Gene description for LCK
Gene name LCK proto-oncogene, Src family tyrosine kinase
Gene symbol LCK
Other names/aliases IMD22
LSK
YT16
p56lck
pp58lck
Species Homo sapiens
 Database cross references - LCK
ExoCarta ExoCarta_3932
Vesiclepedia VP_3932
Entrez Gene 3932
HGNC 6524
MIM 153390
UniProt P06239  
 LCK identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Colorectal cancer cells 34887515    
Neuroblastoma cells 25944692    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
 Gene ontology annotations for LCK
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 IMP
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    protein serine/threonine phosphatase activity GO:0004722 IDA
    signaling receptor binding GO:0005102 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    phospholipase activator activity GO:0016004 IDA
    protein kinase binding GO:0019901 IPI
    protein phosphatase binding GO:0019903 IPI
    histone H3Y41 kinase activity GO:0035401 IEA
    SH2 domain binding GO:0042169 IPI
    T cell receptor binding GO:0042608 IPI
    CD4 receptor binding GO:0042609 IPI
    CD8 receptor binding GO:0042610 IPI
    identical protein binding GO:0042802 IPI
    phospholipase binding GO:0043274 IPI
    phosphatidylinositol 3-kinase binding GO:0043548 IPI
    ATPase binding GO:0051117 IPI
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    intracellular zinc ion homeostasis GO:0006882 IEP
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    response to xenobiotic stimulus GO:0009410 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IMP
    hemopoiesis GO:0030097 NAS
    platelet activation GO:0030168 TAS
    T cell differentiation GO:0030217 IBA
    T cell differentiation GO:0030217 IMP
    T cell costimulation GO:0031295 TAS
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IMP
    intracellular signal transduction GO:0035556 IDA
    peptidyl-tyrosine autophosphorylation GO:0038083 IDA
    Fc-gamma receptor signaling pathway GO:0038094 IDA
    T cell activation GO:0042110 IDA
    T cell receptor signaling pathway GO:0050852 IDA
    T cell receptor signaling pathway GO:0050852 TAS
    B cell receptor signaling pathway GO:0050853 IBA
    positive regulation of T cell receptor signaling pathway GO:0050862 NAS
    positive regulation of T cell activation GO:0050870 IDA
    leukocyte migration GO:0050900 TAS
    release of sequestered calcium ion into cytosol GO:0051209 ISS
    regulation of lymphocyte activation GO:0051249 NAS
    CD27 signaling pathway GO:0160162 IDA
    positive regulation of leukocyte cell-cell adhesion GO:1903039 IMP
    positive regulation of cysteine-type endopeptidase activity GO:2001056 IDA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IMP
Subcellular Localization
    pericentriolar material GO:0000242 IDA
    immunological synapse GO:0001772 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane raft GO:0045121 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified LCK in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
5
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
6
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LCK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KIF16B 55614
Proximity Label-MS Homo sapiens
2 AXL 558
Far Western Homo sapiens
3 AFG3L2 10939
Proximity Label-MS Homo sapiens
4 SPTAN1 6709
Proximity Label-MS Homo sapiens
5 DLG5 9231
Proximity Label-MS Homo sapiens
