Gene description for AP5B1
Gene name adaptor-related protein complex 5, beta 1 subunit
Gene symbol AP5B1
Other names/aliases AP-5
PP1030
Species Homo sapiens
 Database cross references - AP5B1
ExoCarta ExoCarta_91056
Entrez Gene 91056
HGNC 25104
MIM 614367
UniProt Q2VPB7  
 AP5B1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for AP5B1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    endosomal transport GO:0016197 IMP
    protein transport GO:0015031 IEA
Subcellular Localization
    AP-type membrane coat adaptor complex GO:0030119 IDA
    lysosomal membrane GO:0005765 IDA
 Experiment description of studies that identified AP5B1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for AP5B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDP52  
Two-hybrid Homo sapiens
2 PDLIM7 9260
Two-hybrid Homo sapiens
3 KCNRG  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which AP5B1 is involved
No pathways found





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