Gene description for FAM13A
Gene name family with sequence similarity 13, member A
Gene symbol FAM13A
Other names/aliases ARHGAP48
FAM13A1
Species Homo sapiens
 Database cross references - FAM13A
ExoCarta ExoCarta_10144
Vesiclepedia VP_10144
Entrez Gene 10144
HGNC 19367
MIM 613299
UniProt O94988  
 FAM13A identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for FAM13A
Molecular Function
    GTPase activator activity GO:0005096 TAS
Biological Process
    signal transduction GO:0007165 IEA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified FAM13A in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FAM13A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 MPP1 4354
Affinity Capture-MS Homo sapiens
3 RAC1 5879
FRET Homo sapiens
4 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
5 PPP2R5E 5529
Affinity Capture-MS Homo sapiens
6 TBCCD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 AHCYL1 10768
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 YWHAB 7529
Affinity Capture-MS Homo sapiens
9 YWHAE 7531
Affinity Capture-MS Homo sapiens
10 PCNA 5111
Affinity Capture-MS Homo sapiens
11 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ERP44 23071
Affinity Capture-MS Homo sapiens
13 AHCYL2 23382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MYO6 4646
Affinity Capture-MS Homo sapiens
15 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PPP2R5C 5527
Affinity Capture-MS Homo sapiens
17 PPP2CA 5515
Affinity Capture-MS Homo sapiens
18 YES1 7525
Affinity Capture-MS Homo sapiens
19 PPP2R3B  
Affinity Capture-MS Homo sapiens
20 UNC119 9094
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PPP2R5A 5525
Affinity Capture-MS Homo sapiens
23 RTEL1 51750
Affinity Capture-MS Homo sapiens
24 UNC119B 84747
Affinity Capture-MS Homo sapiens
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