Gene description for ELP3
Gene name elongator acetyltransferase complex subunit 3
Gene symbol ELP3
Other names/aliases KAT9
Species Homo sapiens
 Database cross references - ELP3
ExoCarta ExoCarta_55140
Entrez Gene 55140
HGNC 20696
MIM 612722
UniProt Q9H9T3  
 ELP3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ELP3
Molecular Function
    iron-sulfur cluster binding GO:0051536 IEA
    phosphorylase kinase regulator activity GO:0008607 IDA
    H3 histone acetyltransferase activity GO:0010484 IDA
    H4 histone acetyltransferase activity GO:0010485 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II core binding GO:0000993 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    histone H3 acetylation GO:0043966 IDA
    transcription elongation from RNA polymerase II promoter GO:0006368 TAS
    positive regulation of cell migration GO:0030335 ISS
    neuron migration GO:0001764 ISS
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    histone H4 acetylation GO:0043967 IDA
    regulation of protein kinase activity GO:0045859 IDA
    tRNA wobble uridine modification GO:0002098 IBA
    central nervous system development GO:0007417 ISS
    chromatin organization GO:0006325 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleolus GO:0005730 IDA
    Elongator holoenzyme complex GO:0033588 IDA
    transcription elongation factor complex GO:0008023 IDA
    histone acetyltransferase complex GO:0000123 IDA
 Experiment description of studies that identified ELP3 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ELP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2A 5430
Co-purification Homo sapiens
2 IKBKAP 8518
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Co-purification Homo sapiens
View the network image/svg+xml
 Pathways in which ELP3 is involved
HATs acetylate histones TAS Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here