Gene description for Ppp2r1a
Gene name protein phosphatase 2, regulatory subunit A, alpha
Gene symbol Ppp2r1a
Other names/aliases 6330556D22Rik
PP2A
PR65
Species Mus musculus
 Database cross references - Ppp2r1a
ExoCarta ExoCarta_51792
Vesiclepedia VP_51792
Entrez Gene 51792
UniProt Q76MZ3  
 Ppp2r1a identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
Mast cells 17486113    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppp2r1a
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IDA
    protein binding GO:0005515 IPI
    protein phosphatase regulator activity GO:0019888 IBA
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 ISO
    protein antigen binding GO:1990405 IEA
    protein antigen binding GO:1990405 ISO
Biological Process
    chromosome segregation GO:0007059 ISO
    chromosome segregation GO:0007059 ISS
    female meiotic nuclear division GO:0007143 IMP
    negative regulation of hippo signaling GO:0035331 ISO
    negative regulation of hippo signaling GO:0035331 ISS
    T cell homeostasis GO:0043029 IMP
    spindle assembly GO:0051225 IBA
    meiotic spindle elongation GO:0051232 IMP
    mitotic sister chromatid separation GO:0051306 IMP
    meiotic sister chromatid cohesion, centromeric GO:0051754 IBA
    meiotic sister chromatid cohesion, centromeric GO:0051754 IMP
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IMP
    peptidyl-serine dephosphorylation GO:0070262 IDA
    regulation of meiotic cell cycle process involved in oocyte maturation GO:1903538 IMP
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IMP
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IBA
    protein phosphatase type 2A complex GO:0000159 IDA
    protein phosphatase type 2A complex GO:0000159 ISO
    chromosome, centromeric region GO:0000775 ISO
    chromosome, centromeric region GO:0000775 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    lateral plasma membrane GO:0016328 IEA
    lateral plasma membrane GO:0016328 ISO
    dendrite GO:0030425 IEA
    neuron projection GO:0043005 ISO
    neuronal cell body GO:0043025 IEA
    neuronal cell body GO:0043025 ISO
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
    FAR/SIN/STRIPAK complex GO:0090443 ISO
    FAR/SIN/STRIPAK complex GO:0090443 ISS
    glutamatergic synapse GO:0098978 EXP
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified Ppp2r1a in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
7
Experiment ID 188
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|UCHL1|HSP90
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppp2r1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INTS4  
Affinity Capture-MS Homo sapiens
2 HPS5 11234
Affinity Capture-MS Homo sapiens
3 MON2 23041
Affinity Capture-MS Homo sapiens
4 ARHGEF2 9181
Affinity Capture-MS Homo sapiens
5 DPP9 91039
Affinity Capture-MS Homo sapiens
6 MED17  
Affinity Capture-MS Homo sapiens
7 CCDC174  
Affinity Capture-MS Homo sapiens
8 TBCCD1  
Affinity Capture-MS Homo sapiens
9 KIAA2013 90231
Affinity Capture-MS Homo sapiens
10 CEP170 9859
Affinity Capture-MS Homo sapiens
11 Fmr1  
Affinity Capture-MS Mus musculus
12 GAK 2580
Affinity Capture-MS Homo sapiens
13 Cebpa  
Affinity Capture-MS Mus musculus
14 STRN3 29966
Affinity Capture-MS Homo sapiens
15 KIF20A 10112
Affinity Capture-MS Homo sapiens
16 INTS1 26173
Affinity Capture-MS Homo sapiens
17 Ywhaz 22631
Affinity Capture-MS Mus musculus
18 Adcy8  
Affinity Capture-Western Mus musculus
19 Inppl1  
Affinity Capture-Western Mus musculus
20 PCGF2 7703
Affinity Capture-MS Homo sapiens
21 INTS9 55756
Affinity Capture-MS Homo sapiens
22 SRCAP  
Affinity Capture-MS Homo sapiens
23 ANKLE2 23141
Affinity Capture-MS Homo sapiens
24 STRN 6801
Affinity Capture-MS Homo sapiens
25 Atm  
Biochemical Activity Mus musculus
26 PPFIA3 8541
Affinity Capture-MS Homo sapiens
27 COL5A1 1289
Affinity Capture-MS Homo sapiens
28 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SOGA1 140710
Affinity Capture-MS Homo sapiens
30 PPP2R5C 5527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GKAP1  
Affinity Capture-MS Homo sapiens
32 CUX1 1523
Affinity Capture-MS Homo sapiens
33 INTS12  
Affinity Capture-MS Homo sapiens
34 STX18 53407
Affinity Capture-MS Homo sapiens
35 Mapt  
Affinity Capture-MS Mus musculus
36 CCDC6 8030
Affinity Capture-MS Homo sapiens
37 Ppp2cb 19053
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
38 INTS6 26512
Affinity Capture-MS Homo sapiens
39 Eed  
