Gene description for JAK2
Gene name	Janus kinase 2
Gene symbol	JAK2
Other names/aliases	JTK10 THCYT3
Species	Homo sapiens
Database cross references - JAK2
ExoCarta	ExoCarta_3717
Entrez Gene	3717
HGNC	6192
MIM	147796
UniProt	O60674
JAK2 identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for JAK2

Molecular Function     heme binding GO:0020037 IDA     interleukin-12 receptor binding GO:0005143 ISS     type 1 angiotensin receptor binding GO:0031702 IEA     receptor binding GO:0005102 IPI     protein tyrosine kinase activity GO:0004713 TAS     histone kinase activity (H3-Y41 specific) GO:0035401 IDA     histone binding GO:0042393 IDA     ATP binding GO:0005524 IEA     insulin receptor substrate binding GO:0043560 IEA     growth hormone receptor binding GO:0005131 ISS     protein kinase binding GO:0019901 IDA     SH2 domain binding GO:0042169 IPI     acetylcholine receptor binding GO:0033130 IEA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     protein C-terminus binding GO:0008022 IEA     protein kinase activity GO:0004672 NAS     peptide hormone receptor binding GO:0051428 IEA     phosphatidylinositol 3-kinase binding GO:0043548 IEA     protein binding GO:0005515 IPI Biological Process     positive regulation of cell proliferation GO:0008284 IEA     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IEA     host programmed cell death induced by symbiont GO:0034050 IEA     activation of JAK2 kinase activity GO:0042977 ISS     regulation of inflammatory response GO:0050727 IDA     response to interleukin-12 GO:0070671 IDA     movement of cell or subcellular component GO:0006928 TAS     positive regulation of cell migration GO:0030335 IEA     positive regulation of cell differentiation GO:0045597 IEA     positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 ISS     tyrosine phosphorylation of Stat5 protein GO:0042506 IEA     positive regulation of cytosolic calcium ion concentration GO:0007204 IEA     regulation of apoptotic process GO:0042981 IBA     positive regulation of inflammatory response GO:0050729 IEA     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISS     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IEA     positive regulation of tumor necrosis factor production GO:0032760 ISS     axon regeneration GO:0031103 IEA     tyrosine phosphorylation of Stat1 protein GO:0042508 IEA     regulation of cell proliferation GO:0042127 IBA     tumor necrosis factor-mediated signaling pathway GO:0033209 IDA     signal transduction GO:0007165 ISS     mesoderm development GO:0007498 TAS     activation of MAPKK activity GO:0000186 IEA     response to tumor necrosis factor GO:0034612 IDA     apoptotic process GO:0006915 ISS     tyrosine phosphorylation of Stat3 protein GO:0042503 IEA     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     cytokine-mediated signaling pathway GO:0019221 TAS     protein autophosphorylation GO:0046777 ISS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     cell differentiation GO:0030154 ISS     positive regulation of insulin secretion GO:0032024 IEA     negative regulation of cell-cell adhesion GO:0022408 IEA     intracellular signal transduction GO:0035556 ISS     positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 ISS     negative regulation of cell proliferation GO:0008285 ISS     JAK-STAT cascade GO:0007259 TAS     negative regulation of neuron apoptotic process GO:0043524 IEA     platelet-derived growth factor receptor signaling pathway GO:0048008 IEA     growth hormone receptor signaling pathway GO:0060396 IDA     G-protein coupled receptor signaling pathway GO:0007186 IEA     negative regulation of heart contraction GO:0045822 IEA     positive regulation of phosphoprotein phosphatase activity GO:0032516 IEA     response to antibiotic GO:0046677 IDA     negative regulation of DNA binding GO:0043392 ISS     protein phosphorylation GO:0006468 TAS     hormone-mediated signaling pathway GO:0009755 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISS     mineralocorticoid receptor signaling pathway GO:0031959 IEA     histone H3-Y41 phosphorylation GO:0035409 IDA     peptidyl-tyrosine phosphorylation GO:0018108 ISS     extrinsic apoptotic signaling pathway GO:0097191 ISS     positive regulation of DNA binding GO:0043388 IEA     positive regulation of protein import into nucleus, translocation GO:0033160 IEA     cell migration GO:0016477 IBA     mammary gland epithelium development GO:0061180 ISS     blood coagulation GO:0007596 TAS     interferon-gamma-mediated signaling pathway GO:0060333 TAS     positive regulation of interleukin-1 beta production GO:0032731 IEA     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     innate immune response GO:0045087 IBA     positive regulation of cell-substrate adhesion GO:0010811 IDA     positive regulation of cell activation GO:0050867 IEA     interleukin-12-mediated signaling pathway GO:0035722 IDA     enzyme linked receptor protein signaling pathway GO:0007167 ISS     erythrocyte differentiation GO:0030218 ISS     chromatin organization GO:0006325 TAS     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 ISS     response to lipopolysaccharide GO:0032496 ISS     tyrosine phosphorylation of STAT protein GO:0007260 ISS     positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 ISS     response to hydroperoxide GO:0033194 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS     STAT protein import into nucleus GO:0007262 ISS     positive regulation of growth hormone receptor signaling pathway GO:0060399 ISS     regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     actin filament polymerization GO:0030041 NAS Subcellular Localization     nucleoplasm GO:0005654 TAS     endosome lumen GO:0031904 TAS     nucleus GO:0005634 IDA     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     nuclear matrix GO:0016363 IEA     cytoskeleton GO:0005856 IEA     cytosol GO:0005829 TAS     caveola GO:0005901 ISS     membrane raft GO:0045121 ISS     cytoplasm GO:0005737 IDA