Gene description for SMAD5
Gene name	SMAD family member 5
Gene symbol	SMAD5
Other names/aliases	DWFC JV5-1 MADH5
Species	Homo sapiens
Database cross references - SMAD5
ExoCarta	ExoCarta_4090
Entrez Gene	4090
HGNC	6771
MIM	603110
UniProt	Q99717
SMAD5 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for SMAD5

Molecular Function     ubiquitin protein ligase binding GO:0031625 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 IEA     protein binding GO:0005515 IPI     metal ion binding GO:0046872 IEA     receptor signaling protein activity GO:0005057 NAS     RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA     transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 TAS Biological Process     bone development GO:0060348 IEA     signal transduction GO:0007165 NAS     positive regulation of transcription, DNA-templated GO:0045893 NAS     cellular response to BMP stimulus GO:0071773 ISS     erythrocyte differentiation GO:0030218 IEA     protein phosphorylation GO:0006468 IEA     cellular response to organic cyclic compound GO:0071407 IEA     embryonic pattern specification GO:0009880 ISS     Mullerian duct regression GO:0001880 IEA     transforming growth factor beta receptor signaling pathway GO:0007179 NAS     ureteric bud development GO:0001657 IEA     positive regulation of osteoblast differentiation GO:0045669 IEA     positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 ISS     BMP signaling pathway GO:0030509 TAS     transcription, DNA-templated GO:0006351 IEA     germ cell development GO:0007281 IEA     cardiac muscle contraction GO:0060048 IEA     osteoblast fate commitment GO:0002051 IEA     intracellular signal transduction GO:0035556 TAS     cartilage development GO:0051216 IEA Subcellular Localization     transcription factor complex GO:0005667 IEA     nucleus GO:0005634 TAS     intracellular GO:0005622 NAS     cytoplasm GO:0005737 IDA     nucleoplasm GO:0005654 TAS     integral component of membrane GO:0016021 NAS     protein complex GO:0043234 IDA     cytosol GO:0005829 TAS