Affinity Capture-MS Mus musculus
40 Tnik  
Affinity Capture-MS Mus musculus
41 DPM3 54344
Affinity Capture-MS Homo sapiens
42 Pde4dip  
Affinity Capture-MS Mus musculus
43 CTTNBP2NL  
Affinity Capture-MS Homo sapiens
44 CEP131 22994
Affinity Capture-MS Homo sapiens
45 Nr3c1  
Affinity Capture-Western Mus musculus
46 Zfand6 65098
Co-fractionation Mus musculus
47 METTL13 51603
Affinity Capture-MS Homo sapiens
48 FOXC1  
Affinity Capture-MS Homo sapiens
49 CPSF3L 54973
Affinity Capture-MS Homo sapiens
50 AVL9 23080
Affinity Capture-MS Homo sapiens
51 Atg16l1  
Affinity Capture-MS Mus musculus
52 MOB4 25843
Affinity Capture-MS Homo sapiens
53 FAM122A  
Affinity Capture-MS Homo sapiens
54 Ppp2ca 19052
Two-hybrid Mus musculus
55 ASNA1 439
Affinity Capture-MS Homo sapiens
56 FOPNL  
Affinity Capture-MS Homo sapiens
57 Ppp2ca 24672
Affinity Capture-Western Rattus norvegicus
58 DYNLL1 8655
Affinity Capture-MS Homo sapiens
59 Agap2  
Affinity Capture-MS Mus musculus
60 CTSC 1075
Affinity Capture-MS Homo sapiens
61 TYK2 7297
Affinity Capture-MS Homo sapiens
62 Nanog  
Affinity Capture-MS Mus musculus
63 INTS7  
Affinity Capture-MS Homo sapiens
64 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 Fancd2  
Affinity Capture-MS Mus musculus
66 Ppp2r3a  
Affinity Capture-Western Mus musculus
67 RAB11FIP5 26056
Affinity Capture-MS Homo sapiens
68 CEP72  
Affinity Capture-MS Homo sapiens
69 ACTR10 55860
Affinity Capture-MS Homo sapiens
70 KRT79 338785
Affinity Capture-MS Homo sapiens
71 FGFR1OP  
Affinity Capture-MS Homo sapiens
72 NAB1 4664
Affinity Capture-MS Homo sapiens
73 ELP3 55140
Affinity Capture-MS Homo sapiens
74 PPP4R1 9989
Affinity Capture-MS Homo sapiens
75 PPP2R3A  
Affinity Capture-MS Homo sapiens
76 Mycbp2 105689
Affinity Capture-MS Mus musculus
77 Strn3  
Co-fractionation Mus musculus
78 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
79 STRIP1 85369
Affinity Capture-MS Homo sapiens
80 Ptpra 19262
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
81 Axin1  
Affinity Capture-Western Mus musculus
82 ASCC1 51008
Affinity Capture-MS Homo sapiens
83 ZGRF1 55345
Affinity Capture-MS Homo sapiens
84 PRCP 5547
Affinity Capture-MS Homo sapiens
85 SF1 7536
Affinity Capture-MS Homo sapiens
86 SGOL1  
Affinity Capture-MS Homo sapiens
87 Fbxl16  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
88 MRPL19 9801
Affinity Capture-MS Homo sapiens
89 FAM13A 10144
Affinity Capture-MS Homo sapiens
90 ESCO1  
Affinity Capture-MS Homo sapiens
91 Unc5b 107449
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
92 SET 6418
Affinity Capture-MS Homo sapiens
93 MPZL1 9019
Affinity Capture-MS Homo sapiens
94 PKD2 5311
Affinity Capture-MS Homo sapiens
95 PCM1 5108
Affinity Capture-MS Homo sapiens
96 PPP2R5A 5525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 CEP350 9857
Affinity Capture-MS Homo sapiens
98 PPFIA1 8500
Affinity Capture-MS Homo sapiens
99 INTS5 80789
Affinity Capture-MS Homo sapiens
100 PPP2CB 5516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 PPME1 51400
Affinity Capture-MS Homo sapiens
102 GLUD1 2746
Affinity Capture-MS Homo sapiens
103 PPP2R5E 5529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 Ppfia3  
Co-fractionation Mus musculus
105 Pou5f1  
Affinity Capture-MS Mus musculus
106 CCHCR1  
Affinity Capture-MS Homo sapiens
107 STRN4 29888
Affinity Capture-MS Homo sapiens
108 FBXL16  
Affinity Capture-MS Homo sapiens
109 LGALS3 3958
Affinity Capture-MS Homo sapiens
110 Atxn1  
Affinity Capture-MS Mus musculus
111 Kctd13  
Affinity Capture-MS Mus musculus
112 CASP8 841
Affinity Capture-MS Homo sapiens
113 PRR14  
Affinity Capture-MS Homo sapiens
114 FMNL3 91010
Affinity Capture-MS Homo sapiens
115 NEK2  
Affinity Capture-MS Homo sapiens
116 PPP2R3C  
Affinity Capture-MS Homo sapiens
117 PAPSS1 9061
Affinity Capture-MS Homo sapiens
118 FECH 2235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 LIMD1 8994
Affinity Capture-MS Homo sapiens
120 C1QBP 708
Affinity Capture-MS Homo sapiens
121 PPP2R3B  
Affinity Capture-MS Homo sapiens
122 MTCL1 23255
Affinity Capture-MS Homo sapiens
123 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
124 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 Nr1i3  
Affinity Capture-Western Mus musculus
126 PRSS23 11098
Affinity Capture-MS Homo sapiens
127 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Ppp2r1a is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal IEA Reactome
Amplification of signal from the kinetochores IEA Reactome
