Gene description for TNFRSF1A
Gene name tumor necrosis factor receptor superfamily, member 1A
Gene symbol TNFRSF1A
Other names/aliases CD120a
FPF
MS5
TBP1
TNF-R
TNF-R-I
TNF-R55
TNFAR
TNFR1
TNFR1-d2
TNFR55
TNFR60
p55
p55-R
p60
Species Homo sapiens
 Database cross references - TNFRSF1A
ExoCarta ExoCarta_7132
Vesiclepedia VP_7132
Entrez Gene 7132
HGNC 11916
MIM 191190
UniProt P19438  
 TNFRSF1A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TNFRSF1A
Molecular Function
    tumor necrosis factor-activated receptor activity GO:0005031 TAS
    protein binding GO:0005515 IPI
    protein complex binding GO:0032403 IEA
    tumor necrosis factor binding GO:0043120 IEA
    protease binding GO:0002020 IEA
Biological Process
    viral process GO:0016032 IEA
    cellular response to mechanical stimulus GO:0071260 IEP
    tumor necrosis factor-mediated signaling pathway GO:0033209 TAS
    cellular response to estradiol stimulus GO:0071392 IEA
    cell surface receptor signaling pathway GO:0007166 TAS
    prostaglandin metabolic process GO:0006693 IEA
    response to ethanol GO:0045471 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA
    defense response to bacterium GO:0042742 IEA
    positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 IMP
    positive regulation of protein import into nucleus, translocation GO:0033160 IEA
    negative regulation of gene expression GO:0010629 IEA
    positive regulation of angiogenesis GO:0045766 IEA
    response to lipopolysaccharide GO:0032496 IEA
    response to wounding GO:0009611 IEA
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 TAS
    response to hypoxia GO:0001666 IEA
    protein heterooligomerization GO:0051291 IEA
    inflammatory response GO:0006954 ISS
    response to amino acid GO:0043200 IEA
    response to alkaloid GO:0043279 IEA
    tetrapyrrole metabolic process GO:0033013 IEA
    death-inducing signaling complex assembly GO:0071550 TAS
    negative regulation of inflammatory response GO:0050728 IMP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    negative regulation of apoptotic process GO:0043066 IEA
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    cytokine-mediated signaling pathway GO:0019221 ISS
    negative regulation of interleukin-6 production GO:0032715 IEA
    positive regulation of neuron apoptotic process GO:0043525 IEA
    positive regulation of inflammatory response GO:0050729 ISS
Subcellular Localization
    cell surface GO:0009986 IEA
    nucleus GO:0005634 IEA
    receptor complex GO:0043235 IDA
    membrane raft GO:0045121 IDA
    synapse GO:0045202 IEA
    extracellular region GO:0005576 NAS
    plasma membrane GO:0005886 TAS
    cytosol GO:0005829 IEA
    mitochondrion GO:0005739 IEA
    axon GO:0030424 IEA
    integral component of plasma membrane GO:0005887 TAS
    Golgi membrane GO:0000139 IDA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified TNFRSF1A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TNFRSF1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNF  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 CASP8 841
Co-purification Homo sapiens
3 PTPN11 5781
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
4 TRAF2 7186
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
5 GRB2 2885
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
6 CASP7  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
7 TRAP1 10131
Reconstituted Complex Homo sapiens
8 HSPA8 3312
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
9 FAS 355
Co-purification Homo sapiens
10 DAPK1 1612
Affinity Capture-Western Homo sapiens
11 PTPN6 5777
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
12 EZR 7430
Co-purification Homo sapiens
13 IKBKG 8517
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
14 FASLG 356
Co-purification Homo sapiens
15 TNFRSF1A 7132
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
16 MAPK8 5599
Co-purification Homo sapiens
17 MADD 8567
Invitro Homo sapiens
18 TRADD 8717
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 BID  
Co-purification Homo sapiens
20 RPS27A 6233
Affinity Capture-Western Homo sapiens
21 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
22 RIPK1 8737
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
23 TNFRSF10B 8795
Co-purification Homo sapiens
24 IKBKB 3551
Affinity Capture-Western Homo sapiens
25 FADD 8772
Co-purification Homo sapiens
26 ARHGDIA 396
Co-purification Homo sapiens
27 RIPK3 11035
Invivo Homo sapiens
28 TNFSF13 8741
Invitro Homo sapiens
29 UBE2I 7329
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
30 BAG4  
Affinity Capture-Western Homo sapiens
31 STAT1 6772
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
32 PSMD2 5708
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 JAK1 3716
Invitro Homo sapiens
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
34 BCL10  
Two-hybrid Homo sapiens
35 RIPK2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
36 CASP10  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
37 TNFSF12-TNFSF13  
Invitro Homo sapiens
38 GNB2L1 10399
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
39 LTB  
Invitro Homo sapiens
40 MSN 4478
Co-purification Homo sapiens
41 RHOA 387
Co-purification Homo sapiens
42 LTA  
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
43 NSMAF  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
44 DAP  
Affinity Capture-MS Homo sapiens
45 PIP4K2B 8396
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
46 JAK2 3717
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
47 FANCD2  
Affinity Capture-MS Homo sapiens
48 TRPC4AP  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
49 SUMO1 7341
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
50 TRAF1 7185
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which TNFRSF1A is involved
PathwayEvidenceSource
TNF signaling TAS Reactome
TNFR1-mediated proapoptotic signaling TAS Reactome





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