6 USP6NL 9712
Proximity Label-MS Homo sapiens
7 UTRN 7402
Proximity Label-MS Homo sapiens
8 SLC30A6 55676
Proximity Label-MS Homo sapiens
9 PARD3 56288
Proximity Label-MS Homo sapiens
10 CDC42BPB 9578
Proximity Label-MS Homo sapiens
11 TRIO 7204
Proximity Label-MS Homo sapiens
12 CDK3 1018
Proximity Label-MS Homo sapiens
13 OCLN 100506658
Proximity Label-MS Homo sapiens
14 CEP89 84902
Proximity Label-MS Homo sapiens
15 CD48 962
Affinity Capture-Western Homo sapiens
16 NOS1AP  
Proximity Label-MS Homo sapiens
17 LLGL1 3996
Proximity Label-MS Homo sapiens
18 PKP2 5318
Proximity Label-MS Homo sapiens
19 SQSTM1 8878
Reconstituted Complex Homo sapiens
20 EFR3A 23167
Proximity Label-MS Homo sapiens
21 FAM166B  
Two-hybrid Homo sapiens
22 CD4 920
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
23 ARHGAP21 57584
Proximity Label-MS Homo sapiens
24 JPH1 56704
Proximity Label-MS Homo sapiens
25 G3BP1 10146
Biochemical Activity Homo sapiens
26 EPB41L5 57669
Proximity Label-MS Homo sapiens
27 PAK2 5062
Reconstituted Complex Homo sapiens
28 BRCA1 672
Two-hybrid Homo sapiens
29 DTNA  
Proximity Label-MS Homo sapiens
30 UBE3A 7337
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
31 NAV1 89796
Proximity Label-MS Homo sapiens
32 SOCS1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
33 UBC 7316
Protein-peptide Homo sapiens
Co-crystal Structure Homo sapiens
34 ARAP2  
Proximity Label-MS Homo sapiens
35 FMN2  
Proximity Label-MS Homo sapiens
36 BASP1 10409
Proximity Label-MS Homo sapiens
37 WDR6 11180
Proximity Label-MS Homo sapiens
38 HSPA1A 3303
Proximity Label-MS Homo sapiens
39 PALM2  
Proximity Label-MS Homo sapiens
40 SNX6 58533
Proximity Label-MS Homo sapiens
41 SLC12A2 6558
Proximity Label-MS Homo sapiens
42 PI4KA 5297
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
43 CD247 919
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 IL21R  
Negative Genetic Homo sapiens
45 ARHGAP32  
Proximity Label-MS Homo sapiens
46 MET 4233
Reconstituted Complex Homo sapiens
47 RPS11 6205
Proximity Label-MS Homo sapiens
48 WAS 7454
Affinity Capture-Western Homo sapiens
49 PPFIBP1 8496
Proximity Label-MS Homo sapiens
50 MARK2 2011
Proximity Label-MS Homo sapiens
51 EDRF1  
Proximity Label-MS Homo sapiens
52 CNOT10 25904
Proximity Label-MS Homo sapiens
53 DSTN 11034
Proximity Label-MS Homo sapiens
54 USO1 8615
Proximity Label-MS Homo sapiens
55 CTLA4  
Affinity Capture-Western Homo sapiens
56 FAM171A2 284069
Proximity Label-MS Homo sapiens
57 PALM2-AKAP2 445815
Proximity Label-MS Homo sapiens
58 EXOC3 11336
Proximity Label-MS Homo sapiens
59 TRIM35 23087
Two-hybrid Homo sapiens
60 AP2A1 160
Proximity Label-MS Homo sapiens
61 ZAP70 7535
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
62 FAM174A 345757
Protein-peptide Homo sapiens
63 EXOC5 10640
Proximity Label-MS Homo sapiens
64 CD2 914
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
65 RAI14 26064
Proximity Label-MS Homo sapiens
66 CD55 1604
Co-localization Homo sapiens
67 NPM1 4869
Proximity Label-MS Homo sapiens
68 KHDRBS1 10657
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
69 SYK 6850
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
70 ASB9  
Two-hybrid Homo sapiens
71 CD3E 916
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
72 RASAL2 9462
Proximity Label-MS Homo sapiens
73 RPS9 6203
Proximity Label-MS Homo sapiens
74 IRS4 8471
Proximity Label-MS Homo sapiens