Anchoring of the basal body to the plasma membrane IEA Reactome
Antiviral mechanism by IFN-stimulated genes IEA Reactome
AURKA Activation by TPX2 IEA Reactome
Beta-catenin phosphorylation cascade IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Centrosome maturation IEA Reactome
Cilium Assembly IEA Reactome
Costimulation by the CD28 family IEA Reactome
CTLA4 inhibitory signaling IEA Reactome
Cyclin A/B1/B2 associated events during G2/M transition IEA Reactome
Cyclin D associated events in G1 IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
DARPP-32 events IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane IEA Reactome
E2F mediated regulation of DNA replication IEA Reactome
EML4 and NUDC in mitotic spindle formation IEA Reactome
ERK/MAPK targets IEA Reactome
ERKs are inactivated IEA Reactome
G alpha (i) signalling events IEA Reactome
G1 Phase IEA Reactome
G1/S Transition IEA Reactome
G2/M Transition IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
GPCR downstream signalling IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Inhibition of replication initiation of damaged DNA by RB1/E2F1 IEA Reactome
Initiation of Nuclear Envelope (NE) Reformation IEA Reactome
Innate Immune System IEA Reactome
Interferon Signaling IEA Reactome
Interleukin-17 signaling IEA Reactome
Intracellular signaling by second messengers IEA Reactome
Loss of Nlp from mitotic centrosomes IEA Reactome
Loss of proteins required for interphase microtubule organization from the centrosome IEA Reactome
M Phase IEA Reactome
MAP kinase activation IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK targets/ Nuclear events mediated by MAP kinases IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
Metabolism of RNA IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic G1 phase and G1/S transition IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Spindle Checkpoint IEA Reactome
MyD88 cascade initiated on plasma membrane IEA Reactome
MyD88 dependent cascade initiated on endosome IEA Reactome
MyD88-independent TLR4 cascade IEA Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane IEA Reactome
Negative regulation of FGFR1 signaling IEA Reactome
Negative regulation of FGFR2 signaling IEA Reactome
Negative regulation of FGFR3 signaling IEA Reactome
Negative regulation of FGFR4 signaling IEA Reactome
Negative regulation of MAPK pathway IEA Reactome
Negative regulation of the PI3K/AKT network IEA Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) IEA Reactome
Nonsense-Mediated Decay (NMD) IEA Reactome
Nuclear Envelope (NE) Reassembly IEA Reactome
Nuclear Events (kinase and transcription factor activation) IEA Reactome
Opioid Signalling IEA Reactome
Organelle biogenesis and maintenance IEA Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IEA Reactome
PIP3 activates AKT signaling IEA Reactome
PKR-mediated signaling IEA Reactome
Platelet homeostasis IEA Reactome
Platelet sensitization by LDL IEA Reactome
RAF activation IEA Reactome
RAF/MAP kinase cascade IEA Reactome
Recruitment of mitotic centrosome proteins and complexes IEA Reactome
Recruitment of NuMA to mitotic centrosomes IEA Reactome
Regulation of PLK1 Activity at G2/M Transition IEA Reactome
Regulation of TP53 Activity IEA Reactome
Regulation of TP53 Degradation IEA Reactome
Regulation of TP53 Expression and Degradation IEA Reactome
Resolution of Sister Chromatid Cohesion IEA Reactome
Response of endothelial cells to shear stress IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by FGFR IEA Reactome
Signaling by FGFR1 IEA Reactome
Signaling by FGFR2 IEA Reactome
Signaling by FGFR3 IEA Reactome
Signaling by FGFR4 IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by WNT IEA Reactome
Spry regulation of FGF signaling IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade IEA Reactome
Toll Like Receptor 2 (TLR2) Cascade IEA Reactome
Toll Like Receptor 3 (TLR3) Cascade IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome
Toll Like Receptor 5 (TLR5) Cascade IEA Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade IEA Reactome
Toll Like Receptor 9 (TLR9) Cascade IEA Reactome
Toll Like Receptor TLR1:TLR2 Cascade IEA Reactome
Toll Like Receptor TLR6:TLR2 Cascade IEA Reactome
Toll-like Receptor Cascades IEA Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling IEA Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells IEA Reactome





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