Gene description for CAMK2B
Gene name calcium/calmodulin-dependent protein kinase II beta
Gene symbol CAMK2B
Other names/aliases CAM2
CAMK2
CAMKB
Species Homo sapiens
 Database cross references - CAMK2B
ExoCarta ExoCarta_816
Vesiclepedia VP_816
Entrez Gene 816
HGNC 1461
MIM 607707
UniProt Q13554  
 CAMK2B identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CAMK2B
Molecular Function
    actin binding GO:0003779 IEA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IBA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IDA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    ATP binding GO:0005524 IEA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    protein serine kinase activity GO:0106310 IEA
Biological Process
    protein phosphorylation GO:0006468 TAS
    nervous system development GO:0007399 IEA
    positive regulation of neuron projection development GO:0010976 ISS
    regulation of skeletal muscle adaptation GO:0014733 TAS
    cell differentiation GO:0030154 IEA
    protein autophosphorylation GO:0046777 IDA
    regulation of neuronal synaptic plasticity GO:0048168 IBA
    regulation of long-term neuronal synaptic plasticity GO:0048169 TAS
    regulation of synapse structural plasticity GO:0051823 TAS
    regulation of calcium ion transport GO:0051924 TAS
    regulation of dendritic spine development GO:0060998 TAS
    positive regulation of dendritic spine morphogenesis GO:0061003 ISS
    positive regulation of synapse maturation GO:0090129 ISS
    regulation of protein localization to plasma membrane GO:1903076 IBA
    regulation of neuron migration GO:2001222 IMP
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 TAS
    calcium- and calmodulin-dependent protein kinase complex GO:0005954 IDA
    postsynaptic density GO:0014069 IBA
    endocytic vesicle membrane GO:0030666 TAS
    sarcoplasmic reticulum membrane GO:0033017 IEA
    neuron projection GO:0043005 IBA
 Experiment description of studies that identified CAMK2B in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CAMK2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MVP 9961
Two-hybrid Homo sapiens
2 ACOT7 11332
Two-hybrid Homo sapiens
3 GPM6A 2823
Affinity Capture-MS Homo sapiens
4 QARS 5859
Affinity Capture-MS Homo sapiens
5 RBPMS 11030
Two-hybrid Homo sapiens
6 THRB 7068
Two-hybrid Homo sapiens
7 Rad23a  
Affinity Capture-Western Rattus norvegicus
8 MGAT5B  
Two-hybrid Homo sapiens
9 FAM163B  
Affinity Capture-MS Homo sapiens
10 POM121  
Affinity Capture-MS Homo sapiens
11 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ZNF397  
Affinity Capture-MS Homo sapiens
13 ZNF843  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FAM171A2 284069
Two-hybrid Homo sapiens
15 NAA11 84779
Affinity Capture-MS Homo sapiens
16 GABBR1  
Affinity Capture-Western Homo sapiens
17 NUFIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SMYD3 64754
Two-hybrid Homo sapiens
19 CALM3 808
Affinity Capture-MS Homo sapiens
20 MAD2L2 10459
Two-hybrid Homo sapiens
21 PIGH  
Affinity Capture-MS Homo sapiens
22 KRTAP10-11  
Two-hybrid Homo sapiens
23 CAMK2B 816
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 Arc  
Affinity Capture-Western Mus musculus
25 KRTAP19-5  
Two-hybrid Homo sapiens
26 RBM42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 METTL10  
Affinity Capture-MS Homo sapiens
28 PRNP 5621
Affinity Capture-MS Homo sapiens
29 YWHAB 7529
Biochemical Activity Homo sapiens
30 PALD1 27143
Affinity Capture-MS Homo sapiens
31 CALM2 805
Affinity Capture-MS Homo sapiens
32 CAMK2A 815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 DNAL4  
Affinity Capture-MS Homo sapiens
34 RDH8  
Affinity Capture-MS Homo sapiens
35 NDUFA8 4702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 KRTAP19-7  
Two-hybrid Homo sapiens
37 CCM2L  
Two-hybrid Homo sapiens
38 ANGPTL7 10218
Affinity Capture-MS Homo sapiens
39 ACTN4 81
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 TTLL1  
Affinity Capture-MS Homo sapiens
41 TRAPPC2L 51693
Affinity Capture-MS Homo sapiens
42 ARMC1 55156
Affinity Capture-MS Homo sapiens
43 MRPL11 65003
Two-hybrid Homo sapiens
44 VCPIP1 80124
Affinity Capture-MS Homo sapiens
45 TTC5  
Two-hybrid Homo sapiens
46 HSPB8 26353
Affinity Capture-MS Homo sapiens
47 SPRYD7 57213
Two-hybrid Homo sapiens
48 RPL11 6135