75 STIP1 10963
Proximity Label-MS Homo sapiens
76 MYO1B 4430
Proximity Label-MS Homo sapiens
77 PEAK1 79834
Proximity Label-MS Homo sapiens
78 MAD2L2 10459
Proximity Label-MS Homo sapiens
79 TOMM34 10953
Proximity Label-MS Homo sapiens
80 PTPN14 5784
Proximity Label-MS Homo sapiens
81 DNAJC7 7266
Proximity Label-MS Homo sapiens
82 RAB11FIP1 80223
Proximity Label-MS Homo sapiens
83 GOLGA4  
Proximity Label-MS Homo sapiens
84 Mbp 17196
Protein-peptide Mus musculus
85 PALM 5064
Proximity Label-MS Homo sapiens
86 CTNNA1 1495
Proximity Label-MS Homo sapiens
87 SOCS3 9021
Affinity Capture-Western Homo sapiens
88 PTPN22  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
89 CBLB 868
Affinity Capture-Western Homo sapiens
90 ABI1 10006
Proximity Label-MS Homo sapiens
91 ERBB2 2064
Reconstituted Complex Homo sapiens
92 DIP2A 23181
Proximity Label-MS Homo sapiens
93 DDX54 79039
Proximity Label-MS Homo sapiens
94 OBSL1 23363
Affinity Capture-MS Homo sapiens
95 KIAA1804  
Proximity Label-MS Homo sapiens
96 KIF14 9928
Affinity Capture-MS Homo sapiens
97 CBL 867
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
98 NOTCH2 4853
Proximity Label-MS Homo sapiens
99 FAS 355
Reconstituted Complex Homo sapiens
100 CCT2 10576
Proximity Label-MS Homo sapiens
101 PFKP 5214
Proximity Label-MS Homo sapiens
102 COBLL1 22837
Proximity Label-MS Homo sapiens
103 NFKBID  
Two-hybrid Homo sapiens
104 EPB41L3 23136
Proximity Label-MS Homo sapiens
105 PFKM 5213
Proximity Label-MS Homo sapiens
106 NEDD9 4739
Affinity Capture-Western Homo sapiens
107 AP3M1 26985
Proximity Label-MS Homo sapiens
108 BCAR1 9564
Reconstituted Complex Homo sapiens
109 GLMN 11146
Proximity Label-MS Homo sapiens
110 KIT 3815
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
111 FASLG 356
Reconstituted Complex Homo sapiens
112 PPFIA1 8500
Proximity Label-MS Homo sapiens
113 TTC4  
Proximity Label-MS Homo sapiens
114 CEP55 55165
Proximity Label-MS Homo sapiens
115 ST13 6767
Proximity Label-MS Homo sapiens
116 TTC9C 283237
Proximity Label-MS Homo sapiens
117 ERBB3 2065
Reconstituted Complex Homo sapiens
118 DRG1 4733
Proximity Label-MS Homo sapiens
119 RORB  
Two-hybrid Homo sapiens
120 OCRL 4952
Proximity Label-MS Homo sapiens
121 TNKS1BP1 85456
Proximity Label-MS Homo sapiens
122 BAG6 7917
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 GOLGA2 2801
Proximity Label-MS Homo sapiens
124 VANGL1 81839
Proximity Label-MS Homo sapiens
125 AMOT 154796
Proximity Label-MS Homo sapiens
126 GCC2 9648
Proximity Label-MS Homo sapiens
127 CASKIN2  
Proximity Label-MS Homo sapiens
128 PAG1 55824
Reconstituted Complex Homo sapiens
129 FGD1  
Proximity Label-MS Homo sapiens
130 MAPT  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
131 CDKAL1  
Two-hybrid Homo sapiens
132 CHMP4B 128866
Affinity Capture-MS Homo sapiens
133 NELFE 7936
Affinity Capture-MS Homo sapiens
134 NUDC 10726
Proximity Label-MS Homo sapiens
135 STUB1 10273
Proximity Label-MS Homo sapiens
136 TANC1 85461
Proximity Label-MS Homo sapiens
137 ANK3  
Proximity Label-MS Homo sapiens
138 SYNJ1 8867
Proximity Label-MS Homo sapiens
139 PTK2B 2185
Affinity Capture-Western Homo sapiens
140 TARS2 80222
Proximity Label-MS Homo sapiens
141 FERMT2 10979
Proximity Label-MS Homo sapiens
142 KIAA1522 57648
Proximity Label-MS Homo sapiens
143 YWHAQ 10971
Affinity Capture-Western Homo sapiens
144 UNC119 9094
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
