Gene description for UNC119
Gene name unc-119 homolog (C. elegans)
Gene symbol UNC119
Other names/aliases HRG4
IMD13
POC7
POC7A
Species Homo sapiens
 Database cross references - UNC119
ExoCarta ExoCarta_9094
Vesiclepedia VP_9094
Entrez Gene 9094
HGNC 12565
MIM 604011
UniProt Q13432  
 UNC119 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for UNC119
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IDA
Biological Process
    lipoprotein transport GO:0042953 IDA
    synaptic transmission GO:0007268 TAS
    negative regulation of clathrin-mediated endocytosis GO:1900186 ISS
    endocytosis GO:0006897 IEA
    positive regulation of protein tyrosine kinase activity GO:0061098 IMP
    negative regulation of caveolin-mediated endocytosis GO:2001287 ISS
    phototransduction GO:0007602 TAS
    visual perception GO:0007601 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    spindle midzone GO:0051233 IDA
    intercellular bridge GO:0045171 IDA
    centrosome GO:0005813 IDA
    spindle pole GO:0000922 IDA
 Experiment description of studies that identified UNC119 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UNC119
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASH2L 9070
Two-hybrid Homo sapiens
2 HSPE1 3336
Two-hybrid Homo sapiens
3 LYN 4067
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 TRDMT1  
Two-hybrid Homo sapiens
5 ARL2 402
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
6 COX17  
Two-hybrid Homo sapiens
7 RIPX  
Two-hybrid Homo sapiens
8 MPHOSPH6 10200
Two-hybrid Homo sapiens
9 TK1 7083
Two-hybrid Homo sapiens
10 UBQLN4 56893
Two-hybrid Homo sapiens
11 SMN1 6606
Two-hybrid Homo sapiens
12 ITSN1 6453
Two-hybrid Homo sapiens
13 FKBPL  
Two-hybrid Homo sapiens
14 RGL2 5863
Two-hybrid Homo sapiens
15 MRPS12  
Two-hybrid Homo sapiens
16 PPAP2C 8612
Two-hybrid Homo sapiens
17 HMGB1 3146
Two-hybrid Homo sapiens
18 CETN3  
Two-hybrid Homo sapiens
19 C7orf19  
Two-hybrid Homo sapiens
20 ERH 2079
Two-hybrid Homo sapiens
21 BRIX1 55299
Two-hybrid Homo sapiens
22 GSTM4 2948
Two-hybrid Homo sapiens
23 PPA1 5464
Two-hybrid Homo sapiens
24 CD4 920
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
25 ARL15 54622
Two-hybrid Homo sapiens
26 PHF10  
Two-hybrid Homo sapiens
27 SEPHS1 22929
Two-hybrid Homo sapiens
28 SULT1E1 6783
Two-hybrid Homo sapiens
29 ZFP64  
Two-hybrid Homo sapiens
30 LCK 3932
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
31 PSMD2 5708
Two-hybrid Homo sapiens
32 CYB561D2 11068
Two-hybrid Homo sapiens
33 SAT  
Two-hybrid Homo sapiens
34 RFC5 5985
Two-hybrid Homo sapiens
35 FXYD6  
Two-hybrid Homo sapiens
36 SERPINB9 5272
Two-hybrid Homo sapiens
37 ARF4L  
Two-hybrid Homo sapiens
38 PSMD11 5717
Two-hybrid Homo sapiens
39 HCK 3055
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
40 EIF2S2 8894
Two-hybrid Homo sapiens
41 IL5RA  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
42 PTPRS 5802
Two-hybrid Homo sapiens
43 GIPC2 54810
Two-hybrid Homo sapiens
44 ANXA3 306
Two-hybrid Homo sapiens
45 MGC17624  
Two-hybrid Homo sapiens
46 CD247 919
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
47 CDC42 998
Two-hybrid Homo sapiens
48 CCL18  
Two-hybrid Homo sapiens
49 PFN1 5216
Two-hybrid Homo sapiens
50 TP53BP2  
Two-hybrid Homo sapiens
51 BTBD2  
Two-hybrid Homo sapiens
52 UBE2I 7329
Two-hybrid Homo sapiens
53 KDM1A 23028
Two-hybrid Homo sapiens
54 ARL3 403
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
55 S100A4 6275
Two-hybrid Homo sapiens
56 Tmsb4x  
Two-hybrid Mus musculus
57 FYN 2534
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
58 UBE2B 7320
Two-hybrid Homo sapiens
59 ZNF24  
Two-hybrid Homo sapiens
60 HLA-DQA1 3117
Two-hybrid Homo sapiens
61 PAPSS1 9061
Two-hybrid Homo sapiens
62 CBX8 57332
Two-hybrid Homo sapiens
63 ANKRD24 170961
Two-hybrid Homo sapiens
64 S100A8 6279
Two-hybrid Homo sapiens
65 PCDHA4 56144
Two-hybrid Homo sapiens
66 LUC7L2 51631
Two-hybrid Homo sapiens
67 QTRT1 81890
Two-hybrid Homo sapiens
68 LAMA4 3910
Two-hybrid Homo sapiens
69 CKS2  
Two-hybrid Homo sapiens
70 TP53I3  
Two-hybrid Homo sapiens
71 PAFAH1B3 5050
Two-hybrid Homo sapiens
72 RPA2 6118
Two-hybrid Homo sapiens
73 MAPK10 5602
Two-hybrid Homo sapiens
74 HSPB3  
Two-hybrid Homo sapiens
75 ALDH2 217
Two-hybrid Homo sapiens
76 CDKN2C  
Two-hybrid Homo sapiens
77 BCR 613
Two-hybrid Homo sapiens
78 ID2  
Two-hybrid Homo sapiens
79 CKMT2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which UNC119 is involved
No pathways found





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