Gene description for LCK
Gene name	LCK proto-oncogene, Src family tyrosine kinase
Gene symbol	LCK
Other names/aliases	IMD22 LSK YT16 p56lck pp58lck
Species	Homo sapiens
Database cross references - LCK
ExoCarta	ExoCarta_3932
Entrez Gene	3932
HGNC	6524
MIM	153390
UniProt	P06239
LCK identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Neuroblastoma cells	25944692
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for LCK

Molecular Function     CD8 receptor binding GO:0042610 IPI     protein C-terminus binding GO:0008022 IPI     protein phosphatase binding GO:0019903 IPI     identical protein binding GO:0042802 IPI     protein tyrosine kinase activity GO:0004713 TAS     protein complex binding GO:0032403 IEA     phosphatidylinositol 3-kinase binding GO:0043548 IPI     ATPase binding GO:0051117 IPI     antigen binding GO:0003823 IEA     glycoprotein binding GO:0001948 IPI     protein binding GO:0005515 IPI     SH2 domain binding GO:0042169 ISS     protein serine/threonine phosphatase activity GO:0004722 ISS     protein kinase binding GO:0019901 IPI     CD4 receptor binding GO:0042609 IPI     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     ATP binding GO:0005524 IEA Biological Process     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISS     hemopoiesis GO:0030097 NAS     leukocyte migration GO:0050900 TAS     B cell receptor signaling pathway GO:0050853 IBA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISS     positive regulation of T cell receptor signaling pathway GO:0050862 NAS     blood coagulation GO:0007596 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     platelet activation GO:0030168 TAS     release of sequestered calcium ion into cytosol GO:0051209 ISS     response to mechanical stimulus GO:0009612 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     positive regulation of gamma-delta T cell differentiation GO:0045588 IEA     positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 IEA     dephosphorylation GO:0016311 ISS     cellular response to peptide hormone stimulus GO:0071375 IBA     viral process GO:0016032 TAS     cellular zinc ion homeostasis GO:0006882 ISS     T cell costimulation GO:0031295 TAS     T cell differentiation GO:0030217 ISS     T cell receptor signaling pathway GO:0050852 TAS     regulation of lymphocyte activation GO:0051249 NAS     response to zinc ion GO:0010043 IEA     response to drug GO:0042493 ISS     positive regulation of gene expression GO:0010628 IEA     aging GO:0007568 IEA     regulation of defense response to virus by virus GO:0050690 TAS     response to hydrogen peroxide GO:0042542 IEA     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     innate immune response GO:0045087 TAS     positive regulation of uterine smooth muscle contraction GO:0070474 IEA     positive regulation of T cell activation GO:0050870 ISS     regulation of cell proliferation GO:0042127 IBA     phosphatidylinositol-mediated signaling GO:0048015 TAS     protein phosphorylation GO:0006468 IDA Subcellular Localization     membrane raft GO:0045121 ISS     endocytic vesicle GO:0030139 IEA     extracellular exosome GO:0070062 IDA     plasma membrane GO:0005886 TAS     immunological synapse GO:0001772 IDA     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     cytosol GO:0005829 TAS     cell-cell junction GO:0005911 IEA     pericentriolar material GO:0000242 ISS