145 AIP 9049
Proximity Label-MS Homo sapiens
146 PIK3R1 5295
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
147 CD38 952
Affinity Capture-Western Homo sapiens
148 ARL13B 200894
Proximity Label-MS Homo sapiens
149 MPP7 143098
Proximity Label-MS Homo sapiens
150 Cd3e  
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
151 FLOT2 2319
Proximity Label-MS Homo sapiens
152 ANKRD26 22852
Proximity Label-MS Homo sapiens
153 PECAM1 5175
Biochemical Activity Homo sapiens
154 GOLGA5 9950
Proximity Label-MS Homo sapiens
155 USP54 159195
Proximity Label-MS Homo sapiens
156 UBXN6 80700
Proximity Label-MS Homo sapiens
157 NUDCD3 23386
Proximity Label-MS Homo sapiens
158 ACBD3 64746
Proximity Label-MS Homo sapiens
159 AP3S1 1176
Proximity Label-MS Homo sapiens
160 BAG3 9531
Proximity Label-MS Homo sapiens
161 ARHGAP17 55114
Reconstituted Complex Homo sapiens
162 NCKAP5L  
Proximity Label-MS Homo sapiens
163 DST 667
Proximity Label-MS Homo sapiens
164 C1QTNF2  
Two-hybrid Homo sapiens
165 MINK1 50488
Proximity Label-MS Homo sapiens
166 LAT 27040
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
167 EPB41L1 2036
Proximity Label-MS Homo sapiens
168 DIP2B 57609
Proximity Label-MS Homo sapiens
169 SOCS2  
Affinity Capture-Western Homo sapiens
170 GOLGA3 2802
Proximity Label-MS Homo sapiens
171 FAM129B 64855
Proximity Label-MS Homo sapiens
172 PRPF4B 8899
Proximity Label-MS Homo sapiens
173 SIPA1L2  
Proximity Label-MS Homo sapiens
174 CHORDC1 26973
Proximity Label-MS Homo sapiens
175 LMTK2 22853
Proximity Label-MS Homo sapiens
176 RPL7A 6130
Proximity Label-MS Homo sapiens
177 CSTF2T  
Proximity Label-MS Homo sapiens
178 PTPN6 5777
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
179 CDCA3 83461
Proximity Label-MS Homo sapiens
180 UBAP2 55833
Two-hybrid Homo sapiens
181 ATP2B1 490
Proximity Label-MS Homo sapiens
182 STIM1 6786
Proximity Label-MS Homo sapiens
183 ERBB2IP 55914
Proximity Label-MS Homo sapiens
184 KIAA1217 56243
Proximity Label-MS Homo sapiens
185 PPID 5481
Proximity Label-MS Homo sapiens
186 NUMB 8650
Proximity Label-MS Homo sapiens
187 DLG1 1739
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
188 FAM171A1 221061
Proximity Label-MS Homo sapiens
189 PLCH1  
Proximity Label-MS Homo sapiens
190 CNP 1267
Proximity Label-MS Homo sapiens
191 CUL3 8452
Affinity Capture-MS Homo sapiens
192 NR3C1 2908
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
193 ERBB4 2066
Reconstituted Complex Homo sapiens
194 UHRF2  
Far Western Homo sapiens
195 EGFR 1956
Reconstituted Complex Homo sapiens
196 MYO5A 4644
Proximity Label-MS Homo sapiens
197 EGLN1 54583
Proximity Label-MS Homo sapiens
198 PLEKHA7 144100
Proximity Label-MS Homo sapiens
199 PKN3 29941
Proximity Label-MS Homo sapiens
200 LRRC16A 55604
Proximity Label-MS Homo sapiens
201 MYO1C 4641
Proximity Label-MS Homo sapiens
202 GAB1  
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
203 PLEKHA5 54477
Proximity Label-MS Homo sapiens
204 COG1 9382
Proximity Label-MS Homo sapiens
205 AURKB 9212
Proximity Label-MS Homo sapiens
206 LZTS2 84445
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
207 PRKCQ 5588
Two-hybrid Homo sapiens
208 CD5 921
Affinity Capture-Western Homo sapiens
209 MYO1D 4642
Proximity Label-MS Homo sapiens
210 IL2RB  
Affinity Capture-Western Homo sapiens
211 MYO6 4646
Proximity Label-MS Homo sapiens
212 PTPN13 5783
Proximity Label-MS Homo sapiens
213 SLC3A2 6520
