-MS Homo sapiens
24 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RER1 11079
Affinity Capture-MS Homo sapiens
26 RHOA 387
Synthetic Lethality Homo sapiens
27 TTYH1  
Affinity Capture-MS Homo sapiens
28 TMEM150A  
Affinity Capture-MS Homo sapiens
29 EDAR  
Affinity Capture-MS Homo sapiens
30 BET1 10282
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
31 EBAG9 9166
Proximity Label-MS Homo sapiens
32 TMEM59 9528
Affinity Capture-MS Homo sapiens
33 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
34 LAMTOR1 55004
Proximity Label-MS Homo sapiens
35 STX18 53407
Affinity Capture-MS Homo sapiens
36 CHST7  
Affinity Capture-MS Homo sapiens
37 TNFSF11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SCFD1 23256
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
40 BNIP1 662
Affinity Capture-MS Homo sapiens
41 FAM9C  
Affinity Capture-MS Homo sapiens
42 BET1L 51272
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
43 Sec24c  
Affinity Capture-MS Mus musculus
44 KRTCAP3 200634
Affinity Capture-MS Homo sapiens
45 Immt  
Affinity Capture-MS Mus musculus
46 GPR182  
Two-hybrid Homo sapiens
47 WIPI1 55062
Affinity Capture-MS Homo sapiens
48 STX6 10228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 STX5 6811
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ELOVL5 60481
Proximity Label-MS Homo sapiens
52 PTAR1 375743
Synthetic Lethality Homo sapiens
Synthetic Lethality Homo sapiens
53 SNAP29 9342
Affinity Capture-MS Homo sapiens
54 CHURC1-FNTB  
Affinity Capture-MS Homo sapiens
55 Rab5c 19345
Affinity Capture-MS Mus musculus
56 HSD3B7 80270
Proximity Label-MS Homo sapiens
57 Myh9 17886
Affinity Capture-MS Mus musculus
58 BTNL9  
Affinity Capture-MS Homo sapiens
59 KIR2DL1  
Affinity Capture-MS Homo sapiens
60 MARCH1  
Affinity Capture-MS Homo sapiens
61 Bmpr1a  
Affinity Capture-MS Mus musculus
62 P2RY2 5029
Affinity Capture-MS Homo sapiens
63 SLC35E1 79939
Affinity Capture-MS Homo sapiens
64 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
65 VAMP3 9341
Affinity Capture-MS Homo sapiens
66 TMEM74  
Affinity Capture-MS Homo sapiens
67 KCNE3  
Affinity Capture-MS Homo sapiens
68 ZW10 9183
Affinity Capture-MS Homo sapiens
69 Uso1 56041
Affinity Capture-MS Mus musculus
70 CLEC12A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 RAB9A 9367
Proximity Label-MS Homo sapiens
72 PPAPDC1A  
Affinity Capture-MS Homo sapiens
73 LMNA 4000
Proximity Label-MS Homo sapiens
74 RNF149 284996
Affinity Capture-MS Homo sapiens
75 PDE3A  
Affinity Capture-MS Homo sapiens
76 PHB2 11331
Co-fractionation Homo sapiens
77 USE1 55850
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 KCNA2  
Affinity Capture-MS Homo sapiens
79 NSF 4905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 Rbm8a  
Affinity Capture-MS Mus musculus
81 VAMP4 8674
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 DSC1 1823
Affinity Capture-MS Homo sapiens
83 SNAP25 6616
Reconstituted Complex Homo sapiens
84 TRAPPC13 80006
Synthetic Lethality Homo sapiens
85 SAAL1 113174
Affinity Capture-MS Homo sapiens
86 PKP1 5317
Affinity Capture-MS Homo sapiens
87 MIF 4282
Affinity Capture-MS Homo sapiens
88 RAB2A 5862
Proximity Label-MS Homo sapiens
89 STX3 6809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PTPRCAP 5790
Affinity Capture-MS Homo sapiens
91 RAB7A 7879
Proximity Label-MS Homo sapiens
92 YKT6 10652
Affinity Capture-Western Homo sapiens
93 EPHA2 1969
Proximity Label-MS Homo sapiens
94 VAMP5 10791
Affinity Capture-MS Homo sapiens
95 RAB5C 5878
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
96 CAV1 857
Proximity Label-MS Homo sapiens
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