Gene description for TYK2
Gene name tyrosine kinase 2
Gene symbol TYK2
Other names/aliases IMD35
JTK1
Species Homo sapiens
 Database cross references - TYK2
ExoCarta ExoCarta_7297
Vesiclepedia VP_7297
Entrez Gene 7297
HGNC 12440
MIM 176941
UniProt P29597  
 TYK2 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TYK2
Molecular Function
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IC
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS
    growth hormone receptor binding GO:0005131 IBA
    growth hormone receptor binding GO:0005131 IPI
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    type 1 angiotensin receptor binding GO:0031702 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 TAS
    immune response GO:0006955 NAS
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 TAS
    cytokine-mediated signaling pathway GO:0019221 IBA
    cytokine-mediated signaling pathway GO:0019221 TAS
    cell differentiation GO:0030154 IBA
    positive regulation of type II interferon production GO:0032729 IDA
    positive regulation of interleukin-17 production GO:0032740 NAS
    positive regulation of natural killer cell proliferation GO:0032819 IDA
    intracellular signal transduction GO:0035556 IBA
    interleukin-12-mediated signaling pathway GO:0035722 IDA
    interleukin-23-mediated signaling pathway GO:0038155 IDA
    type III interferon-mediated signaling pathway GO:0038196 NAS
    positive regulation of T cell proliferation GO:0042102 IDA
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IDA
    positive regulation of NK T cell proliferation GO:0051142 IDA
    positive regulation of NK T cell proliferation GO:0051142 NAS
    type II interferon-mediated signaling pathway GO:0060333 IDA
    type I interferon-mediated signaling pathway GO:0060337 IDA
    type I interferon-mediated signaling pathway GO:0060337 NAS
    type I interferon-mediated signaling pathway GO:0060337 TAS
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IBA
    cellular response to virus GO:0098586 NAS
    interleukin-10-mediated signaling pathway GO:0140105 IDA
    positive regulation of protein localization to nucleus GO:1900182 IDA
    positive regulation of T-helper 17 type immune response GO:2000318 NAS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    cytoplasmic side of plasma membrane GO:0009898 IC
    extrinsic component of plasma membrane GO:0019897 TAS
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IC
    interleukin-12 receptor complex GO:0042022 NAS
    extracellular exosome GO:0070062 HDA
    interleukin-23 receptor complex GO:0072536 NAS
 Experiment description of studies that identified TYK2 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TYK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
2 OXCT1 5019
Co-fractionation Homo sapiens
3 KHDRBS3  
Two-hybrid Homo sapiens
4 GMNN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CCT3 7203
Affinity Capture-MS Homo sapiens
6 IDH1 3417
Co-fractionation Homo sapiens
7 TK1 7083
Two-hybrid Homo sapiens
8 SIAH2 6478
Affinity Capture-Western Homo sapiens
9 TRAF4 9618
Two-hybrid Homo sapiens
10 LPAR6  
Affinity Capture-MS Homo sapiens
11 CDH8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TRIM66  
Affinity Capture-MS Homo sapiens
13 C19orf38  
Affinity Capture-MS Homo sapiens
14 SIVA1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
15 SLC2A1 6513
Affinity Capture-MS Homo sapiens
16 SOCS1  
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
17 CCT4 10575
Affinity Capture-MS Homo sapiens
18 ECI1 1632
Co-fractionation Homo sapiens
19 CD79A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PTPN1 5770
Affinity Capture-Western Homo sapiens
21 TAF1  
Affinity Capture-MS Homo sapiens
22 FAXC  
Affinity Capture-MS Homo sapiens
23 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
24 IL6ST 3572
Affinity Capture-Western Homo sapiens
25 RUVBL1 8607
Affinity Capture-MS Homo sapiens
26 TRIM28 10155
Affinity Capture-MS Homo sapiens
27 WDR20 91833
Affinity Capture-MS Homo sapiens
28 TMEM130  
Affinity Capture-MS Homo sapiens
29 PLAUR 5329
Affinity Capture-Western Homo sapiens
30 Trp53bp1  
Affinity Capture-MS Mus musculus
31 COPS5 10987
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
32 KRT40  
Two-hybrid Homo sapiens
33 TNFRSF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 PMEL 6490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 TACSTD2 4070
Affinity Capture-MS Homo sapiens
36 DGCR2 9993
Affinity Capture-MS Homo sapiens
37 TNFRSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 IL17RA 23765
Affinity Capture-MS Homo sapiens
39 OAT 4942
Co-fractionation Homo sapiens
40 MAS1  
Affinity Capture-MS Homo sapiens
41 GPR156  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CCT2 10576
Affinity Capture-MS Homo sapiens
43 GOLGA6L9  
Two-hybrid Homo sapiens
44 RAN 5901
Affinity Capture-MS Homo sapiens
45 STAM2 10254
Affinity Capture-Western Homo sapiens
46 DLD 1738
Co-fractionation Homo sapiens
47 TCP1 6950
Affinity Capture-MS Homo sapiens
48 VAV1 7409
Affinity Capture-Western Homo sapiens
49 FHL3 2275
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 CLSTN1 22883
Affinity Capture-MS Homo sapiens
51 LYN 4067
Reconstituted Complex Homo sapiens
52 CCT5 22948
Affinity Capture-MS Homo sapiens
53 CBL 867
Affinity Capture-Western Homo sapiens
54 MPL 4352
Affinity Capture-MS Homo sapiens
55 FYN 2534
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
56 TYK2 7297
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 DDX5 1655