Proximity Label-MS Homo sapiens
214 PKP4 8502
Proximity Label-MS Homo sapiens
215 YARS 8565
Proximity Label-MS Homo sapiens
216 CABLES1  
Proximity Label-MS Homo sapiens
217 PIK3CA 5290
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
218 CSNK2B 1460
Two-hybrid Homo sapiens
219 KALRN 8997
Proximity Label-MS Homo sapiens
220 MAP4K4 9448
Proximity Label-MS Homo sapiens
221 RAF1 5894
Affinity Capture-Western Homo sapiens
222 SIT1 27240
Affinity Capture-Western Homo sapiens
223 FLII 2314
Proximity Label-MS Homo sapiens
224 KIAA1671  
Proximity Label-MS Homo sapiens
225 CRYBG3  
Proximity Label-MS Homo sapiens
226 SEPT7 989
Proximity Label-MS Homo sapiens
227 ETFA 2108
Proximity Label-MS Homo sapiens
228 IFNL1  
Negative Genetic Homo sapiens
229 TRPV4 59341
Affinity Capture-Western Homo sapiens
230 KIDINS220 57498
Proximity Label-MS Homo sapiens
231 NUMBL 9253
Proximity Label-MS Homo sapiens
232 EFNB2 1948
Proximity Label-MS Homo sapiens
233 GPRIN1 114787
Proximity Label-MS Homo sapiens
234 IL6R  
Negative Genetic Homo sapiens
235 THY1 7070
Affinity Capture-Western Homo sapiens
236 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
237 FLOT1 10211
Proximity Label-MS Homo sapiens
238 FARP1 10160
Proximity Label-MS Homo sapiens
239 CCDC8  
Proximity Label-MS Homo sapiens
240 GOLGB1 2804
Proximity Label-MS Homo sapiens
241 DSC2 1824
Proximity Label-MS Homo sapiens
242 ADAM10 102
Affinity Capture-Western Homo sapiens
243 RASA1 5921
Biochemical Activity Homo sapiens
244 MARK3 4140
Proximity Label-MS Homo sapiens
245 SUGT1 10910
Proximity Label-MS Homo sapiens
246 SPTBN1 6711
Proximity Label-MS Homo sapiens
247 GPRIN3  
Proximity Label-MS Homo sapiens
248 KIAA1549  
Proximity Label-MS Homo sapiens
249 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
250 DSG2 1829
Proximity Label-MS Homo sapiens
251 PLEKHA6 22874
Proximity Label-MS Homo sapiens
252 ZDHHC5 25921
Proximity Label-MS Homo sapiens
253 TTC1 7265
Proximity Label-MS Homo sapiens
254 PTPRC 5788
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
255 CTDSP1 58190
Two-hybrid Homo sapiens
256 EXOC4 60412
Proximity Label-MS Homo sapiens
257 DNM2 1785
Proximity Label-MS Homo sapiens
258 JUP 3728
Proximity Label-MS Homo sapiens
259 TOMM22 56993
Proximity Label-MS Homo sapiens
260 MACF1 23499
Proximity Label-MS Homo sapiens
261 SPTBN2 6712
Proximity Label-MS Homo sapiens
262 PSD3 23362
Proximity Label-MS Homo sapiens
263 FAM171B  
Proximity Label-MS Homo sapiens
264 LSR 51599
Proximity Label-MS Homo sapiens
265 DNAJA2 10294
Proximity Label-MS Homo sapiens
266 RICTOR 253260
Proximity Label-MS Homo sapiens
267 XPR1 9213
Proximity Label-MS Homo sapiens
268 SH2B3  
Affinity Capture-Western Homo sapiens
269 CDC37 11140
Proximity Label-MS Homo sapiens
270 IKBKG 8517
Reconstituted Complex Homo sapiens
271 AJUBA  
Two-hybrid Homo sapiens
272 LCK 3932
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
273 MS4A1 931
Affinity Capture-Western Homo sapiens
274 SMURF1 57154
Biochemical Activity Homo sapiens
275 TRAT1 50852
Reconstituted Complex Homo sapiens
276 SOS1 6654
Protein-peptide Homo sapiens
277 FKBP4 2288
Proximity Label-MS Homo sapiens
278 NISCH 11188
Proximity Label-MS Homo sapiens
279 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
280 ADAM15 8751
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
281 CDC42BPA 8476
Proximity Label-MS Homo sapiens
282 TRIP11 9321
Proximity Label-MS Homo sapiens
