Gene description for GDF9
Gene name growth differentiation factor 9
Gene symbol GDF9
Other names/aliases -
Species Homo sapiens
 Database cross references - GDF9
ExoCarta ExoCarta_2661
Vesiclepedia VP_2661
Entrez Gene 2661
HGNC 4224
MIM 601918
UniProt O60383  
 GDF9 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GDF9
Molecular Function
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
    transforming growth factor beta receptor binding GO:0005160 IBA
Biological Process
    positive regulation of cell proliferation GO:0008284 IDA
    oocyte growth GO:0001555 IEA
    BMP signaling pathway GO:0030509 IBA
    SMAD protein signal transduction GO:0060395 IBA
    female gamete generation GO:0007292 TAS
    regulation of progesterone secretion GO:2000870 IMP
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
    negative regulation of cell growth GO:0030308 IEA
    regulation of MAPK cascade GO:0043408 IBA
    cell development GO:0048468 IBA
    regulation of apoptotic process GO:0042981 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified GDF9 in exosomes
1
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GDF9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DLEU1  
Two-hybrid Homo sapiens
2 MYCBP 26292
Two-hybrid Homo sapiens
3 MPHOSPH6 10200
Two-hybrid Homo sapiens
4 SNRPG 6637
Two-hybrid Homo sapiens
5 SMN1 6606
Two-hybrid Homo sapiens
6 ILF3 3609
Two-hybrid Homo sapiens
7 TK1 7083
Two-hybrid Homo sapiens
8 PAFAH1B3 5050
Two-hybrid Homo sapiens
9 C7orf19  
Two-hybrid Homo sapiens
10 SERPINB9 5272
Two-hybrid Homo sapiens
11 PSMD11 5717
Two-hybrid Homo sapiens
12 STRN4 29888
Two-hybrid Homo sapiens
13 CRELD1 78987
Two-hybrid Homo sapiens
14 FOXG1B  
Two-hybrid Homo sapiens
15 SAT  
Two-hybrid Homo sapiens
16 BMPR1A 657
Invivo Homo sapiens
17 MOB4 25843
Two-hybrid Homo sapiens
18 FXYD6  
Two-hybrid Homo sapiens
19 PMF1  
Two-hybrid Homo sapiens
20 BTBD2  
Two-hybrid Homo sapiens
21 NDUFB9 4715
Two-hybrid Homo sapiens
22 KDM1A 23028
Two-hybrid Homo sapiens
23 PRKRA 8575
Two-hybrid Homo sapiens
24 LSM3 27258
Two-hybrid Homo sapiens
25 KIF22  
Two-hybrid Homo sapiens
26 S100A8 6279
Two-hybrid Homo sapiens
27 TRIB3  
Two-hybrid Homo sapiens
28 PCDHA4 56144
Two-hybrid Homo sapiens
29 BMPR2 659
Reconstituted Complex Homo sapiens
30 TDGF1  
Two-hybrid Homo sapiens
31 CCDC53 51019
Two-hybrid Homo sapiens
32 RSRC1  
Two-hybrid Homo sapiens
33 RAB27A 5873
Two-hybrid Homo sapiens
34 CDKN2C  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GDF9 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here