Gene description for PTPN12
Gene name protein tyrosine phosphatase, non-receptor type 12
Gene symbol PTPN12
Other names/aliases PTP-PEST
Species Homo sapiens
 Database cross references - PTPN12
ExoCarta ExoCarta_5782
Entrez Gene 5782
HGNC 9645
MIM 600079
UniProt Q05209  
 PTPN12 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PTPN12
Molecular Function
    SH3 domain binding GO:0017124 IPI
    protein binding GO:0005515 IPI
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 TAS
Biological Process
    protein dephosphorylation GO:0006470 TAS
    peptidyl-tyrosine dephosphorylation GO:0035335 TAS
Subcellular Localization
    podosome GO:0002102 IEA
    plasma membrane GO:0005886 IDA
    cell projection GO:0042995 IEA
    cell junction GO:0030054 IEA
    cytosol GO:0005829 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PTPN12 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PTPN12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSN 2934
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PTPN12 is involved
No pathways found

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