283 CDK1 983
Proximity Label-MS Homo sapiens
284 UNC45A 55898
Proximity Label-MS Homo sapiens
285 ROR2 4920
Proximity Label-MS Homo sapiens
286 PHLDB3  
Proximity Label-MS Homo sapiens
287 MPRIP 23164
Proximity Label-MS Homo sapiens
288 NF1 4763
Proximity Label-MS Homo sapiens
289 SKAP1 8631
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
290 PPP1R13B  
Proximity Label-MS Homo sapiens
291 RPL15 6138
Proximity Label-MS Homo sapiens
292 SCRIB 23513
Proximity Label-MS Homo sapiens
293 PHACTR4 65979
Proximity Label-MS Homo sapiens
294 SNAP23 8773
Proximity Label-MS Homo sapiens
295 FRS2 10818
Proximity Label-MS Homo sapiens
296 PXN 5829
Affinity Capture-Western Homo sapiens
297 Lck 16818
Affinity Capture-MS Mus musculus
298 RPS8 6202
Proximity Label-MS Homo sapiens
299 CISH  
Affinity Capture-Western Homo sapiens
300 PFKL 5211
Proximity Label-MS Homo sapiens
301 EPHA2 1969
Proximity Label-MS Homo sapiens
302 PIH1D1  
Proximity Label-MS Homo sapiens
303 PIK3R2 5296
Proximity Label-MS Homo sapiens
304 CCDC88A 55704
Proximity Label-MS Homo sapiens
305 CD44 960
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
306 AR 367
Reconstituted Complex Homo sapiens
307 SNTB2 6645
Proximity Label-MS Homo sapiens
308 AP3D1 8943
Proximity Label-MS Homo sapiens
309 HAVCR2  
Affinity Capture-Western Homo sapiens
310 AHNAK2 113146
Proximity Label-MS Homo sapiens
311 CACYBP 27101
Proximity Label-MS Homo sapiens
312 NOTCH1 4851
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
313 EP300 2033
Affinity Capture-MS Homo sapiens
314 CTNND1 1500
Biochemical Activity Homo sapiens
Proximity Label-MS Homo sapiens
315 EFR3B  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LCK is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
CD28 co-stimulation TAS Reactome
CD28 dependent PI3K/Akt signaling TAS Reactome
CD28 dependent Vav1 pathway TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Costimulation by the CD28 family TAS Reactome
CTLA4 inhibitory signaling TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DAP12 interactions TAS Reactome
DAP12 interactions IEA Reactome
DAP12 signaling TAS Reactome
DAP12 signaling IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream TCR signaling TAS Reactome
FLT3 Signaling TAS Reactome
FLT3 signaling through SRC family kinases TAS Reactome
Generation of second messenger molecules TAS Reactome
GPVI-mediated activation cascade TAS Reactome
Hemostasis TAS Reactome
HIV Infection TAS Reactome
Host Interactions of HIV factors TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-2 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
Nef and signal transduction TAS Reactome
Nef Mediated CD4 Down-regulation TAS Reactome
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
PD-1 signaling TAS Reactome
PECAM1 interactions TAS Reactome
Phosphorylation of CD3 and TCR zeta chains TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Regulation of KIT signaling TAS Reactome
RHO GTPase cycle TAS Reactome
RHOH GTPase cycle TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by KIT in disease TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by SCF-KIT IEA Reactome
TCR signaling TAS Reactome
The role of Nef in HIV-1 replication and disease pathogenesis TAS Reactome
Translocation of ZAP-70 to Immunological synapse TAS Reactome
Viral Infection Pathways TAS Reactome





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