Gene description for TRAT1
Gene name T cell receptor associated transmembrane adaptor 1
Gene symbol TRAT1
Other names/aliases HSPC062
TCRIM
TRIM
Species Homo sapiens
 Database cross references - TRAT1
ExoCarta ExoCarta_50852
Entrez Gene 50852
HGNC 30698
MIM 604962
UniProt Q6PIZ9  
 TRAT1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TRAT1
Molecular Function
    transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 TAS
Biological Process
    signal transduction GO:0007165 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    negative regulation of transport GO:0051051 IDA
    innate immune response GO:0045087 TAS
    negative regulation of receptor recycling GO:0001920 IDA
    T cell receptor signaling pathway GO:0050852 TAS
    positive regulation of calcium-mediated signaling GO:0050850 IDA
    cellular defense response GO:0006968 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of T cell receptor signaling pathway GO:0050862 IDA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    intracellular GO:0005622 TAS
    T cell receptor complex GO:0042101 IDA
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified TRAT1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRAT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Reconstituted Complex Homo sapiens
2 CD247 919
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 TRA@  
Affinity Capture-MS Homo sapiens
4 LCK 3932
Reconstituted Complex Homo sapiens
5 FYN 2534
Reconstituted Complex Homo sapiens
6 GRB2 2885
Reconstituted Complex Homo sapiens
7 LCP2 3937
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here