Two-hybrid Homo sapiens
49 ATXN1 6310
Two-hybrid Homo sapiens
50 DNAAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 FAM170A  
Affinity Capture-MS Homo sapiens
52 POP5  
Two-hybrid Homo sapiens
53 ASAH1 427
Affinity Capture-MS Homo sapiens
54 ZSCAN1  
Affinity Capture-MS Homo sapiens
55 ELP3 55140
Affinity Capture-MS Homo sapiens
56 NR3C1 2908
Affinity Capture-MS Homo sapiens
57 NUP43 348995
Affinity Capture-MS Homo sapiens
58 MORF4L1  
Two-hybrid Homo sapiens
59 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
60 PHKB 5257
Two-hybrid Homo sapiens
61 AP5B1 91056
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
62 RXRG  
Two-hybrid Homo sapiens
63 SEMA4G  
Two-hybrid Homo sapiens
64 HAX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CAMK2G 818
Affinity Capture-MS Homo sapiens
66 RAP2B 5912
Two-hybrid Homo sapiens
67 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
68 DUS4L  
Affinity Capture-MS Homo sapiens
69 EPB41L4B 54566
Affinity Capture-MS Homo sapiens
70 SHISA6  
Affinity Capture-MS Homo sapiens
71 C20orf96  
Affinity Capture-MS Homo sapiens
72 LIPH 200879
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 MCM5 4174
Affinity Capture-MS Homo sapiens
74 TRAT1 50852
Affinity Capture-MS Homo sapiens
75 MAP10  
Affinity Capture-MS Homo sapiens
76 PRKAG2 51422
Affinity Capture-MS Homo sapiens
77 TKT 7086
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 ZNF764 92595
Affinity Capture-MS Homo sapiens
79 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
80 MAGEA9  
Affinity Capture-MS Homo sapiens
81 GOLGA6L2  
Affinity Capture-MS Homo sapiens
82 C6orf141  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 RBFOX2 23543
Two-hybrid Homo sapiens
84 MED18  
Two-hybrid Homo sapiens
85 PADI4  
Affinity Capture-MS Homo sapiens
86 DGUOK  
Affinity Capture-MS Homo sapiens
87 WDR5B  
Affinity Capture-MS Homo sapiens
88 CAMK2D 817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
89 C9orf72  
Affinity Capture-MS Homo sapiens
90 STRN 6801
Affinity Capture-MS Homo sapiens
91 CCT8L2  
Affinity Capture-MS Homo sapiens
92 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CAMK2B is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Activation of NMDA receptors and postsynaptic events TAS Reactome
Assembly and cell surface presentation of NMDA receptors IEA Reactome
Ca-dependent events IEA Reactome
Calmodulin induced events IEA Reactome
CaM pathway IEA Reactome
CaMK IV-mediated phosphorylation of CREB IEA Reactome
Cardiac conduction TAS Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling IEA Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
DAG and IP3 signaling IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
G alpha (i) signalling events IEA Reactome
G-protein mediated events IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity TAS Reactome
GPCR downstream signalling IEA Reactome
HSF1-dependent transactivation TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Ion channel transport TAS Reactome
Ion homeostasis TAS Reactome
Ion transport by P-type ATPases TAS Reactome
Long-term potentiation IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Muscle contraction TAS Reactome
Negative regulation of NMDA receptor-mediated neuronal transmission IEA Reactome
Neuronal System IEA Reactome
Neuronal System TAS Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission TAS Reactome
Oncogenic MAPK signaling TAS Reactome
Opioid Signalling IEA Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Phase 0 - rapid depolarisation TAS Reactome
PLC beta mediated events IEA Reactome
Post NMDA receptor activation events IEA Reactome
RAF activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Ras activation upon Ca2+ influx through NMDA receptor IEA Reactome
Regulation of MECP2 expression and activity IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Trafficking of AMPA receptors TAS Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transmission across Chemical Synapses IEA Reactome
Transmission across Chemical Synapses TAS Reactome
Transport of small molecules TAS Reactome
Unblocking of NMDA receptors, glutamate binding and activation TAS Reactome
Unblocking of NMDA receptors, glutamate binding and activation IEA Reactome





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