Gene description for CAMK2B
Gene name calcium/calmodulin-dependent protein kinase II beta
Gene symbol CAMK2B
Other names/aliases CAM2
CAMK2
CAMKB
Species Homo sapiens
 Database cross references - CAMK2B
ExoCarta ExoCarta_816
Vesiclepedia VP_816
Entrez Gene 816
HGNC 1461
MIM 607707
UniProt Q13554  
 CAMK2B identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CAMK2B
Molecular Function
    calmodulin-dependent protein kinase activity GO:0004683 IEA
    protein homodimerization activity GO:0042803 IPI
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    actin binding GO:0003779 IEA
    calmodulin binding GO:0005516 IEA
Biological Process
    positive regulation of synapse maturation GO:0090129 ISS
    inhibitory G-protein coupled receptor phosphorylation GO:0002030 IEA
    regulation of long-term neuronal synaptic plasticity GO:0048169 TAS
    regulation of synaptic transmission, cholinergic GO:0032222 IEA
    calcium ion transport GO:0006816 IEA
    regulation of skeletal muscle adaptation GO:0014733 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    protein autophosphorylation GO:0046777 IDA
    positive regulation of neuron projection development GO:0010976 ISS
    peptidyl-serine phosphorylation GO:0018105 IEA
    G1/S transition of mitotic cell cycle GO:0000082 IEA
    regulation of dendritic spine development GO:0060998 TAS
    signal transduction GO:0007165 TAS
    cellular response to heat GO:0034605 TAS
    regulation of synapse structural plasticity GO:0051823 TAS
    positive regulation of apoptotic signaling pathway GO:2001235 IEA
    protein phosphorylation GO:0006468 TAS
    positive regulation of dendritic spine morphogenesis GO:0061003 ISS
    regulation of cellular response to heat GO:1900034 TAS
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    regulation of calcium ion transport GO:0051924 TAS
    neuromuscular process controlling balance GO:0050885 IEA
    activation of meiosis involved in egg activation GO:0060466 IEA
    response to cadmium ion GO:0046686 IEA
    synaptic transmission GO:0007268 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    spindle midzone GO:0051233 IEA
    nucleoplasm GO:0005654 TAS
    sarcoplasmic reticulum membrane GO:0033017 IEA
    plasma membrane GO:0005886 TAS
    endocytic vesicle membrane GO:0030666 TAS
    microtubule organizing center GO:0005815 IEA
 Experiment description of studies that identified CAMK2B in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CAMK2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAMK2A 815
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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