Gene description for PCDHGA6
Gene name protocadherin gamma subfamily A, 6
Gene symbol PCDHGA6
Other names/aliases PCDH-GAMMA-A6
Species Homo sapiens
 Database cross references - PCDHGA6
ExoCarta ExoCarta_56109
Vesiclepedia VP_56109
Entrez Gene 56109
HGNC 8704
MIM 606293
UniProt Q9Y5G7  
 PCDHGA6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PCDHGA6
Molecular Function
    calcium ion binding GO:0005509 IEA
Biological Process
    cell adhesion GO:0007155 IBA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    nervous system development GO:0007399 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified PCDHGA6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PCDHGA6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KLHL20  
Affinity Capture-MS Homo sapiens
2 PCDHGA4  
Affinity Capture-MS Homo sapiens
3 TMEM200A 114801
Affinity Capture-MS Homo sapiens
4 B4GALNT1  
Affinity Capture-MS Homo sapiens
5 PCDHGA5  
Affinity Capture-MS Homo sapiens
6 PTPRD 5789
Affinity Capture-MS Homo sapiens
7 GOSR1 9527
Affinity Capture-MS Homo sapiens
8 DCHS1 8642
Affinity Capture-MS Homo sapiens
9 GDF9 2661
Affinity Capture-MS Homo sapiens
10 RYK 6259
Affinity Capture-MS Homo sapiens
11 PCDHGC3 5098
Affinity Capture-MS Homo sapiens
12 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
13 PCDHA9  
Affinity Capture-MS Homo sapiens
14 EFNA3  
Affinity Capture-MS Homo sapiens
15 PCDHGB2  
Affinity Capture-MS Homo sapiens
16 RUVBL1 8607
Affinity Capture-MS Homo sapiens
17 ITFG1 81533
Affinity Capture-MS Homo sapiens
18 RPL23 9349
Affinity Capture-MS Homo sapiens
19 CBX6  
Affinity Capture-MS Homo sapiens
20 LTBP1 4052
Affinity Capture-MS Homo sapiens
21 PCDHGA7 56108
Affinity Capture-MS Homo sapiens
22 EPHB4 2050
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PCDHGA6 is involved
No pathways found





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