Gene description for MADD
Gene name	MAP-kinase activating death domain
Gene symbol	MADD
Other names/aliases	DENN IG20 RAB3GEP
Species	Homo sapiens
Database cross references - MADD
ExoCarta	ExoCarta_8567
Vesiclepedia	VP_8567
Entrez Gene	8567
HGNC	6766
MIM	603584
UniProt	Q8WXG6
MADD identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for MADD

Molecular Function     guanyl-nucleotide exchange factor activity GO:0005085 IBA     guanyl-nucleotide exchange factor activity GO:0005085 IDA     guanyl-nucleotide exchange factor activity GO:0005085 IMP     guanyl-nucleotide exchange factor activity GO:0005085 TAS     death receptor binding GO:0005123 TAS     protein binding GO:0005515 IPI     protein kinase activator activity GO:0030295 TAS Biological Process     cell surface receptor signaling pathway GO:0007166 TAS     regulation of Rab protein signal transduction GO:0032483 IBA     regulation of Rab protein signal transduction GO:0032483 IDA     regulation of apoptotic process GO:0042981 IBA     regulation of apoptotic process GO:0042981 IMP     positive regulation of MAPK cascade GO:0043410 IMP     regulation of cell cycle GO:0051726 IMP     execution phase of apoptosis GO:0097194 IMP     regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 IMP     regulation of extrinsic apoptotic signaling pathway GO:2001236 IDA Subcellular Localization     cytoplasm GO:0005737 TAS     cytosol GO:0005829 IBA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     membrane GO:0016020 IDA     axon GO:0030424 IEA