Affinity Capture-MS Homo sapiens
58 KRTAP6-3  
Two-hybrid Homo sapiens
59 ZNF333  
Affinity Capture-MS Homo sapiens
60 CLSTN2 64084
Affinity Capture-MS Homo sapiens
61 KLF10  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
62 SPDYE4  
Affinity Capture-MS Homo sapiens
63 RNF13 11342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 DNM2 1785
Two-hybrid Homo sapiens
65 LRRC46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 Dlgap4  
Affinity Capture-MS Mus musculus
67 TMCO3 55002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 LRP8 7804
Affinity Capture-MS Homo sapiens
69 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
70 CYSRT1 375791
Two-hybrid Homo sapiens
71 CRKL 1399
Affinity Capture-Western Homo sapiens
72 CXCR4 7852
Affinity Capture-MS Homo sapiens
73 PTPN6 5777
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
74 BAG2 9532
Affinity Capture-MS Homo sapiens
75 CCT6A 908
Affinity Capture-MS Homo sapiens
76 UBE2L6 9246
Affinity Capture-Western Homo sapiens
77 IFT43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 CD6 923
Affinity Capture-MS Homo sapiens
79 MADD 8567
Affinity Capture-MS Homo sapiens
80 RIPK4  
Affinity Capture-MS Homo sapiens
81 ELP2 55250
Affinity Capture-Western Homo sapiens
82 NXF1 10482
Affinity Capture-RNA Homo sapiens
83 TUBA4A 7277
Affinity Capture-MS Homo sapiens
84 PRMT5 10419
Reconstituted Complex Homo sapiens
85 OPTC  
Affinity Capture-MS Homo sapiens
86 STAT1 6772
Biochemical Activity Homo sapiens
87 IFNAR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
88 JAK1 3716
Affinity Capture-Western Homo sapiens
89 CEP170B  
Affinity Capture-MS Homo sapiens
90 AADAT  
Co-fractionation Homo sapiens
91 MIER2  
Affinity Capture-MS Homo sapiens
92 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 TRAK1 22906
Affinity Capture-MS Homo sapiens
94 XRCC5 7520
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
95 PTAFR  
Affinity Capture-Western Homo sapiens
96 GSR 2936
Co-fractionation Homo sapiens
97 CS 1431
Co-fractionation Homo sapiens
98 TP53BP2  
Two-hybrid Homo sapiens
99 CCT8 10694
Affinity Capture-MS Homo sapiens
100 TGFBR2 7048
Affinity Capture-MS Homo sapiens
101 LDLRAD1  
Affinity Capture-MS Homo sapiens
102 RUVBL2 10856
Affinity Capture-MS Homo sapiens
103 TXNRD2 10587
Co-fractionation Homo sapiens
104 ECHS1 1892
Co-fractionation Homo sapiens
105 NLGN3  
Affinity Capture-MS Homo sapiens
106 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 IRS2 8660
Reconstituted Complex Homo sapiens
108 HSPB1 3315
Affinity Capture-MS Homo sapiens
109 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
110 SHMT2 6472
Affinity Capture-RNA Homo sapiens
111 HNRNPK 3190
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
112 CCT7 10574
Affinity Capture-MS Homo sapiens
113 TF 7018
Co-fractionation Homo sapiens
114 TRAP1 10131
Co-fractionation Homo sapiens
115 PRDM5  
Two-hybrid Homo sapiens
116 IL4R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 KHDRBS2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
118 MOV10 4343
Affinity Capture-RNA Homo sapiens
119 ALYREF 10189
Affinity Capture-MS Homo sapiens
120 IL13RA1  
Affinity Capture-Western Homo sapiens
121 LRRC61 65999
Affinity Capture-MS Homo sapiens
122 GOT1 2805
Co-fractionation Homo sapiens
123 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
124 BRD1 23774
Affinity Capture-MS Homo sapiens
125 PIH1D1  
Affinity Capture-MS Homo sapiens
126 GHR  
Affinity Capture-Western Homo sapiens
127 GNB2L1 10399
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
128 C16orf71  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 PTCH1  
Affinity Capture-MS Homo sapiens
130 LNX1  
Affinity Capture-Western Homo sapiens
131 PROSER2 254427
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TYK2 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Evasion by RSV of host interferon responses TAS Reactome
IL-6-type cytokine receptor ligand interactions TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling IEA Reactome
Inactivation of CSF3 (G-CSF) signaling TAS Reactome
Infectious disease TAS Reactome
Interferon alpha/beta signaling TAS Reactome
Interferon alpha/beta signaling IEA Reactome
Interferon Signaling TAS Reactome
Interferon Signaling IEA Reactome
Interleukin-10 signaling TAS Reactome
Interleukin-12 family signaling IEA Reactome
Interleukin-12 family signaling TAS Reactome
Interleukin-12 signaling IEA Reactome
Interleukin-12 signaling TAS Reactome
Interleukin-20 family signaling TAS Reactome
Interleukin-23 signaling IEA Reactome
Interleukin-23 signaling TAS Reactome
Interleukin-27 signaling IEA Reactome
Interleukin-27 signaling TAS Reactome
Interleukin-35 Signalling TAS Reactome
Interleukin-4 and Interleukin-13 signaling TAS Reactome
Interleukin-6 family signaling TAS Reactome
Interleukin-6 family signaling IEA Reactome
Interleukin-6 signaling TAS Reactome
Interleukin-6 signaling IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK1 (ERK2) activation TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MAPK3 (ERK1) activation TAS Reactome
Other interleukin signaling TAS Reactome
Potential therapeutics for SARS TAS Reactome
RAF-independent MAPK1/3 activation TAS Reactome
Regulation of IFNA/IFNB signaling TAS Reactome
Regulation of IFNA/IFNB signaling IEA Reactome
Respiratory Syncytial Virus Infection Pathway TAS Reactome
RSV-host interactions TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Interleukins IEA Reactome
Viral Infection Pathways TAS Reactome





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